Association between β2-Adrenergic Receptor Genetic Polymorphisms and Nocturnal Asthmatic Patients of Chinese Han Nationality

Respiration ◽  
2006 ◽  
Vol 73 (4) ◽  
pp. 464-467 ◽  
Author(s):  
Kaisheng Yin ◽  
Xilong Zhang ◽  
Yuying Qiu
Keyword(s):  
Genetic Polymorphisms ◽  
Adrenergic Receptor ◽  
Chinese Han ◽  
Asthmatic Patients ◽  
Han Nationality

scholarly journals Effect of β2 -adrenergic receptor gene Arg16Gly polymorphisms on response to long-acting β2-agonist in Chinese Han asthmatic patients

2014 ◽  
Vol 9 ◽  
Author(s):  
Yuying Qiu ◽  
Deping Zhang ◽  
Yu Qin ◽  
Kai-Sheng Yin
Keyword(s):  
Fluticasone Propionate ◽  
Asthma Control ◽  
Adrenergic Receptor ◽  
Inhaled Corticosteroids ◽  
Receptor Gene ◽  
Chinese Han ◽  
Asthmatic Patients ◽  
Significant Difference ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Gene

Background: To evaluate the effect of variation of the Arg16Gly polymorphism of the β2-adrenergic receptor gene on clinical response to salmeterol administered with fluticasone propionate in Chinese Han asthmatic patients. Methods: Moderate persistent asthmatic patients (n = 62) currently receiving short-acting β2-agonists were administered twice-daily therapy with salmeterol/fluticasone propionate 50/250 μg in a single inhaler for 12 weeks, followed by a 2-to-4-day run-out period. Using direct DNA sequencing, five single nucleotide polymorphisms (SNPs) in the promoter and coding block regions of β2-adrenergic receptor gene were determined in 62 subjects and haplotypes were combined. Results: There was sustained and significant improvement (p < 0.001) over baseline in all measures of asthma control in subjects receiving salmeterol and fluticasone, regardless of Arg16Gly genotype. However, there was no significant difference in the improvement among three genotypes (p > 0.05). Responses to salmeterol did not appear to be modified by haplotype pairs (p > 0.05). During the run-out period, all subjects had similar decreases in measures of asthma control, with no differences between genotypes (p > 0.05). Conclusions: Response to salmeterol does not vary with Arg16Gly polymorphisms after chronic dosing with inhaled corticosteroids in Chinese Han asthmatic patients.

Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province

2014 ◽  
Vol 34 (10) ◽  
pp. 1729-1736 ◽  
Author(s):  
Xinglin Yang ◽  
Ming Li ◽  
Liya Wang ◽  
Zhongdan Hu ◽  
Yuanchao Zhang ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Genetic Polymorphisms ◽  
Shandong Province ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Genetic polymorphisms of 20 STR loci in Chinese Han population in Tianjin, North China

2013 ◽  
Vol 4 (1) ◽  
pp. e192-e193 ◽  
Author(s):  
Bin Wang ◽  
Jinzhi Kuang ◽  
Yan Ma ◽  
Guimin Wang ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
North China ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Str Loci
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