Analysis of Prognostic Factors of Chemoradiation Therapy for Advanced Hypopharyngeal Cancer – Does Tumor Volume Correlate with Central Necrosis and Tumor Pathology?

ORL ◽  
2006 ◽  
Vol 68 (4) ◽  
pp. 206-212 ◽  
Author(s):  
Yung An Tsou ◽  
Jun Hong Hua ◽  
Meng Hung Lin ◽  
Ming Hsui Tsai
Keyword(s):  
Prognostic Factors ◽  
Tumor Volume ◽  
Hypopharyngeal Cancer ◽  
Chemoradiation Therapy ◽  
Central Necrosis ◽  
Tumor Pathology

scholarly journals Prognostic factors after transoral resection of early hypopharyngeal cancer

2021 ◽  
Author(s):  
Keisuke Iritani ◽  
Daryl Anne A. Mundo ◽  
Shinobu Iwaki ◽  
Kuriko Masuda ◽  
Maki Kanzawa ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Hypopharyngeal Cancer ◽  
Transoral Resection

Hearing preservation following fractionated stereotactic radiotherapy for vestibular schwannomas: prognostic implications of cochlear dose

2007 ◽  
Vol 107 (5) ◽  
pp. 917-926 ◽  
Author(s):  
Carys Thomas ◽  
Salvatore Di Maio ◽  
Roy Ma ◽  
Emily Vollans ◽  
Christina Chu ◽  
...  
Keyword(s):  
At Risk ◽  
Prognostic Factors ◽  
Stereotactic Radiotherapy ◽  
Tumor Volume ◽  
Intensity Modulated Radiotherapy ◽  
Hearing Preservation ◽  
Fractionated Stereotactic Radiotherapy ◽  
Significant Prognostic Factor ◽  
Organ At Risk ◽  
Radiotherapy Dose

Object The goal in this study was to evaluate hearing preservation rates and to determine prognostic factors for this outcome following fractionated stereotactic radiotherapy (FSRT) of vestibular schwannoma. Methods Thirty-four consecutive patients with serviceable hearing who received FSRT between May 1998 and December 2003 were identified. Clinical and audiometry data were collected prospectively. The prescription dose was 45 Gy in 25 fractions prescribed to the 90% isodose line. The median follow-up duration was 36.5 months (range 12–85 months). The actuarial 2- and 4-year local control rates were 100 and 95.7%, respectively. Permanent trigeminal and facial nerve complications were 0 and 6%, respectively. The actuarial 2- and 3-year serviceable hearing preservation rates were both 63%. The median loss in speech reception threshold was 15 dB (range −10 to 65 dB). The radiotherapy dose to the cochlea was the only significant prognostic factor for hearing deterioration. Radiotherapy dose to the cochlear nucleus, patient age, sex, pre-FSRT hearing grade, tumor volume, and intracanalicular tumor volume failed to show any significance as prognostic factors. Results Five cases were replanned with four different radiotherapy techniques (namely arcs, dynamic arcs, static conformal fields, and intensity-modulated radiotherapy), with the cochlea defined as an organ at risk. In all cases, replanning resulted in statistically significant reduction in radiation to the cochlea (p = 0.001); however, no single replanning technique was found to be superior. Conclusions The radiation dose to the cochlea is strongly predictive for subsequent hearing deterioration. It is essential for the cochlea to be outlined as an organ at risk, and for radiation techniques to be optimized, to improve long-term hearing preservation.

THE INFLUENCE OF VOLUMETRIC TUMOR DOUBLING TIME ON SURVIVAL OF PATIENTS WITH INTRACRANIAL TUMORS

2021 ◽  
pp. 39-43
Author(s):  
Yadav Ambica ◽  
Tandon Anupama
Keyword(s):  
Prognostic Factors ◽  
Doubling Time ◽  
Tumor Volume ◽  
Histological Grade ◽  
Tumor Location ◽  
P Value ◽  
Intracranial Tumors ◽  
Excellent Correlation ◽  
Tumor Doubling Time ◽  
Initial Tumor

