Treatment-Associated Suicidal Ideation and Adverse Effects in an Open, Multicenter Trial of Fluoxetine for Major Depressive Episodes

2006 ◽  
Vol 76 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Roy H. Perlis ◽  
Charles M. Beasley Jr. ◽  
James D. Wines Jr. ◽  
Roy N. Tamura ◽  
Cristina Cusin ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Adverse Effects ◽  
Multicenter Trial ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Six Elderly Suicides in a 1-Year Period in a Rural Midwestern Community

1995 ◽  
Vol 7 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Sanford I. Finkel ◽  
Marshall Rosman
Keyword(s):  
American Medical Association ◽  
Suicidal Ideation ◽  
Medical Association ◽  
American Medical ◽  
Continuing Education ◽  
Family Member ◽  
Major Depressive ◽  
Attending Physicians ◽  
Major Depressive Episodes ◽  
Depressive Episodes

In a 1-year period, 6 of 11 suicides in a rural Wisconsin county were committed by people over the age of 60. At the request of the local coroner, the American Medical Association sent a team of investigators to perform psychological autopsies. Family member survivors, friends, and attending physicians were interviewed. The majority of suicide victims had evidence of major depressive episodes, delusions that they had a terminal physical illness, and knowledge of family/friends who had committed suicide. Most had seen their physician within 48 hours before their death. Continuing education efforts focused on increasing a physician's abilities to recognize depression and suicidal ideation have ensued, based on this experience.

Associations Between Substance Use Disorders and Suicidal Ideation: An Investigation of Latino Emerging Adults

2018 ◽  
Vol 7 (1) ◽  
pp. 21-30
Author(s):  
Emily A. Limas ◽  
Ellen L. Vaughan
Keyword(s):  
Substance Use ◽  
Suicidal Ideation ◽  
Emerging Adults ◽  
Substance Use Disorders ◽  
Regression Analyses ◽  
Major Depressive ◽  
The Past ◽  
Religiosity And Depression ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Suicide is ranked as the second leading cause of death among emerging adults (aged 18–25 years). The purpose of this study was to test the associations between substance use disorders and suicidal ideation while controlling for religiosity and depression, among Latino emerging adults. Participants were 3,372 Latino, noninstitutionalized, U.S. residents aged 18- to 25-year-old who participated in the 2011 National Survey on Drug Use and Health. Binomial logistic regression analyses tested the relationships between major depressive episodes (MDEs), substance abuse/dependence, and past-year suicidal ideation. Results showed that substance use disorders and MDEs were both associated with increased odds of suicidal ideation in emerging adult Latinos within the past year. Clinical and research implications as well as study limitations are discussed.

Covariate Health Determinants of Suicidal Ideation, Suicide Plans, and Suicide Attempts among African American Males with and without Major Depressive Episodes

2021 ◽  
Author(s):  
Areen Omary
Keyword(s):  
African American ◽  
Suicidal Ideation ◽  
African American Males ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Suicide Attempts ◽  
African American Men ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Objectives. To examine if major depressive episodes can predict risk chances for suicidal ideation, suicide plans, and suicide attempts among African American males while adjusting for covariates of age, education, and income. Methods. Data from the 2018 National Survey on Drug Use and Health were extracted and analyzed. We found data for 2,301 adult African American men with and without major depressive episodes, representing a population size of 13,210,069.53 in the United States. Results. African American men with major depressive episodes were at higher risk for suicidal ideation and suicide planning than their counterparts without a major depressive episode. However, the two groups with and without major depressive episodes had equal risk chances for suicide attempts. Conclusions. A closer examination of suicide covariate variables among African American men with and without a major depressive episode furnishes critical distinctions between the two populations. This can facilitate more responsive, tailored suicide prevention strategies for the male African American population, especially among the at-risk male adults in this group with major depressive episodes.

What is the role of conventional antidepressants in the treatment of major depressive episodes with Mixed Features Specifier?

CNS Spectrums ◽  
2016 ◽  
Vol 22 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Gianni L. Faedda ◽  
Ciro Marangoni
Keyword(s):  
Clinical Trials ◽  
Unipolar Depression ◽  
Preliminary Evidence ◽  
Major Depressive ◽  
Pharmacological Management ◽  
Diagnostic And Statistical Manual ◽  
Mixed Features ◽  
Effective Use ◽  
Major Depressive Episodes ◽  
Depressive Episodes

The newly introduced Mixed Features Specifier of Major Depressive Episode and Disorder (MDE/MDD) is especially challenging in terms of pharmacological management. Prior to the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of the mixed features specifier were intradepressive hypomanic symptoms, always and only associated with bipolar disorder (BD).Intradepressive hypomanic symptoms, mostly referred to as depressive mixed states (DMX), have been poorly characterized, and their treatment offers significant challenges. To understand the diagnostic context of DMX, we trace the nosological changes and collocation of intradepressive hypomanic symptoms, and examine diagnostic and prognostic implications of such mixed features.One of the reasons so little is known about the treatment of DMX is that depressed patients with rapid cycling, substance abuse disorder, and suicidal ideation/attempts are routinely excluded from clinical trials of antidepressants. The exclusion of DMX patients from clinical trials has prevented an assessment of the safety and tolerability of short- and long-term use of antidepressants. Therefore, the generalization of data obtained in clinical trials for unipolar depression to patients with intradepressive hypomanic features is inappropriate and methodologically flawed.A selective review of the literature shows that antidepressants alone have limited efficacy in DMX, but they have the potential to induce, maintain, or worsen mixed features during depressive episodes in BD. On the other hand, preliminary evidence supports the effective use of some atypical antipsychotics in the treatment of DMX.

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