Lung Cancer Incidence in the Czech Republic: A Time-Trend Study

2004 ◽  
Vol 27 (4) ◽  
pp. 376-379 ◽  
Author(s):  
V. Janout ◽  
P. Siroky ◽  
J. Novak ◽  
L. Cizek ◽  
H. Koukalova ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Czech Republic ◽  
Cancer Incidence ◽  
Time Trend ◽  
Lung Cancer Incidence ◽  
The Czech Republic ◽  
Trend Study

scholarly journals Mortality and cancer incidence among underground uranium miners in the Czech Republic 1977–1992

2019 ◽  
Vol 76 (8) ◽  
pp. 511-518 ◽  
Author(s):  
Kaitlin Kelly-Reif ◽  
Dale P Sandler ◽  
David Shore ◽  
Mary Schubauer-Berigan ◽  
Melissa A Troester ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Czech Republic ◽  
Cancer Incidence ◽  
Years Of Life Lost ◽  
The Czech Republic ◽  
Cancer Subtypes ◽  
Uranium Miners ◽  
Risk Of Mortality ◽  
Mining Conditions ◽  
Standardised Mortality Ratios

ObjectivesUranium miners in Příbram, Czech Republic were exposed to low and moderate levels of radon gas and other hazards. It is unknown whether these hazards increase the risk of mortality or cancer incidence when compared with the general Czech population.MethodsA cohort of 16 434 male underground miners employed underground for at least 1 year between 1946 and 1976, and alive and residing in the Czech Republic in 1977, were followed for mortality and cancer incidence through 1992. We compared observed deaths and cancer incidence to expectation based on Czech rates. Standardised mortality ratios (SMRs), standardised incidence ratios (SIRs) and causal mortality ratios were calculated.ResultsUnderground workers in the Příbram mines had higher rates of death than expected due to all causes (SMR=1.23, 95% CI 1.20 to 1.27), all cancers (SMR=1.52, 95% CI 1.44 to 1.60), lung cancer (SMR=2.12, 95% CI 1.96 to 2.28) and extrathoracic cancer (SMR=1.41, 95% CI 1.15 to 1.77). Similar excess was observed in cancer incidence analyses, with the addition of stomach cancer (SIR=1.37, 95% CI 1.11 to 1.63), liver cancer (SIR=1.70, 95% CI 1.16 to 2.25) and rectal cancer (SIR=1.41, 95% CI 1.16 to 1.66). The SIR was elevated for all leukaemias (SIR=1.51, 95% CI 1.08 to 2.07) and for lymphatic and haematopoietic cancers combined (SIR=1.31, 95% CI 1.05 to 1.61), but results for specific subtypes were imprecise. Deaths due to hazardous mining conditions resulted in 0.33 person-years of life lost per miner.ConclusionsOccupational exposure to the Příbram mines resulted in excess cancers at several sites, including sites previously linked to radon and uranium exposure. Incidence analyses showed relative excess of several additional cancer subtypes.

scholarly journals Lung and extrathoracic cancer incidence among underground uranium miners exposed to radon progeny in the Příbram region of the Czech Republic: a case–cohort study

2021 ◽  
pp. oemed-2021-107392
Author(s):  
Kaitlin Kelly-Reif ◽  
Dale P Sandler ◽  
David Shore ◽  
Mary Schubauer-Berigan ◽  
Melissa Troester ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Czech Republic ◽  
Cancer Incidence ◽  
Relative Rate ◽  
Positive Association ◽  
The Czech Republic ◽  
Radon Exposure ◽  
Uranium Miners ◽  
Never Smokers

