Carney Complex: Pathology and Molecular Genetics

2006 ◽  
Vol 83 (3-4) ◽  
pp. 189-199 ◽  
Author(s):  
Sosipatros A. Boikos ◽  
Constantine A. Stratakis
Keyword(s):  
Molecular Genetics ◽  
Carney Complex

Clinical and molecular genetics of Carney complex

2003 ◽  
Vol 78 (2) ◽  
pp. 83-92 ◽  
Author(s):  
Fabiano Sandrini ◽  
Constantine Stratakis
Keyword(s):  
Molecular Genetics ◽  
Carney Complex

scholarly journals Primary pigmented nodular adrenocortical disease and Cushing's syndrome

2007 ◽  
Vol 51 (8) ◽  
pp. 1238-1244 ◽  
Author(s):  
Anelia Horvath ◽  
Constantine Stratakis
Keyword(s):  
Molecular Genetics ◽  
Cushing’S Syndrome ◽  
Adrenal Glands ◽  
Skin Pigmentation ◽  
Carney Complex ◽  
Cushing's Syndrome ◽  
Camp Signaling ◽  
Camp Signaling Pathway ◽  
Molecular Studies ◽  
Adrenocortical Hyperplasia

Primary pigmented nodular adrenocortical disease (PPNAD) is a form of bilateral adrenocortical hyperplasia that is often associated with corticotrophin (ACTH)-independent Cushing's syndrome (CS) and is characterized by small to normal-sized adrenal glands containing multiple small cortical pigmented nodules (1,2). PPNAD may occur in an isolated form or associated with a multiple neoplasia syndrome, the complex of spotty skin pigmentation, myxomas, and endocrine overactivity, or Carney complex, in which Cushing's syndrome is the most common endocrine manifestation (3). Molecular studies have led to the identification of several genes, defects in which may predispose PPNAD formation; all of these molecules play important role for the cAMP signaling pathway. This review intends to present the most recent knowledge of the pathology and molecular genetics of the benign bilateral adrenocortical lesions, as well as to discuss the modern tools for diagnostics and treatment of this condition.

scholarly journals MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics

2015 ◽  
Vol 103 (1) ◽  
pp. 18-31 ◽  
Author(s):  
Marie Helene Schernthaner-Reiter ◽  
Giampaolo Trivellin ◽  
Constantine A. Stratakis
Keyword(s):  
Molecular Genetics ◽  
Carney Complex

Clinical and molecular genetics of Carney complex

2010 ◽  
Vol 24 (3) ◽  
pp. 389-399 ◽  
Author(s):  
Anya Rothenbuhler ◽  
Constantine A. Stratakis
Keyword(s):  
Molecular Genetics ◽  
Carney Complex

characterization of the adrenal gland pathology of carney complex, and molecular genetics of the disease.

1998 ◽  
Vol 24 (3-4) ◽  
pp. 863-864 ◽  
Author(s):  
Lawrence S. Kirschner ◽  
Susan E. Taymans ◽  
Constantine A. Stratakis
Keyword(s):  
Adrenal Gland ◽  
Molecular Genetics ◽  
Carney Complex

Introduction

1978 ◽  
Vol 36 (3) ◽  
pp. 543-544
Author(s):  
W. Bernard
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Nucleic Acid ◽  
Gene Mapping ◽  
Molecular Genetics ◽  
Cell Biology ◽  
Gene Activity ◽  
Close Connection ◽  
Basic Information ◽  
Simple Systems

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.

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