Antimicrobial Peptides in Human Skin

2005 ◽  
pp. 22-41 ◽  
Author(s):  
Jürgen Harder ◽  
Jens-Michael Schröder
Keyword(s):  
Antimicrobial Peptides ◽  
Human Skin

scholarly journals Tape stripping method is useful for the quantification of antimicrobial peptides on the human skin surface including the stratum corneum

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shigeyuki Ono ◽  
Nobuhiko Eda ◽  
Takuya Mori ◽  
Atsuko Otsuka ◽  
Nobuhiro Nakamura ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Stratum Corneum ◽  
Human Skin ◽  
Significant Positive Correlation ◽  
Skin Surface ◽  
Tape Stripping ◽  
Established Method ◽  
Positive Correlation ◽  
Physiological Importance ◽  
Stripping Method

Abstract Antimicrobial peptides (AMPs) play an important role in innate immunity in human skin. It is known that AMPs mainly function in the stratum corneum. Therefore, AMP concentrations in the stratum corneum need to be precisely measured to clarify functional and physiological importance of AMPs in cutaneous defence. Tape stripping (TS) is a well-established method by which components in the stratum corneum can be collected. However, the usefulness of the TS method for measuring AMP concentration in human skin remains unclear. Therefore, we compared it with another popular method, skin rinsing, which had been established as a method for measuring AMP concentration in human skin. When investigated on healthy medial forearm using RNase 7, which is one of the typical AMPs, as an index, there was a significant positive correlation between RNase 7 concentrations measured by the TS method at adjacent forearm sites, demonstrating the reproducibility of the TS method. Next, a significant positive correlation was detected in RNase 7 concentrations measured using the TS and the skin rinsing method, indicating that the TS method is comparable to the skin rinsing method. Thus, we speculate that the TS method is useful for measuring AMP concentration in human skin.

Percutaneous Biomedical Device with a Regenerative Materials Interface

2008 ◽  
Vol 1136 ◽  
Author(s):  
Antonio Peramo ◽  
Cynthia L. Marcelo ◽  
Steve Goldstein ◽  
David C. Martin
Keyword(s):  
Stainless Steel ◽  
Antimicrobial Peptides ◽  
Human Skin ◽  
Culture System ◽  
Local Administration ◽  
Junctional Epithelium ◽  
Biomedical Device ◽  
Skin Explants

ABSTRACTWe have developed an in vitro culture system composed of organotypic human skin explants interfaced with titanium rods or stainless steel fixator pins. The use of this interface provides a model to evaluate strategies for creating a stable, long-term connection with living skin and chronic percutaneous devices. Our hypothesis is that the delivery of specific biomaterials at this interface will create a dynamic, slowly flowing matrix for skin biointegration, local administration of drugs or antimicrobials. We define this concept as the generation of an artificial mucosa, because it mimics the situation of several epithelial tissues (like the periodontal junction between the tooth and the junctional epithelium) where antimicrobial peptides and mucins are constantly extruded.

Role of Human Skin Antimicrobial Peptides in Psoriasis

2010 ◽  
Vol 10 (2) ◽  
Author(s):  
Elga Mozeika ◽  
Mara Pilmane ◽  
Janis Kisis
Keyword(s):  
Antimicrobial Peptides ◽  
Human Skin

scholarly journals Differential expression andin vivosecretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin

2013 ◽  
Vol 22 (5) ◽  
pp. 364-366 ◽  
Author(s):  
Maike Wittersheim ◽  
Jesko Cordes ◽  
Ulf Meyer-Hoffert ◽  
Jürgen Harder ◽  
Jürgen Hedderich ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Differential Expression ◽  
Human Skin ◽  
Healthy Human

The Role of Antimicrobial Peptides in Human Skin and in Skin Infectious Diseases

2008 ◽  
Vol 8 (3) ◽  
pp. 135-143 ◽  
Author(s):  
Birgit Schittek ◽  
Maren Paulmann ◽  
Ilknur Senyurek ◽  
Heiko Steffen
Keyword(s):  
Infectious Diseases ◽  
Antimicrobial Peptides ◽  
Human Skin

scholarly journals Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases

2017 ◽  
Vol 26 (11) ◽  
pp. 989-998 ◽  
Author(s):  
François Niyonsaba ◽  
Chanisa Kiatsurayanon ◽  
Panjit Chieosilapatham ◽  
Hideoki Ogawa
Keyword(s):  
Antimicrobial Peptides ◽  
Human Skin ◽  
Host Defense ◽  
Skin Diseases
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