Association between β2-Adrenergic Receptor Genetic Polymorphisms and Total Serum IgE in Asthmatic Patients of Chinese Han Nationality

Respiration ◽  
2006 ◽  
Vol 73 (2) ◽  
pp. 180-184 ◽  
Author(s):  
Yu-ying Qiu ◽  
Xi-Long Zhang ◽  
Kai-Sheng Yin
Keyword(s):  
Genetic Polymorphisms ◽  
Adrenergic Receptor ◽  
Total Serum ◽  
Chinese Han ◽  
Serum Ige ◽  
Asthmatic Patients ◽  
Han Nationality

scholarly journals The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients

2012 ◽  
Vol 129 (2) ◽  
pp. 575-578.e9 ◽  
Author(s):  
Xingnan Li ◽  
Elizabeth J. Ampleford ◽  
Timothy D. Howard ◽  
Wendy C. Moore ◽  
Huashi Li ◽  
...  
Keyword(s):  
Total Serum ◽  
Serum Ige ◽  
Asthmatic Patients

scholarly journals Relationship between pulmonary function tests, sputum eosinophilia and total serum IgE levels among asthmatic patients in Duhok, Iraq

2020 ◽  
Vol 8 (6) ◽  
pp. 2033
Author(s):  
Hamdia Yousif Issa ◽  
Ali A. Ramadhan ◽  
Abdulazeez S. Safo ◽  
Omar A. M. Al Habib
Keyword(s):  
Pulmonary Function ◽  
Severe Asthma ◽  
Inflammatory Markers ◽  
Pulmonary Function Tests ◽  
Asthma Severity ◽  
Total Serum ◽  
Serum Ige ◽  
Sputum Eosinophilia ◽  
Asthmatic Patients ◽  
Function Tests

Background: Bronchial asthma is a disease characterized by reversible airway obstruction, airway inflammation; and hyper-responsiveness. The prevalence of asthma is high, and both its prevalence and burden have increased over the last several decades. The study of inflammatory markers has implications for the appropriate management of this disease. Inflammatory markers has implications for the appropriate management of this disease. Objective of the study is to determine the correlation between asthma severity using pulmonary function tests with sputum eosinophilia and total serum IgE levels.Methods: This case-control study was conducted from March 2017 to September 2018 in the respiratory unit of Azadi general teaching hospital. It included 42 asthmatic patients and 18 healthy subjects. They underwent pulmonary function tests and measurement of total serum IgE levels. Induced sputum was done for asthmatic patients.Results: The age of asthmatic patients ranged from 16-70 years (mean 42±19 years). The asthmatic patient’s female: male ratio was 1.8. Mild asthma was the most common severity group (N=18, 43%) followed by moderate asthma (N=14, 33%) then severe asthma (N=10, 24%). Abnormal sputum eosinophilia (≥3%) was detected in 90% of severe asthma (N=9) compared to 36% in moderate asthma (N=5) and 5.6% in mild asthma (N=1). There was significant statistical association between asthma severity and sputum eosinophilia (p=0.00004). The association between asthma severity and total serum IgE levels was highly significant (p<0.0000) with levels of total serum IgE increasing as the severity of asthma increases.Conclusions: Severe asthma is the least common severity group in this study. Both abnormal sputum eosinophilia and total serum IgE levels are associated with the severity of asthma.

Variability of total serum IgE in moderate-to-severe asthmatic patients

2016 ◽  
Author(s):  
Renaud Louis ◽  
Charles Pilette ◽  
Olivier Michel ◽  
Alain Michils ◽  
Guy Brusselle ◽  
...  
Keyword(s):  
Total Serum ◽  
Serum Ige ◽  
Asthmatic Patients ◽  
Severe Asthmatic

Additive association between FCER1A and FCER1B genetic polymorphisms and total serum IgE levels

Allergy ◽  
2007 ◽  
Vol 62 (9) ◽  
pp. 1095-1096 ◽  
Author(s):  
D. P. Potaczek ◽  
M. Sanak ◽  
A. Szczeklik
Keyword(s):  
Genetic Polymorphisms ◽  
Total Serum ◽  
Serum Ige

scholarly journals Effect of β2 -adrenergic receptor gene Arg16Gly polymorphisms on response to long-acting β2-agonist in Chinese Han asthmatic patients

