Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells

10.1038/73179 ◽  
2000 ◽  
Vol 6 (3) ◽  
pp. 320-326 ◽  
Author(s):  
Kristin M. Braun ◽  
Jay L. Degen ◽  
Eric P. Sandgren
Keyword(s):  
Liver Disease ◽  
Therapeutic Effect ◽  
Hepatocyte Transplantation ◽  
Donor Cells

Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats

Phytomedicine ◽  
2021 ◽  
Vol 85 ◽  
pp. 153550
Author(s):  
Qiao-Ping Li ◽  
Yao-Xing Dou ◽  
Zi-Wei Huang ◽  
Han-Bin Chen ◽  
Yu-Cui Li ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Therapeutic Effect ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Therapeutic Effect of Puerarin on Non-Alcoholic Rat Fatty Liver by Improving Leptin Signal Transduction through JAK2/STAT3 Pathways

2009 ◽  
Vol 37 (01) ◽  
pp. 69-83 ◽  
Author(s):  
Peiyong Zheng ◽  
Guang Ji ◽  
Zansong Ma ◽  
Tao Liu ◽  
Lianjun Xin ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Liver Disease ◽  
Fatty Liver ◽  
Therapeutic Effect ◽  
Fatty Liver Disease ◽  
Receptor Expression ◽  
Male Rat ◽  
Group Model ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

In order to investigate the mechanism of the therapeutic effect of puerarin on non-alcoholic fatty liver disease, a non-alcoholic fatty disease male rat model was induced by a high fat diet, all rats were randomly divided into a blank group, model group, simavastatin group and puerarin group. After 4 weeks of drug treatment, the liver was slided to investigate pathological morphology. Elisa was used to measure the total cholesterol (TC), triglyeride (TG) in liver, and leptin content in serum. RT-PCR and Western blotting were employed to detect liver leptin mRNA receptor expression and P-JAK2, P-STAT3 expression levels in the liver respectively. The results showed that puerarin significantly decreased the TG, TC content in liver of the non-alcoholic fatty disease rats, ameliorated steatosis in liver, lowered liver inflammatory reaction, decreased leptin level in serum, and enhanced the expression of leptin receptor mRNA and P-JAK2/P-STAT3 level. All the results demonstrated that puerarin can exhibit therapeutic effect on non-alcoholic fatty liver disease by improving leptin signal transduction through JAK2/STAT3 pathways.

Empagliflozin Exhibits Therapeutic Effect in Preclinical Model of Liver Disease (NASH)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1228-P
Author(s):  
ERIC MAYOUX ◽  
THOMAS KLEIN ◽  
MICHAEL MARK
Keyword(s):  
Liver Disease ◽  
Therapeutic Effect ◽  
Preclinical Model

scholarly journals Human hepatocyte transplantation for liver disease: current status and future perspectives

2017 ◽  
Vol 83 (1-2) ◽  
pp. 232-240 ◽  
Author(s):  
V Iansante ◽  
R R Mitry ◽  
C Filippi ◽  
E Fitzpatrick ◽  
A Dhawan
Keyword(s):  
Liver Disease ◽  
Human Hepatocyte ◽  
Hepatocyte Transplantation ◽  
Current Status ◽  
Future Perspectives

scholarly journals Hepatic Tissue Environment in NEMO-Deficient Mice Critically Regulates Positive Selection of Donor Cells after Hepatocyte Transplantation

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100786 ◽  
Author(s):  
Michaela Kaldenbach ◽  
Francisco Javier Cubero ◽  
Stephanie Erschfeld ◽  
Christian Liedtke ◽  
Christian Trautwein ◽  
...  
Keyword(s):  
Positive Selection ◽  
Hepatocyte Transplantation ◽  
Hepatic Tissue ◽  
Donor Cells ◽  
Deficient Mice ◽  
Selection Of
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