scholarly journals Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
María Gómez-Serrano ◽  
Emilio Camafeita ◽  
Eva García-Santos ◽  
Juan A. López ◽  
Miguel A. Rubio ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Obese Patients ◽  
And Gender ◽  
Gender Specific

scholarly journals Age and gender specific estimation of visceral adipose tissue amounts from radiological images in morbidly obese patients

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Nicolas Linder ◽  
Alexander Schaudinn ◽  
Nikita Garnov ◽  
Matthias Blüher ◽  
Arne Dietrich ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Age And Gender ◽  
Radiological Images ◽  
And Gender ◽  
Visceral Adipose ◽  
Gender Specific

Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients

BioFactors ◽  
2016 ◽  
Vol 42 (4) ◽  
pp. 397-406 ◽  
Author(s):  
Michio Shimabukuro ◽  
Hiromi Sato ◽  
Hirofumi Izaki ◽  
Daiju Fukuda ◽  
Etsuko Uematsu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cancer Patients ◽  
Nlrp3 Inflammasome ◽  
Toll Like Receptors ◽  
Specific Expression ◽  
And Gender ◽  
Gender Specific

P2-107 Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner

2007 ◽  
Vol 83 ◽  
pp. S159
Author(s):  
M. Penza ◽  
C. Montani ◽  
M. Jeremic ◽  
V. Bicelli ◽  
V. Mazzone ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Specific Manner ◽  
And Gender ◽  
Dose Dependent ◽  
Gender Specific

scholarly journals Depot- and Gender-related Differences in the Lipolytic Pathway of Adipose Tissue from Severely Obese Patients

2006 ◽  
Vol 17 (3-4) ◽  
pp. 173-180 ◽  
Author(s):  
Joana M. Ramis ◽  
Ramón Salinas ◽  
José M. García-Sanz ◽  
José Moreiro ◽  
Ana M. Proenza ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Obese Patients ◽  
Severely Obese ◽  
And Gender

scholarly journals Genistein Affects Adipose Tissue Deposition in a Dose-Dependent and Gender-Specific Manner

Endocrinology ◽  
2006 ◽  
Vol 147 (12) ◽  
pp. 5740-5751 ◽  
Author(s):  
M. Penza ◽  
C. Montani ◽  
A. Romani ◽  
P. Vignolini ◽  
B. Pampaloni ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Receptor Expression ◽  
Peripheral Insulin Resistance ◽  
Specific Manner ◽  
Phospholipid Transfer ◽  
Gene Microarray Analysis ◽  
And Gender ◽  
Responsive Element ◽  
Almost All ◽  
Gender Specific

The soy isoflavone genistein targets adipose tissue and elicits physiological effects that may vary based on dietary intake. We hypothesized that the adipose effects of genistein are dose and gender dependent. Four-week-old C57BL/6 male and female mice received daily oral doses of genistein (50–200,000 μg/kg·d) or 17β-estradiol (E2) (5 μg/kg·d) for 15 d or a diet containing 800 ppm genistein. Genistein increased epididymal and renal fat pad and adipocyte size at doses up to 50,000 μg/kg·d or at 800 ppm in the diet in males but not in females. The alteration in adipocity correlated with changes in peripheral insulin resistance. These treatments increased genistein serum concentrations from 35 ± 6 to 103 ± 26 nm 12 h after treatment and lowered plasma triglycerides and cholesterol levels. The 200,000 μg/kg·d genistein dose decreased adipose tissue weight similarly to E2. This genistein dose down-regulated estrogen receptor (β more than α) and progesterone receptor expression and induced estrogen-dependent adipose differentiation factors; it did not change expression of the minimal consensus estrogen-responsive element in ERE-tK-LUC mice, which was positively modulated in other tissues (e.g. the lung). E2 down-regulated almost all examined adipogenic factors. Gene microarray analysis identified factors in fat metabolism and obesity-related phenotypes differentially regulated by low and high doses of genistein, uncovering its adipogenic and antiadipogenic actions. The lower dose induced the phospholipase A2 group 7 and the phospholipid transfer protein genes; the 200,000 μg/kg·d dose inhibited them. The antiadipogenic action of genistein and down-regulation of adipogenic genes required the expression of ERβ. In conclusion, nutritional doses of genistein are adipogenic in a gender-specific manner, whereas pharmacological doses inhibited adipose deposition.

1603-P: Changes in Age- and Gender-Specific All-Cause Mortality Rates and Ratios in People with T2DM in Hungary between 2001-2016: A Nationwide Cohort Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1603-P
Author(s):  
GYORGY JERMENDY ◽  
ZOLTAN KISS ◽  
GYÖRGY ROKSZIN ◽  
IBOLYA FÁBIÁN ◽  
ISTVAN WITTMANN ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mortality Rates ◽  
Age And Gender ◽  
All Cause Mortality ◽  
And Gender ◽  
Gender Specific

Sex and Gender Differences in Rilpivirine based ART - Data from the HIVCENTER Frankfurt

2019 ◽  
Vol 17 (5) ◽  
pp. 368-374
Author(s):  
G. Schüttfort ◽  
K. Philipp ◽  
P. de Leuw ◽  
E. Herrmann ◽  
G. Kann ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Virologic Failure ◽  
Response Rates ◽  
Virologic Response ◽  
Close Monitoring ◽  
Sex And Gender ◽  
Overall Response ◽  
Number Of Patients ◽  
And Gender ◽  
Gender Specific

