Intrauterine growth restriction due to uteroplacental vascular insufficiency leads to increased hypoxia-induced cerebral apoptosis in newborn piglets

2006 ◽  
Vol 1098 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Christopher Burke ◽  
Kate Sinclair ◽  
Gary Cowin ◽  
Stephen Rose ◽  
Betty Pat ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Newborn Piglets ◽  
Vascular Insufficiency

Renal Angiotensin Receptor Type 1 and 2 Upregulation in Intrauterine Growth Restriction of Newborn Piglets

2006 ◽  
Vol 182 (2) ◽  
pp. 106-114 ◽  
Author(s):  
Michael Rüster ◽  
Manfred Sommer ◽  
Günter Stein ◽  
Kathrin Bauer ◽  
Bernd Walter ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Receptor Type ◽  
Angiotensin Receptor ◽  
Intrauterine Growth ◽  
Newborn Piglets

Increased cerebral lactate during hypoxia may be neuroprotective in newborn piglets with intrauterine growth restriction

2007 ◽  
Vol 1179 ◽  
pp. 79-88 ◽  
Author(s):  
Leith Moxon-Lester ◽  
Kate Sinclair ◽  
Christopher Burke ◽  
Gary J. Cowin ◽  
Stephen E. Rose ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Newborn Piglets

scholarly journals Transcriptome Analysis of Intestinal Dysfunction in Newborn Piglets with Intrauterine Growth Restriction and Improve their Performance by Dimethylglycine Sodium Salt Supplementation after Weaning

2021 ◽  
Author(s):  
Kaiwen Bai ◽  
Luyi Jiang ◽  
Qiming Li ◽  
Jingfei Zhang ◽  
Lili Zhang ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Mitochondrial Function ◽  
Intrauterine Growth Restriction ◽  
Digestive Enzyme ◽  
Redox Status ◽  
Growth Restriction ◽  
Rna Seq ◽  
Weaned Piglets ◽  
Intrauterine Growth ◽  
Newborn Piglets

Abstract Background Few studies are available on the mechanism of intestinal dysfunction in newborn piglets with intrauterine growth restriction (IUGR). This work aimed to study the mechanism of jejunum dysfunction in IUGR newborn piglets through RNA-seq and improve their performance by dimethylglycine sodium salt (DMG-Na) supplementation after weaning. Methods In total, 13 normal birth weight (NBW) newborn piglets and 23 IUGR newborn piglets were obtained. Among them, 3 NBW and 3 IUGR newborn piglets were selected and stunned by electric shock after birth without suckling and collected the jejunum samples for RNA-sEq. After weaning at 21 days, they were randomly assigned to 3 groups (n = 10): NBW weaned piglets fed with common basal diets (N); IUGR weaned piglets fed with common basal diets (I); IUGR weaned piglets fed with common basal diets plus 0.1% DMG-Na (ID). All piglets are slaughtered at 49 days of age to collect serum and jejunum samples. Results The hub genes, including ATP8, C11orf86, CDKN1C, DDX58. HPX, INHBB, LECT2, ND1, NFIX, PRDM5, PSD3, SCD, and ZNF770, were found from the data analyzed by RNA-seq and WGCNA. Interestingly, we found ATP8 was the most significantly changed gene, which was crucial in maintaining mitochondrial function. After weaning, the growth performance of ID group was improved (P < 0.05) compared to that in I group. Jejunum histological morphology and its sub-organelle ultrastructure, serum immunoglobulin, jejunum sIgA level, and jejunum digestive enzyme activity were improved (P < 0.05) in ID group compared to those in I group. The redox status of serum, jejunum and its mitochondrial, as well as jejunum redox status-related and mitochondrial function-related gene expression level and protein content were improved (P < 0.05) in ID group in comparison to those in I group. Conclusion The activity of the SIRT1/PGC1α pathway was inhibited in the IUGR weaned piglets, which in turn leads to damage to their redox status and jejunum structure and function, and finally lowers their performance. The IUGR weaned piglets activate the SIRT1/PGC1α pathway by taking in the antioxidant substance like DMG-Na, thereby improving their unfavorable body state.

