Magnetic Resonance Tracking of Transplanted Stem Cells in Rat Brain and Spinal Cord

2006 ◽  
Vol 3 (1-2) ◽  
pp. 62-67 ◽  
Author(s):  
Eva Syková ◽  
Pavla Jendelová
2004 ◽  
Vol 76 (2) ◽  
pp. 232-243 ◽  
Author(s):  
Pavla Jendelová ◽  
Vít Herynek ◽  
Lucia Urdzíková ◽  
Kateřina Glogarová ◽  
Jana Kroupová ◽  
...  

2008 ◽  
Vol 25 (1) ◽  
pp. 38-51 ◽  
Author(s):  
Jason T. Maikos ◽  
Ragi A.I. Elias ◽  
David I. Shreiber

Author(s):  
Sebastian Jessberger ◽  
Armin Curt ◽  
Roger A. Barker

A number of diseases of the brain and spinal cord are associated with substantial neural cell death and/or disruption of correct and functional neural networks. In the past, a variety of therapeutic strategies to rescue these systems have been proposed along with agents to induce functional plasticity within the remaining central nervous system (CNS) structures. In the case of injury or neurodegenerative disease these approaches have only met with limited success, indicating the need for novel approaches to treat diseases of the adult CNS. Recently, the idea of recruiting endogenous or transplanting stem cells to replace lost structures within the adult brain or spinal cord has gained significant attention, along with in situ reprogramming, and opened up novel therapeutic avenues in the context of regenerative medicine. Here we review recent advances in our understanding of how endogenous stem cells may be a part of pathological processes in certain neuropsychiatric diseases and summarize recent clinical and preclinical data suggesting that stem cell-based therapies hold great promise as a future treatment option in a number of diseases disrupting the proper function of the adult CNS.


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