Objectives: While Rilpivirine has shown high overall response rates in treatment-naïve patients without sex and gender specific differences in clinical trials, Sex and gender specific data in treatment experienced patients receiving rilpivirine are still limited. We conducted a 48 week efficacy and safety analysis in naïve and treatment experienced men and women using retrospective data from the HIVCENTER Frankfurt. Materials and methods: In this retrospective observational study data of all patients who received a rilpivirine based regimen at the HIVCENTER between March 2011 and December 2015 were analyzed. Primary endpoint was the proportion of patients with any discontinuation until week 48. Virologic response rates (FDA snapshot analysis; HIV-1 RNA <50 copies/mL) were assessed at week 48. Results: 194 patients (34% female) were included in the analysis. 74% were treatment-experienced and 26% naïve, respectively. Discontinuations were observed in 31 (15.9%) patients. Regarding sex differences, the proportion of discontinuations was significantly higher in women than in men (24.2% vs. 11.7%; p=0.024; ODDS-Ratio = 2.41; CI 1.12 – 5.18). Virologic failure occurred in 8 PLWHIV (4.1%). Conclusions: While virologic overall response rates to rilpivirine based ART were high for both treatment-experienced and -naïve patients the proportion of discontinuations was significantly higher in women (24.2% vs. 11.7%; p = 0.024; ODDS-Ratio = 2.41; CI 1.12 – 5.18). Although the total number of patients with virologic failure was low (4.1%), the higher rate of ART discontinuations in female patients receiving RPV require close monitoring in the first months of treatment addressing special needs of women living with HIV.

scholarly journals The Prevalence and Patterns of Palmaris Longus Muscle Absence in an Iranian Population

2019 ◽  
Vol 9 (4) ◽  
pp. 279-282
Author(s):  
Mehdi Forouzesh ◽  
Abdolrazagh Barzegar ◽  
Fardin Fallah
Keyword(s):  
Gender Difference ◽  
Clinical Importance ◽  
Tendon Graft ◽  
Iranian Population ◽  
Geographical Variability ◽  
Palmaris Longus ◽  
Longus Muscle ◽  
Palmaris Longus Muscle ◽  
And Gender ◽  
Gender Specific

Palmaris Longus (PL) is a muscle of the forearm, i.e., not functionally necessary and does not exist in all people. It is a choice for tendon graft and investigating its prevalence is of clinical importance. During April-October 2009, 102 cadavers (78 males, 24 females) were bilaterally necropsied for PL exploration in Zanjan City, Iran. PL Absence (PLA) was observed in 37 (36.3%) cases (28 males, 9 females). PLA prevalence was similar in men (36%) and women (37.5%). Of PLA cases, 19 (51%) were unilateral (14 males, 5 females), and 18 (49%) were bilateral (14 males, 4 females). In conclusion, PLA prevalence of 36.3% in our population was similar to other studies conducted in Iran. We found no gender difference in PLA prevalence and its patterns. Due to geographical variability in PLA rate, future regional and national studies with more magnificent sample sizes are recommended to determine the prevalence and gender-specific patterns of PLA.

scholarly journals Epicardial adipose tissue differentiates in patients with and without coronary microvascular dysfunction

2021 ◽  
Author(s):  
Ihab Mahmoud ◽  
Iryna Dykun ◽  
Luisa Kärner ◽  
Stefanie Hendricks ◽  
Matthias Totzeck ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Regression Analysis ◽  
Epicardial Adipose Tissue ◽  
Obstructive Coronary Artery Disease ◽  
Age Groups ◽  
Microvascular Dysfunction ◽  
Coronary Microvascular Dysfunction ◽  
Local Inflammation ◽  
And Gender ◽  
Fat Depot

Abstract Background/Objectives Coronary microvascular dysfunction (CMD) is a common disorder, leading to symptoms similar to obstructive coronary artery disease and bears important prognostic implications. Local inflammation is suggested to promote development of CMD. Epicardial adipose tissue (EAT) is a local visceral fat depot surrounding the heart and the coronary arteries, modifying the inflammatory environment of the heart. We compared EAT in patients with and without CMD. Methods We retrospectively included consecutive patients undergoing diagnostic coronary angiography as well as transthoracic echocardiography between March and October 2016. EAT thickness was defined as space between the epicardial wall of the myocardium and the visceral layer of the pericardium and EAT index was calculated as EAT thickness/body surface area. Logistic regression analysis was used to determine the association of EAT index with the presence of CMD. Results Overall, 399 patients (mean age 60.2 ± 14.0 years, 46% male) were included. EAT thickness was significantly higher in patients with CMD compared to patients without CMD (EAT thickness 4.4 ± 1.8 vs. 4.9 ± 2.4 mm, p = 0,048 for patients without and with CMD, respectively). In univariate regression analysis, EAT index was associated with a 30% higher frequency of CMD (odds ratio [95% confidence interval]: 1.30 [1.001–1.69], p = 0.049). Effect sizes remained stable upon adjustment for body mass index (BMI, 1.30 [1.003–1.70], p = 0.048), but were attenuated when ancillary adjusting for age and gender (1.17 [0.90–1.54, p = 0.25). The effect was more pronounced in patients >65 years of age and independent of BMI and sex (1.85 [1.14–3.00], p = 0.013). Conclusion EAT thickness is independently associated with CMD and can differentiate between patients with and without CMD especially in older age groups. Our results support the hypothesis that modulation of local inflammation by epicardial fat is involved in the development of CMD.

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