Renal Angiotensin Receptor Type 1 and 2 Upregulation in Intrauterine Growth Restriction of Newborn Piglets

2006 ◽  
Vol 182 (2) ◽  
pp. 106-114 ◽  
Author(s):  
Michael Rüster ◽  
Manfred Sommer ◽  
Günter Stein ◽  
Kathrin Bauer ◽  
Bernd Walter ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Receptor Type ◽  
Angiotensin Receptor ◽  
Intrauterine Growth ◽  
Newborn Piglets

Increased cerebral lactate during hypoxia may be neuroprotective in newborn piglets with intrauterine growth restriction

2007 ◽  
Vol 1179 ◽  
pp. 79-88 ◽  
Author(s):  
Leith Moxon-Lester ◽  
Kate Sinclair ◽  
Christopher Burke ◽  
Gary J. Cowin ◽  
Stephen E. Rose ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Newborn Piglets

scholarly journals Transcriptome Analysis of Intestinal Dysfunction in Newborn Piglets with Intrauterine Growth Restriction and Improve their Performance by Dimethylglycine Sodium Salt Supplementation after Weaning

2021 ◽  
Author(s):  
Kaiwen Bai ◽  
Luyi Jiang ◽  
Qiming Li ◽  
Jingfei Zhang ◽  
Lili Zhang ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Mitochondrial Function ◽  
Intrauterine Growth Restriction ◽  
Digestive Enzyme ◽  
Redox Status ◽  
Growth Restriction ◽  
Rna Seq ◽  
Weaned Piglets ◽  
Intrauterine Growth ◽  
Newborn Piglets

Abstract Background Few studies are available on the mechanism of intestinal dysfunction in newborn piglets with intrauterine growth restriction (IUGR). This work aimed to study the mechanism of jejunum dysfunction in IUGR newborn piglets through RNA-seq and improve their performance by dimethylglycine sodium salt (DMG-Na) supplementation after weaning. Methods In total, 13 normal birth weight (NBW) newborn piglets and 23 IUGR newborn piglets were obtained. Among them, 3 NBW and 3 IUGR newborn piglets were selected and stunned by electric shock after birth without suckling and collected the jejunum samples for RNA-sEq. After weaning at 21 days, they were randomly assigned to 3 groups (n = 10): NBW weaned piglets fed with common basal diets (N); IUGR weaned piglets fed with common basal diets (I); IUGR weaned piglets fed with common basal diets plus 0.1% DMG-Na (ID). All piglets are slaughtered at 49 days of age to collect serum and jejunum samples. Results The hub genes, including ATP8, C11orf86, CDKN1C, DDX58. HPX, INHBB, LECT2, ND1, NFIX, PRDM5, PSD3, SCD, and ZNF770, were found from the data analyzed by RNA-seq and WGCNA. Interestingly, we found ATP8 was the most significantly changed gene, which was crucial in maintaining mitochondrial function. After weaning, the growth performance of ID group was improved (P < 0.05) compared to that in I group. Jejunum histological morphology and its sub-organelle ultrastructure, serum immunoglobulin, jejunum sIgA level, and jejunum digestive enzyme activity were improved (P < 0.05) in ID group compared to those in I group. The redox status of serum, jejunum and its mitochondrial, as well as jejunum redox status-related and mitochondrial function-related gene expression level and protein content were improved (P < 0.05) in ID group in comparison to those in I group. Conclusion The activity of the SIRT1/PGC1α pathway was inhibited in the IUGR weaned piglets, which in turn leads to damage to their redox status and jejunum structure and function, and finally lowers their performance. The IUGR weaned piglets activate the SIRT1/PGC1α pathway by taking in the antioxidant substance like DMG-Na, thereby improving their unfavorable body state.

