Inverted duplication pattern in anaphase bridges confirms the breakage-fusion-bridge (BFB) cycle model for 11q13 amplification

2007 ◽  
Vol 116 (1-2) ◽  
pp. 46-52 ◽  
Author(s):  
S.C. Reshmi ◽  
S. Roychoudhury ◽  
Z. Yu ◽  
E. Feingold ◽  
D. Potter ◽  
...  
Keyword(s):  
Cycle Model ◽  
Anaphase Bridges ◽  
Inverted Duplication ◽  
Bfb Cycle ◽  
11Q13 Amplification

scholarly journals Maize Chromosome Abnormalities and Breakage-Fusion-Bridge Cycles in Callus Cultures

2020 ◽  
Author(s):  
Margarida L.R. Aguiar-Perecin ◽  
Janay A. Santos-Serejo ◽  
José R. Gardingo ◽  
Mateus Mondin
Keyword(s):  
Dna Sequences ◽  
De Novo ◽  
Callus Cultures ◽  
Chromosome Abnormalities ◽  
Anaphase Bridges ◽  
C Banding ◽  
Chromosome Healing ◽  
Bfb Cycle ◽  
Chromosome Alterations

The maize karyotype was first characterized by the observation of pachytene chromosomes. The somatic chromosomes were identified by C-banding and FISH with repetitive DNA sequences. C-banding was useful for the identification of chromosome abnormalities in callus cultures. In the present review, we focus on the involvement of heterochromatic knobs on the occurrence of chromosome abnormalities in callus cultures. In a previous work we detected anaphase bridges resulting from delayed chromatid separation at knob regions and typical bridges derived from dicentric chromatids in cultures. The analysis of altered chromosomes showed they were derived from a chromatid-type breakage-fusion-bridge (BFB) cycle. Fluorescent in situ hybridization (FISH) showed signals of telomere sequences in the broken chromosome arm, thus giving evidence of de novo telomere formation on the broken chromosome end. Further observations of long- and short-term cultures have shown the presence of chromosome alterations derived from BFB cycles followed by chromosome healing. Additionally, the occurrence of unequal crossing over in a knob region was observed in callus culture. These results are of interest for studies on the mechanisms of chromosome alterations during evolution.

The reciprocity of the quality of care providers' occupational life of and the quality of care: A cycle model

2013 ◽  
Author(s):  
Marco Ferrara ◽  
Sara Viotti ◽  
Daniela Converso ◽  
Valentina Trotta ◽  
Gloria Guidetti ◽  
...  
Keyword(s):  
Quality Of Care ◽  
Care Providers ◽  
Cycle Model ◽  
Occupational Life

Clinical and molecular cytogenetic characterization of two cases of inverted duplication deletion 8p

2020 ◽  
pp. 41-42
Author(s):  
Д.А. Юрченко ◽  
М.Е. Миньженкова ◽  
Е.Л. Дадали ◽  
Н.В. Шилова
Keyword(s):  
Mental Retardation ◽  
Congenital Heart ◽  
Heart Defects ◽  
Clinical Manifestations ◽  
Formation Mechanisms ◽  
Agenesis Of Corpus Callosum ◽  
Molecular Cytogenetic ◽  
Inverted Duplication ◽  
Cytogenetic Characterization

Синдром инвертированной дупликации короткого плеча хромосомы 8 со смежной терминальной делециенй (inv dup del(8p), ORPHA 96092) - редкая хромосомная аномалия (ХА) с частотой 1/10000-1/30000 живорожденных. В статье представлены клинические и молекулярно-цитогенетические характеристики двух неродственных пациентов с синдромом inv dup del(8p) и уточнены механизмы формирования хромосомного дисбаланса. Inverted duplication deletion 8p syndrome (inv dup del(8p), ORPHA 96092) is a rare chromosomal abnormality with a frequency of 1:10,000 - 30,000 newborns. Clinical manifestations of this syndrome include mental retardation, facial anomalies, hypoplasia/agenesis of corpus callosum, scoliosis and/or kyphosis, hypotonia, congenital heart defects. The article presents the clinical and molecular cytogenetic characteristics of two patients with inv dup del (8p) syndrome and clarifies the formation mechanisms.

Sensitivity of a coupled climate-carbon cycle model to large volcanic eruptions during the last millennium

Tellus B ◽  
2010 ◽  
Vol 62 (5) ◽  
Author(s):  
Victor Brovkin ◽  
Stephan J. Lorenz ◽  
Johann Jungclaus ◽  
Thomas Raddatz ◽  
Claudia Timmreck ◽  
...  
Keyword(s):  
Carbon Cycle ◽  
Volcanic Eruptions ◽  
Last Millennium ◽  
Cycle Model ◽  
Carbon Cycle Model ◽  
Large Volcanic Eruptions

Designing and Implementing an Online Carbon Cycle Model Service Platform Based on OGC Web Processing Service

2012 ◽  
Vol 14 (3) ◽  
pp. 320-326
Author(s):  
Nan WU ◽  
Honglin HE ◽  
Li ZHANG ◽  
Xiaoli REN ◽  
Yuanchun ZHOU ◽  
...  
Keyword(s):  
Carbon Cycle ◽  
Cycle Model ◽  
Service Platform ◽  
Carbon Cycle Model ◽  
Processing Service
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