scholarly journals Differential expression andin vivosecretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin

2013 ◽  
Vol 22 (5) ◽  
pp. 364-366 ◽  
Author(s):  
Maike Wittersheim ◽  
Jesko Cordes ◽  
Ulf Meyer-Hoffert ◽  
Jürgen Harder ◽  
Jürgen Hedderich ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Differential Expression ◽  
Human Skin ◽  
Healthy Human

scholarly journals Neurogenic Inflammation in Human and Rodent Skin

Physiology ◽  
2001 ◽  
Vol 16 (1) ◽  
pp. 33-37 ◽  
Author(s):  
M. Schmelz ◽  
L. J. Petersen
Keyword(s):  
Mast Cells ◽  
Human Skin ◽  
Neurogenic Inflammation ◽  
Healthy Human ◽  
Protein Extravasation

The combination of vasodilation and protein extravasation following activation of nociceptors has been termed “neurogenic inflammation.” In contrast to rodents, no neurogenic protein extravasation can be elicited in healthy human skin. Dermal microdialysis has considerably increased our knowledge about neurogenic inflammation in human skin, including the involvement of mast cells.

scholarly journals Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Richard S. Ahn ◽  
Keyon Taravati ◽  
Kevin Lai ◽  
Kristina M. Lee ◽  
Joanne Nititham ◽  
...  
Keyword(s):  
Human Skin ◽  
Immune Cell ◽  
Cell Populations ◽  
Healthy Human ◽  
Transcriptional Landscape

scholarly journals Individual cell motion in healthy human skin microvasculature by reflectance confocal video microscopy

2020 ◽  
Vol 27 (6) ◽  
Author(s):  
Inga Saknite ◽  
Zijun Zhao ◽  
J. Randall Patrinely ◽  
Michael Byrne ◽  
Madan Jagasia ◽  
...  
Keyword(s):  
Human Skin ◽  
Individual Cell ◽  
Video Microscopy ◽  
Healthy Human ◽  
Cell Motion

scholarly journals Genome Sequence of Staphylococcus massiliensis Strain S46, Isolated from the Surface of Healthy Human Skin

2013 ◽  
Vol 1 (4) ◽  
Author(s):  
R. Srivastav ◽  
A. Singh ◽  
P. K. Jangir ◽  
C. Kumari ◽  
S. Muduli ◽  
...  
Keyword(s):  
Human Skin ◽  
Genome Sequence ◽  
Healthy Human

scholarly journals 243 Permeability and immune barrier differences of healthy human skin

2019 ◽  
Vol 139 (9) ◽  
pp. S256
Author(s):  
O. Somogyi ◽  
B. Medgyesi ◽  
A. Jenei ◽  
Z. Dajnoki ◽  
K. Gáspár ◽  
...  
Keyword(s):  
Human Skin ◽  
Healthy Human

scholarly journals Tape stripping method is useful for the quantification of antimicrobial peptides on the human skin surface including the stratum corneum

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shigeyuki Ono ◽  
Nobuhiko Eda ◽  
Takuya Mori ◽  
Atsuko Otsuka ◽  
Nobuhiro Nakamura ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Stratum Corneum ◽  
Human Skin ◽  
Significant Positive Correlation ◽  
Skin Surface ◽  
Tape Stripping ◽  
Established Method ◽  
Positive Correlation ◽  
Physiological Importance ◽  
Stripping Method

Abstract Antimicrobial peptides (AMPs) play an important role in innate immunity in human skin. It is known that AMPs mainly function in the stratum corneum. Therefore, AMP concentrations in the stratum corneum need to be precisely measured to clarify functional and physiological importance of AMPs in cutaneous defence. Tape stripping (TS) is a well-established method by which components in the stratum corneum can be collected. However, the usefulness of the TS method for measuring AMP concentration in human skin remains unclear. Therefore, we compared it with another popular method, skin rinsing, which had been established as a method for measuring AMP concentration in human skin. When investigated on healthy medial forearm using RNase 7, which is one of the typical AMPs, as an index, there was a significant positive correlation between RNase 7 concentrations measured by the TS method at adjacent forearm sites, demonstrating the reproducibility of the TS method. Next, a significant positive correlation was detected in RNase 7 concentrations measured using the TS and the skin rinsing method, indicating that the TS method is comparable to the skin rinsing method. Thus, we speculate that the TS method is useful for measuring AMP concentration in human skin.

scholarly journals Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy

2018 ◽  
Vol 98 (2) ◽  
pp. 256-261 ◽  
Author(s):  
M Brandwein ◽  
G Fuks ◽  
A Israel ◽  
A Al-Ashhab ◽  
D Nejman ◽  
...  
Keyword(s):  
Human Skin ◽  
Temporal Stability ◽  
Dead Sea ◽  
Skin Microbiome ◽  
Healthy Human

scholarly journals Comprehensive analysis of MHC‐II expression in healthy human skin

2007 ◽  
Vol 85 (5) ◽  
pp. 363-369 ◽  
Author(s):  
Catherine E Angel ◽  
Elizabeth George ◽  
Lena L Ostrovsky ◽  
P Rod Dunbar
Keyword(s):  
Human Skin ◽  
Comprehensive Analysis ◽  
Healthy Human ◽  
Mhc Ii

The influence of luteolin on expression of epithelial MUC1 mucin in human skin fibroblasts

2016 ◽  
Vol 6 (2) ◽  
pp. 64-69
Author(s):  
J. Wosek ◽  
I. Radziejewska ◽  
E. Andrulewicz
Keyword(s):  
Human Skin ◽  
Real Time Pcr ◽  
Skin Fibroblasts ◽  
Pcr Analysis ◽  
Fibroblast Cells ◽  
Human Skin Fibroblasts ◽  
Healthy Human ◽  
Relative Level ◽  
Muc1 Mucin ◽  
Luteolin Treatment

Purpose: The membrane-anchored MUC1 mucin is typically expressed on normal and cancerous epithelial cells. Non-epithelial localization of this mucin is rare. However, the presence of MUC1 in human skin fibroblasts has been recently unexpectedly revealed. The aim of the study was to prove the expression of MUC1 mucin in human skin fibroblasts and the examine of the influence of luteolin on its expression. Materials and methods: ELISA tests and real-time PCR analysis were used to assess the expression of MUC1 mucin in fibroblast cells cocultured with 30 μM concentration of luteolin. Results: The expression of MUC1 was revealed in human skin fibroblasts. Luteolin decreased the relative level of mucin in cell lysates and media. Statistically significant decreased expression of MUC1 gene after luteolin treatment of fibroblasts cells was also revealed. Conclusion: Our results prove non-epithelial localization of MUC1 mucin. Luteolin inhibits the expression of MUC1 mucin in healthy human skin fibroblasts.

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