Abstract 130: Sphingosine-1-Phosphate Signaling Plays a Role in High Blood Pressure Programmed by Intrauterine Growth Restriction in Mouse

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Suttira Intapad
Keyword(s):  
Protein Expression ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Acute Administration ◽  
Mrna Levels ◽  
Male Control ◽  
Intrauterine Growth ◽  
Sphingosine 1 Phosphate ◽  
S1p Receptor

Intrauterine growth restriction (IUGR) is a risk factor for hypertension and cardiovascular (CV) disease in later life, but the underlying mechanisms remain unclear. The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is critically involved in CV development in the fetus, and plays a significant role in the regulation of CV health in adulthood. S1P receptor (S1PR) type 1, 2 and 3 are widely expressed in CV system which S1PR1 has a protective role against kidney injury, while S1PR3 is involved in controlling BP. Yet, the contribution of S1P on BP in IUGR is unknown. In the present studies, we tested the hypothesis that IUGR alters renal S1P receptors expression during- and post-nephrogenesis, which contributes to high BP in male IUGR mouse. C57bl/6J mice underwent sham or reduced uterine perfusion (RUP) at day 13 of gestation with delivery at full term. IUGR offspring (from RUP dam) had a lower birth weight than control (p<0.05). Kidneys were isolated from 2 day old male pups or adult 24 week old male control and IUGR. S1PR3 protein expression was increased in 2 day old IUGR kidneys (2.4 fold vs control, N=3, p< 0.01). At 24 weeks of age, S1PR3 mRNA levels were increased (1.2 fold vs control, N=4, p< 0.05) whereas S1PR3 protein levels were decreased (0.75 fold vs control, N=4, p< 0.05) in IUGR kidneys. mRNA and protein expression levels of S1PR1 and S1PR2 were not different between control and IUGR kidneys. Finally, we assessed the role of S1PRs agonist on BP of IUGR. Male IUGR offspring had a significantly higher BP compared to male control via carotid catheter in the conscious state (control: 112.1±2.1, IUGR: 125.0±3.7 mmHg; N=7, P <0.05). Acute administration of FTY720 (1 mg/kgBW i.p, Fingomod), a S1P receptor type 1, 3 agonist did not significantly alter BP in control (106.0 ± 5.7 mmHg) but significantly decreased BP in IUGR (105.7±2.3 mmHg, p< 0.05). A dose response to FTY720 (10 mg/kgBW) decreased BP in both control (94.0±2.0 mmHg, p< 0.05) and IUGR (99.3±2.3 mmHg, p< 0.05). Together our data suggest that IUGR programs an alteration of renal S1PR3 expression in both during- and post-nephrogenesis thereby contributing to an increase in sensitivity to S1PRs agonist. Thus, S1P signaling is a putative mechanism underlying the hypertension of IUGR offspring.

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

2016 ◽  
Vol 55 (1) ◽  
pp. 9-14 ◽  
Author(s):  
M. Vázquez‐Gómez ◽  
D. Valent ◽  
C. García‐Contreras ◽  
L. Arroyo ◽  
C. Óvilo ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Newborn Piglets ◽  
Brain Neurotransmitters

scholarly journals The Stomach Capacity is Reduced in Intrauterine Growth Restricted Piglets Compared to Normal Piglets

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1291
Author(s):  
Julie C. Lynegaard ◽  
Janni Hales ◽  
Marlene N. Nielsen ◽  
Christian F. Hansen ◽  
Charlotte Amdi
Keyword(s):  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Empty Stomach ◽  
Average Birth Weight ◽  
Intrauterine Growth ◽  
Newborn Piglets ◽  
Selection For ◽  
Head Morphology ◽  
Stomach Weight

Selection for increased litter sizes have decreased the average birth weight of piglets and up to 30% of newborn piglets in Danish herds show signs of intrauterine growth restriction (IUGR). It has been reported that around 48% of liveborn piglets dying between birth and weaning have empty stomachs, and that IUGR piglets do not ingest the recommended amount of colostrum to survive. The aim of this study was to investigate how much colostrum could be administrated depending on whether they were IUGR compared to normal piglets. Seventy-two piglets within 24 h of farrowing were classified as either IUGR or normal based on their head morphology. Stomach weight, length and capacity were measured along with bodyweight (BW). The results displayed a decreased BW, empty stomach weight and capacity in IUGR piglets, as well as a decreased relative stomach capacity in IUGR compared with normal piglets. In conclusion, birth weight is not the only factor influencing stomach capacity, and IUGR piglets have a smaller stomach capacity compared with normal piglets. It is estimated that IUGR piglets have the capacity to be given a bolus of 25 mL per kg/BW, whereas a normal piglet have a higher capacity (30 mL per kg/BW).

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