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

2016 ◽  
Vol 55 (1) ◽  
pp. 9-14 ◽  
Author(s):  
M. Vázquez‐Gómez ◽  
D. Valent ◽  
C. García‐Contreras ◽  
L. Arroyo ◽  
C. Óvilo ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Newborn Piglets ◽  
Brain Neurotransmitters

Fetal Cardiac Lipid Sensing Triggers an Early and Sex-Related Metabolic Energy Switch in Intrauterine Growth Restriction

2021 ◽  
Author(s):  
Loïze Maréchal ◽  
Benoit Sicotte ◽  
Véronique Caron ◽  
Michèle Brochu ◽  
André Tremblay
Keyword(s):  
Fatty Acids ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Metabolic Energy ◽  
Long Chain Fatty Acids ◽  
Intrauterine Growth ◽  
Lipidomic Analysis ◽  
Vascular Insufficiency ◽  
Long Chain ◽  
Chain Fatty Acids

Abstract CONTEXT Intrauterine growth restriction (IUGR) is an immediate outcome of an adverse womb environment, exposing newborns to developing cardiometabolic disorders later in life. This study investigates the cardiac metabolic consequences and underlying mechanism of energy expenditure in developing fetuses under conditions of IUGR. METHODS Using an animal model of IUGR characterized by uteroplacental vascular insufficiency, mitochondrial function, gene profiling, lipidomic analysis, and transcriptional assay were determined in fetal cardiac tissue and cardiomyocytes. RESULTS IUGR fetuses exhibited an upregulation of key genes associated with fatty acid breakdown and β-oxidation (Acadvl, Acadl, Acaa2), and mitochondrial carnitine shuttle (Cpt1a, Cpt2), instigating a metabolic gene reprogramming in the heart. Induction of Ech1, Acox1, Acox3, Acsl1, and Pex11a indicated a coordinated interplay with peroxisomal β-oxidation and biogenesis mainly observed in females, suggesting sexual dimorphism in peroxisomal activation. Concurring with the sex-related changes, mitochondrial respiration rates were stronger in IUGR female fetal cardiomyocytes, accounting for enhanced ATP production. Mitochondrial biogenesis was induced in fetal hearts with elevated expression of Ppargc1a transcript specifically in IUGR females. Lipidomic analysis identified accumulation of arachidonic, eicosapentaenoic, and docosapentaenoic polyunsaturated long-chain fatty acids in IUGR fetal hearts, which lead to nuclear receptor PPARα transcriptional activation in cardiomyocytes. Also, enrichment of H3K27ac chromatin marks to PPARα responsive metabolic genes in IUGR fetal hearts outlines an epigenetic control in the early metabolic energy switch. CONCLUSION These data are consistent with a premature and sex-related remodeling of cardiac metabolism in response to an unfavorable intrauterine environment, with specific long-chain fatty acids that may serve as predictive effectors leading to IUGR.

scholarly journals The Stomach Capacity is Reduced in Intrauterine Growth Restricted Piglets Compared to Normal Piglets

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1291
Author(s):  
Julie C. Lynegaard ◽  
Janni Hales ◽  
Marlene N. Nielsen ◽  
Christian F. Hansen ◽  
Charlotte Amdi
Keyword(s):  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Empty Stomach ◽  
Average Birth Weight ◽  
Intrauterine Growth ◽  
Newborn Piglets ◽  
Selection For ◽  
Head Morphology ◽  
Stomach Weight

Selection for increased litter sizes have decreased the average birth weight of piglets and up to 30% of newborn piglets in Danish herds show signs of intrauterine growth restriction (IUGR). It has been reported that around 48% of liveborn piglets dying between birth and weaning have empty stomachs, and that IUGR piglets do not ingest the recommended amount of colostrum to survive. The aim of this study was to investigate how much colostrum could be administrated depending on whether they were IUGR compared to normal piglets. Seventy-two piglets within 24 h of farrowing were classified as either IUGR or normal based on their head morphology. Stomach weight, length and capacity were measured along with bodyweight (BW). The results displayed a decreased BW, empty stomach weight and capacity in IUGR piglets, as well as a decreased relative stomach capacity in IUGR compared with normal piglets. In conclusion, birth weight is not the only factor influencing stomach capacity, and IUGR piglets have a smaller stomach capacity compared with normal piglets. It is estimated that IUGR piglets have the capacity to be given a bolus of 25 mL per kg/BW, whereas a normal piglet have a higher capacity (30 mL per kg/BW).

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