Objective:To evaluate inuence of volumetric tumor doubling time on survival of patients with intracranial tumors. Study design: 20 patients with intracranial tumor of either sex and any age were included, if two imaging scans were available/could be done in which change in tomor volume was appreciable and the tumor margins were well demarcated. Based on change in tumor volume, tumor doubling time (DT) and predictive survival time (PST) were calculated. Patients were followed up for 6 months or longer for actual survival time (AST). Results: The histological grade was found to have a signicant correlation with DT (P value 0.046) and PST of the tumor (P value 0.038). DT and PSTwere found to be signicantly lower in high grade astrocytomas. Age, gender, tumor location and initial tumor volume were not found to have a signicant correlation with DTand PST. When DTwas compared to PST, excellent correlation was seen which was statistically signicant (Pvalue < 0.001) and suggested a linear relationship. Conclusion: Computed Tomography (CT) & Magnetic Resonance Imaging (MRI) can accurately dene the intracranial tumors and can reliably measure their volume. Calculation of tumor volume, change in tumor volume, DT and PST based on imaging studies is easy and reproducible. DT and PST have an excellent correlation & there is a linear relationship between the two. Histological grade and DT are the signicant prognostic factors while age, gender, tumor location and initial tumor volume are not signicant prognostic factors in patients with brain tumors.

scholarly journals Prognostic Factors for Overall Survival in Advanced Intrahepatic Cholangiocarcinoma Treated with Yttrium-90 Radioembolization

2019 ◽  
Vol 9 (1) ◽  
pp. 56 ◽  
Author(s):  
Michael Köhler ◽  
Fabian Harders ◽  
Fabian Lohöfer ◽  
Philipp M. Paprottka ◽  
Benedikt M. Schaarschmidt ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Liver Disease ◽  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Tumor Volume ◽  
Cox Regression ◽  
Tertiary Care ◽  
Liver Volume ◽  
Total Liver Volume

Purpose: To evaluate factors associated with survival following transarterial 90Y (yttrium) radioembolization (TARE) in patients with advanced intrahepatic cholangiocarcinoma (ICC). Methods: This retrospective multicenter study analyzed the outcome of three tertiary care cancer centers in patients with advanced ICC following resin microsphere TARE. Patients were included either after failed previous anticancer therapy, including relapse after surgical resection, or for having a minimum of 25% of total liver volume affected by ICC. Patients were stratified and response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) criteria at 3 months. Kaplan–Meier analysis was performed to analyze survival followed by cox regression to determine independent prognostic factors for survival. Results: 46 patients were included (19 male, 27 female), median age 62.5 years (range 29–88 years). A total of 65% of patients had undergone previous therapy, while 63% had a tumor volume > 25% of the entire liver volume. Median survival was 9.5 months (95% CI: 6.1–12.9 months). Due to loss in follow-up, n = 37 patients were included in the survival analysis. Cox regression revealed the extent of liver disease to one or both liver lobes being associated with survival, irrespective of tumor volume (p = 0.041). Patients with previous surgical resection of ICC had significantly decreased survival (3.9 vs. 12.8 months, p = 0.002). No case of radiation-induced liver disease was observed. Discussion: Survival after 90Y TARE in patients with advanced ICC primarily depends on disease extent. Only limited prognostic factors are associated with a general poor overall survival.

scholarly journals Prognostic factors in glioblastoma multiforme

2010 ◽  
Vol 29 (04) ◽  
pp. 121-125 ◽  
Author(s):  
Leonardo Welling ◽  
José Carlos Lynch ◽  
Celestino Pereira ◽  
Ricardo Andrade ◽  
Fabiana Polycarpo Hidalgo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Glioblastoma Multiforme ◽  
Retrospective Analysis ◽  
Tumor Volume ◽  
Standard Treatment ◽  
Karnofsky Performance Status ◽  
Performance Status ◽  
Surgical Techniques ◽  
The Other ◽  
Tumor Removal

Abstract Objective: To study if the prognosis variables such as age, the Karnofsky Performance Status (KPS), extension of tumor removal by surgery, radiotherapy and tumor volume influenced the survival of patients with glioblastoma multiforme (GBM). Method: Retrospective analysis of GBM patients operated at Hospital dos Servidores do Estado between 1998 and 2008. Results: We could observe that age, the KPS and radiotherapy influenced the survival. The other variables did not have any prognosis implications. Conclusions: Despite many researches and many improvements regarding the diagnosis and the surgical techniques, the survival of patients with GBM has not changed in the last 30 years and is a therapeutic challenge. The surgical resection followed by radiotherapy is the standard treatment for patients with GBM. The importance of each variable in the patient's prognosis is still to be established in the multivariate analyzes.

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