scholarly journals Depot- and Gender-related Differences in the Lipolytic Pathway of Adipose Tissue from Severely Obese Patients

2006 ◽  
Vol 17 (3-4) ◽  
pp. 173-180 ◽  
Author(s):  
Joana M. Ramis ◽  
Ramón Salinas ◽  
José M. García-Sanz ◽  
José Moreiro ◽  
Ana M. Proenza ◽  
...  
2016 ◽  
Vol 6 (1) ◽  
Author(s):  
María Gómez-Serrano ◽  
Emilio Camafeita ◽  
Eva García-Santos ◽  
Juan A. López ◽  
Miguel A. Rubio ◽  
...  

2018 ◽  
Vol 25 (3) ◽  
pp. 219
Author(s):  
Bianca Codrina Morarasu ◽  
Raluca Ecaterina Haliga ◽  
Daniel Timofte ◽  
Ioana Hristov ◽  
Iustina Silivestru-Cretu ◽  
...  

2019 ◽  
Vol 91 (3) ◽  
pp. 400-410 ◽  
Author(s):  
Judith Brock ◽  
Andreas Schmid ◽  
Thomas Karrasch ◽  
Petra Pfefferle ◽  
Jutta Schlegel ◽  
...  

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Nicolas Linder ◽  
Alexander Schaudinn ◽  
Nikita Garnov ◽  
Matthias Blüher ◽  
Arne Dietrich ◽  
...  

2014 ◽  
Vol 46 ◽  
pp. 627-628
Author(s):  
Tamara E. Carver ◽  
Robert Bracewell ◽  
Olivier Babineau ◽  
Olivier Court ◽  
Ross E. Andersen

2014 ◽  
Vol 27 (9) ◽  
pp. 1123-1128 ◽  
Author(s):  
Nikita Garnov ◽  
Nicolas Linder ◽  
Alexander Schaudinn ◽  
Matthias Blüher ◽  
Thomas Karlas ◽  
...  

2010 ◽  
pp. P2-467-P2-467
Author(s):  
M Michalaki ◽  
V Kyriazopoulou ◽  
A Antonacopoulou ◽  
M Nikolaou ◽  
A Tsoukas ◽  
...  

Surgery ◽  
2006 ◽  
Vol 140 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Nana Gletsu ◽  
Edward Lin ◽  
Juan-Li Zhu ◽  
Leena Khaitan ◽  
Bruce J. Ramshaw ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Timon E. Adolph ◽  
Felix Grabherr ◽  
Lisa Mayr ◽  
Christoph Grander ◽  
Barbara Enrich ◽  
...  

Introduction. Obesity and related nonalcoholic fatty liver disease (NAFLD) are an emerging health care issue that imposes substantial morbidity to individuals. Growth and differentiation factor 15 (GDF15) limits food uptake, body weight, and energy balance by modulation of GDNF-family receptor α-like (GFRAL) signalling in the hindbrain. However, the regulation of GDF15 expression in obesity and NAFLD is incompletely understood. We sought to define the impact of weight loss achieved by laparoscopic adjustable gastric banding (LAGB) on hepatic and adipose GDF15 expression in a cohort of severely obese patients. Methods. We analysed GDF15 expression of liver and subcutaneous adipose tissue before and 6 months after LAGB in severely obese patients undergoing LAGB by quantitative real-time PCR. To assess the role of inflammation on GDF15 expression, we analysed Hep G2 hepatocytes stimulated with cytokines such as IL-1β, TNFα, IL-6, LPS, or cellular stressors such as tunicamycin. Results. GDF15 expression was mostly confined to the liver compared to adipose tissue in severely obese patients. Weight loss induced by LAGB was associated with reduced hepatic (but not adipose tissue) expression of GDF15. Stimulation with IL-1β or tunicamycin induced hepatic GDF15 expression in hepatocytes. In line with this, hepatic GDF15 expression directly correlated with IL-1β expression and steatosis severity in NAFLD. These data demonstrated that amelioration of metabolic inflammation and weight loss reduced hepatic GDF15 expression. Conclusion. Based on recent mechanistic findings, our data suggest that hepatic GDF15 may serve as a negative feedback mechanism to control energy balance in NAFLD.


Sign in / Sign up

Export Citation Format

Share Document