scholarly journals Coagulation and Fibrinolysis Parameters in Type 2 Diabetic Patients with and without Diabetic Vascular Complications

2004 ◽  
Vol 14 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Cihangir Erem ◽  
Arif Hacıhasanoğlu ◽  
Şükrü Çelik ◽  
Ercüment Ovalı ◽  
H. Önder Ersöz ◽  
...  
Keyword(s):  
Vascular Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diabetic Vascular Complications ◽  
Type 2 Diabetic ◽  
Coagulation And Fibrinolysis

scholarly journals Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity

2013 ◽  
Vol 12 (1) ◽  
pp. 88 ◽  
Author(s):  
Hirofumi Nagao ◽  
Susumu Kashine ◽  
Hitoshi Nishizawa ◽  
Takuya Okada ◽  
Takekazu Kimura ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Abdominal Obesity ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Increased Fibrinogen Production in Type 2 Diabetic Patients without Detectable Vascular Complications: Correlation with Plasma Glucagon Concentrations

2000 ◽  
Vol 85 (9) ◽  
pp. 3121-3125 ◽  
Author(s):  
R. Barazzoni ◽  
M. Zanetti ◽  
G. Davanzo ◽  
E. Kiwanuka ◽  
P. Carraro ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Concentrations ◽  
Vascular Complications ◽  
Macrovascular Complications ◽  
Diabetic Patients ◽  
Fibrinogen Concentration ◽  
Plasma Glucagon ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract Fibrinogen is a strong cardiovascular risk factor in the general population, and increased fibrinogen plasma concentrations have been reported in type 2 diabetic patients. However, the mechanisms leading to hyperfibrinogenemia in type 2 diabetes are not known. It is also not known whether possible alterations of fibrinogen turnover may precede clinical diabetic micro- and macrovascular complications and therefore potentially contribute to their onset. To address these questions, fibrinogen production was determined in six male type 2 diabetic patients without detectable micro- and macrovascular complications (age, 45 ± 4 yr; body mass index, 27 ± 0.9 kg/m2) and in seven nondiabetic matched controls using leucine isotope precursor-product relationships. Plasma glucose (P < 0.001), insulin (P < 0.05), and glucagon concentrations (P < 0.01) were increased in the patients. Diabetic patients also had increased plasma fibrinogen concentration (+∼50%; P < 0.01) and pool (+∼40%; P < 0.01) as well as fractional (+∼35%; P = 0.08) and absolute (+∼100%; P < 0.01) synthetic rates. The plasma glucagon concentration was positively related (P < 0.005 or less) to the fibrinogen concentration as well as to fractional and absolute synthetic rates. Thus, fibrinogen production is markedly enhanced, and this alteration is likely to determine the observed hyperfibrinogenemia in type 2 diabetic patients. Hyperglucagonemia may contribute to the increased fibrinogen production. These findings in normoalbuminuric patients without clinical complications support the hypothesis that increased fibrinogen production and plasma concentrations may precede and possibly contribute to the onset of clinical cardiovascular complications in type 2 diabetes.

scholarly journals The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Zhu Li ◽  
Gang Wang ◽  
Yan-juan Zhu ◽  
Chen-guang Li ◽  
Yun-zhao Tang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type 2 Diabetic Patients ◽  
Glycation End Products ◽  
The Relationship ◽  
Type 2 Diabetic ◽  
Diabetes Patients

Advanced glycation end-products (AGEs), measured by skin autofluorescence (AF), are a factor in the development or worsening of many degenerative diseases, such as diabetes and atherosclerosis. Irisin levels have been associated with diabetes, endothelial dysfunction and atherosclerosis. The objective of the present study was to investigate whether circulating irisin levels are correlated with skin AF values in type 2 diabetes patients. A total of 362 Chinese type 2 diabetic patients and 100 age- and sex-matched healthy controls were recruited in the present study. Clinical characteristics, blood biochemistry and circulating irisin levels were measured. Skin AF was measured using an AGE reader. Circulating irisin levels were significantly lower, while skin AF values were increased in type 2 diabetes compared with controls (P<0.05 respectively). By dividing the distribution of skin AF values into tertiles, serum irisin levels gradually lowered with increasing skin AF values (P<0.05). After adjusting for covariates, multivariate stepwise regression analysis demonstrated that serum lower irisin levels were independently associated with skin AF (P=0.009). Circulating irisin levels were lower in type 2 diabetes patients compared with healthy controls. Lower levels of irisin are independently associated with elevated skin AF values, indicating that circulating irisin levels could be associated with AGEs accumulation, which is one of the reasons causing vascular complications in diabetic patients.

scholarly journals Genes for systemic vascular complications are differentially expressed in the livers of Type 2 diabetic patients

Diabetologia ◽  
2004 ◽  
Vol 47 (4) ◽  
pp. 638-647 ◽  
Author(s):  
T. Takamura ◽  
M. Sakurai ◽  
T. Ota ◽  
H. Ando ◽  
S. Kaneko ◽  
...  
Keyword(s):  
Vascular Complications ◽  
Differentially Expressed ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Prevalence of metabolic syndrome in Japanese type 2 diabetic patients and its significance for chronic vascular complications

2008 ◽  
Vol 79 (2) ◽  
pp. 310-317 ◽  
Author(s):  
Yoshinori Shimajiri ◽  
Keiko Tsunoda ◽  
Machi Furuta ◽  
Yoshiki Kadoya ◽  
Shyoichi Yamada ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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