2014 ◽  
Vol 9 ◽  
Author(s):  
Yuying Qiu ◽  
Deping Zhang ◽  
Yu Qin ◽  
Kai-Sheng Yin
Keyword(s):  
Fluticasone Propionate ◽  
Asthma Control ◽  
Adrenergic Receptor ◽  
Inhaled Corticosteroids ◽  
Receptor Gene ◽  
Chinese Han ◽  
Asthmatic Patients ◽  
Significant Difference ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Gene

Background: To evaluate the effect of variation of the Arg16Gly polymorphism of the β2-adrenergic receptor gene on clinical response to salmeterol administered with fluticasone propionate in Chinese Han asthmatic patients. Methods: Moderate persistent asthmatic patients (n = 62) currently receiving short-acting β2-agonists were administered twice-daily therapy with salmeterol/fluticasone propionate 50/250 μg in a single inhaler for 12 weeks, followed by a 2-to-4-day run-out period. Using direct DNA sequencing, five single nucleotide polymorphisms (SNPs) in the promoter and coding block regions of β2-adrenergic receptor gene were determined in 62 subjects and haplotypes were combined. Results: There was sustained and significant improvement (p < 0.001) over baseline in all measures of asthma control in subjects receiving salmeterol and fluticasone, regardless of Arg16Gly genotype. However, there was no significant difference in the improvement among three genotypes (p > 0.05). Responses to salmeterol did not appear to be modified by haplotype pairs (p > 0.05). During the run-out period, all subjects had similar decreases in measures of asthma control, with no differences between genotypes (p > 0.05). Conclusions: Response to salmeterol does not vary with Arg16Gly polymorphisms after chronic dosing with inhaled corticosteroids in Chinese Han asthmatic patients.

scholarly journals The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients

2021 ◽  
Vol 11 (5) ◽  
pp. 329
Author(s):  
Malek Zihlif ◽  
Amer Imraish ◽  
Baeth Al-Rawashdeh ◽  
Aya Qteish ◽  
Raihan Husami ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Immunoglobulin E ◽  
Allergic Diseases ◽  
Total Serum ◽  
P Value ◽  
Asthmatic Patients ◽  
Minor Alleles ◽  
Adults And Children ◽  
Polymerase Chain ◽  
Control Study

Total serum immunoglobulin E (IgE) is elevated in multiple allergic diseases and is considered a good predictor of atopy. Several studies have been performed on the association of IgE levels with the polymorphism of the ADAM33 gene in asthmatic patients. The aim of this study was to determine whether there is an association between IgE levels and the genetic polymorphisms of the ADAM33 gene (T1, T2, T + 1, V4, S1, S2, and Q-1) in both healthy and asthmatic patients among Jordanians. The clinical data were collected for this case–control study from 267 asthmatic patients and 225 control subjects. Seven genetic polymorphisms (T1, T2, T + 1, V4, S1, S2, and Q-1) of the gene ADAM33 were analyzed using the polymerase chain reaction/restriction fragment length polymorphism method. The minor alleles (G) of T1, (A) of T2, T + 1, and (G) of V4 polymorphisms were associated with a significant increase in total serum IgE levels in adults but not children. The V4 genetic polymorphism, however, showed a significant association with IgE levels in both adults and children. The S1 polymorphism was significantly associated with the codominant module only in the adults. The S2 polymorphism showed a significant association (p-value < 0.05) in both codominant and recessive models. However, in the dominant model for both pediatric control and asthmatic patients, the association between the IgE and S2 polymorphism was insignificant (p-value = 0.7271 and 0.5259, respectively). This study found a statistically significant association between multiple ADAM33 genetic polymorphisms and IgE levels. Such findings add to the growing evidence that the ADAM33 gene has a major impact on IgE levels among asthmatic patients of Jordanian origin.

GENETIC POLYMORPHISMS OF THE NOVEL FCER1A GENE REGION: RELATION TO TOTAL SERUM IgE LEVELS

2007 ◽  
Vol 98 (5) ◽  
pp. 500-501 ◽  
Author(s):  
Daniel P. Potaczek ◽  
Marek Sanak ◽  
Lucyna Mastalerz ◽  
Mamert Milewski ◽  
Agnieszka Gawlewicz-Mroczka ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Gene Region ◽  
Total Serum ◽  
The Novel ◽  
Serum Ige
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