ObjectivesRadon is carcinogenic, but more studies are needed to understand relationships with lung cancer and extrathoracic cancers at low exposures. There are few studies evaluating associations with cancer incidence or assessing the modifying effects of smoking.MethodsWe conducted a case–cohort study with 16 434 underground uranium miners in the Czech Republic with cancer incidence follow-up 1977–1996. Associations between radon exposure and lung cancer, and extrathoracic cancer, were estimated with linear excess relative rate (ERR) models. We examined potential modifying effects of smoking, time since exposure and exposure rate.ResultsUnder a simple ERR model, assuming a 5-year exposure lag, the estimated ERR of lung cancer per 100 working level months (WLM) was 0.54 (95% CI 0.33 to 0.83) and the estimated ERR of extrathoracic cancer per 100 WLM was 0.07 (95% CI −0.17 to 0.72). Most lung cancer cases were observed among smokers (82%), and the estimated ERR of lung cancer per 100 WLM was larger among smokers (ERR/100 WLM=1.35; 95% CI 0.84 to 2.15) than among never smokers (ERR/100 WLM=0.12; 95% CI −0.05 to 0.49). Among smokers, the estimated ERR of lung cancer per 100 WLM decreased with time since exposure from 3.07 (95% CI −0.04 to 10.32) in the period 5–14 years after exposure to 1.05 (95% CI 0.49 to 1.87) in the period 25+ years after exposure.ConclusionsWe observed positive associations between cumulative radon exposure and lung cancer, consistent with prior studies. We observed a positive association between cumulative radon exposure and extrathoracic cancers, although the estimates were small. There was evidence that the association between radon and lung cancer was modified by smoking in a multiplicative or super-multiplicative fashion.

scholarly journals Multiple air pollutant exposure and lung cancer in Tehran, Iran

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zahra Khorrami ◽  
Mohsen Pourkhosravani ◽  
Maysam Rezapour ◽  
Koorosh Etemad ◽  
Seyed Mahmood Taghavi-Shahri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Air Pollution ◽  
Cancer Incidence ◽  
Latent Profile Analysis ◽  
Negative Binomial ◽  
Profile Analysis ◽  
Positive Association ◽  
Air Pollutant ◽  
World Health ◽  
Lung Cancer Incidence

AbstractLung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N = 1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR = 1.05, for each 10 unit increase in air pollutant), benzene (IRR = 3.86), toluene (IRR = 1.50), ethylbenzene (IRR = 5.16), p-xylene (IRR = 9.41), o-xylene (IRR = 7.93), m-xylene (IRR = 2.63) and TBTEX (IRR = 1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR = 1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.

Do socioeconomic factors modify the effects of PM1 and SO2 on lung cancer incidence in China?

2021 ◽  
Vol 756 ◽  
pp. 143998
Author(s):  
Huagui Guo ◽  
Jing Wei ◽  
Xin Li ◽  
Hung Chak Ho ◽  
Yimeng Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Socioeconomic Factors ◽  
Cancer Incidence ◽  
Lung Cancer Incidence

scholarly journals Spatial and Temporal Analysis of Lung Cancer in Shenzhen, 2008–2018

2020 ◽  
Vol 18 (1) ◽  
pp. 26
Author(s):  
Lin Lei ◽  
Anyan Huang ◽  
Weicong Cai ◽  
Ling Liang ◽  
Yirong Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Spatial Autocorrelation ◽  
Incidence Rate ◽  
Cancer Incidence ◽  
Southern China ◽  
Percentage Change ◽  
Spatial Autocorrelation Analysis ◽  
Lung Cancer Incidence ◽  
Annual Percentage Change ◽  
Autocorrelation Analysis

Lung cancer is the most commonly diagnosed cancer in China. The incidence trend and geographical distribution of lung cancer in southern China have not been reported. The present study explored the temporal trend and spatial distribution of lung cancer incidence in Shenzhen from 2008 to 2018. The lung cancer incidence data were obtained from the registered population in the Shenzhen Cancer Registry System between 2008 and 2018. The standardized incidence rates of lung cancer were analyzed by using the joinpoint regression model. The Moran’s I method was used for spatial autocorrelation analysis and to further draw a spatial cluster map in Shenzhen. From 2008 to 2018, the average crude incidence rate of lung cancer was 27.1 (1/100,000), with an annual percentage change of 2.7% (p < 0.05). The largest average proportion of histological type of lung cancer was determined as adenocarcinoma (69.1%), and an increasing trend was observed in females, with an average annual percentage change of 14.7%. The spatial autocorrelation analysis indicated some sites in Shenzhen as a high incidence rate spatial clustering area. Understanding the incidence patterns of lung cancer is useful for monitoring and prevention.

Cancer incidence trends in the Czech Republic

2021 ◽  
Vol 74 ◽  
pp. 101975
Author(s):  
Lucie Pehalova ◽  
Denisa Krejci ◽  
Lenka Snajdrova ◽  
Ladislav Dusek
Keyword(s):  
Czech Republic ◽  
Cancer Incidence ◽  
The Czech Republic ◽  
Incidence Trends
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