Feasibility of Hepatocyte Transplantation-Based Therapies for Primary Hyperoxalurias

2005 ◽  
Vol 25 (2) ◽  
pp. 161-170 ◽  
Author(s):  
Chandan Guha ◽  
Kosho Yamanouchi ◽  
Jinlan Jiang ◽  
Xia Wang ◽  
Namita Roy Chowdhury ◽  
...  
Keyword(s):  
Hepatocyte Transplantation ◽  
Primary Hyperoxalurias

Hepatocyte Transplantation: Regenerative Potential and Limitations

2014 ◽  
Vol 92 (2) ◽  
pp. 143-144
Author(s):  
Javier A.-Cienfuegos ◽  
Fernando Rotellar ◽  
Víctor Valentí ◽  
Fernando Pardo
Keyword(s):  
Hepatocyte Transplantation

The Primary Hyperoxalurias: An Algorithm for Diagnosis

2005 ◽  
Vol 25 (2) ◽  
pp. 154-160 ◽  
Author(s):  
Dawn S. Milliner
Keyword(s):  
Primary Hyperoxalurias

Percutaneous intrahepatic hepatocyte transplantation with fluoroscopic guidance

1998 ◽  
Vol 114 ◽  
pp. A1235
Author(s):  
V. Dixit ◽  
P. Dong ◽  
M. Arthur ◽  
J. Roberts ◽  
P. Martin ◽  
...  
Keyword(s):  
Hepatocyte Transplantation ◽  
Fluoroscopic Guidance

HEPATOCYTE TRANSPLANTATION THROUGH THE HEPATIC VEIN: A NEW ROUTE OF CELL TRANSPLANTATION TO THE LIVER

2010 ◽  
Vol 90 ◽  
pp. 1042
Author(s):  
Y. Goto ◽  
K. Ohashi ◽  
R. Utoh ◽  
M. Yamamoto ◽  
T. Okano
Keyword(s):  
Cell Transplantation ◽  
Hepatic Vein ◽  
Hepatocyte Transplantation

scholarly journals Regional Transient Portal Ischemia and Irradiation as Preparative Regimen for Hepatocyte Transplantation

2011 ◽  
Vol 20 (2) ◽  
pp. 303-312 ◽  
Author(s):  
S. Koenig ◽  
Q. Yuan ◽  
P. Krause ◽  
H. Christiansen ◽  
M. Rave-Fraenk ◽  
...  
Keyword(s):  
Hepatocyte Transplantation ◽  
Preparative Regimen

Significant Improvement of Survival by Intrasplenic Hepatocyte Transplantation in Totally Hepatectomized Rats

1996 ◽  
Vol 5 (3) ◽  
pp. 369-378 ◽  
Author(s):  
Birgit A.P.M. Vogels ◽  
Martinus A.W. Maas ◽  
Anne Bosma ◽  
Robert A.F.M. Chamuleau
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Survival Time ◽  
Histological Examination ◽  
Hepatocyte Transplantation ◽  
Shunt Operation ◽  
Blood Ammonia ◽  
Liver Atrophy ◽  
Arterial Blood ◽  
Clinical Grading

The effect of intrasplenic hepatocyte transplantation (HTX) was studied in an experimental model of acute liver failure in rats with chronic liver atrophy. Rats underwent a portacaval shunt operation on Day -14 to induce liver atrophy, and underwent total hepatectomy on Day 0 as a start of acute liver failure. Intrasplenic hepatocyte or sham transplantation was performed on Day -7, -3, or -1 (n = 4 to 6 per group). During the period following hepatectomy, mean arterial blood pressure was maintained above 80 mm Hg and hypoglycaemia was prevented. Severity of hepatic encephalopathy was assessed by clinical grading and EEG spectral analysis, together with determination of blood ammonia and plasma amino acid concentrations, and “survival” time. Histological examination of the spleen and lungs was performed after sacrifice. Intrasplenic hepatocyte transplantation resulted in a significant improvement in clinical grading in all transplanted groups (p < 0.05), whereas a significant improvement in EEG left index was seen only in the group with transplantation on Day -1 (p < 0.05). In contrast to hepatocyte transplantation 1 day before total hepatectomy, rats with hepatocyte transplantation 3 and 7 days before total hepatectomy showed a significant 3- and 2-fold increase in “survival” time compared to sham transplanted controls: HTX at Day -1: 7.5 ± 0.3 h vs. 5.9 ± 0.6 h (p > 0.05), HTX at Day -3:19.7 ± 3.7 h vs. 6.5 ± 0.3 h (p < 0.05), and HTX at Day -7: 13.8 ± 3.2 h vs. 6.3 ± 0.3 h (p < 0.05). Furthermore, rats with hepatocyte transplantation on Day -3 and -7 showed significantly lower blood ammonia concentrations after total hepatectomy (p < 0.0001). Histological examination of the spleens after sacrifice showed clusters of hepatocytes in the red pulp. Hepatocytes present in the spleen for 3 and 7 days showed bile accumulation and spots of beginning necrosis. The present data show that in a hard model of complete liver failure in portacaval shunted rats, intrasplenic hepatocyte transplantation is able to prolong “survival” time significantly 2- to 3-fold. The relevance of this observation for human application is discussed.

Therapeutic potential of hepatocyte transplantation

2002 ◽  
Vol 13 (6) ◽  
pp. 439-446 ◽  
Author(s):  
Sanjeev Gupta ◽  
Jayanta Roy Chowdhury
Keyword(s):  
Therapeutic Potential ◽  
Hepatocyte Transplantation

scholarly journals Hepatocyte Transplantation

1999 ◽  
Vol 12 (6) ◽  
pp. 471-472 ◽  
Author(s):  
Michio Mito ◽  
Masayuki Sawa
Keyword(s):  
Hepatocyte Transplantation
Sign in / Sign up

Export Citation Format

Share Document