LUNG CANCER INCIDENCE AND CANCER RISK FROM RADIOACTIVITY – SOME DATA FOR THE CAPITAL OF MONTENEGRO

2020 ◽  
Author(s):  
Danko Živković ◽  
Nevenka M. Antović
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Lung Cancer Incidence

scholarly journals Metformin Use and Lung Cancer Risk in Diabetic Patients: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Long Yao ◽  
Mengke Liu ◽  
Yunlong Huang ◽  
Kaiming Wu ◽  
Xin Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Cancer Incidence ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
Lung Cancer Incidence ◽  
Lower Lung ◽  
The Relationship

Background. Antidiabetic medications (ADMs) can alter the risk of different types of cancer, but the relationship between lung cancer incidence and metformin remains controversial. Our aim was to quantitatively estimate the relationship between incidences of lung cancer and metformin in patients with diabetes in this meta-analysis. Methods. We performed a search in PubMed, Embase, ISI Web of Science, and Cochrane Library until September 20, 2017. The odds ratio (OR), relative risk (RR) or hazard ratio (HR), and 95% confidence interval (95% CI) were estimated using the random-effect model. The Newcastle-Ottawa Scale (NOS) was used to assess the study quality. Results. A total of 13 studies (10 cohort studies and 3 case-control studies) were included in the meta-analysis. Compared to nonmetformin users, metformin probably decreased lung cancer incidence in diabetic patients (RR=0.89; 95% CI, 0.83-0.96; P=0.002) with significant heterogeneity (Q=35.47, I2=66%, P=0.0004). Subgroup analysis showed that cohort studies (RR=0.91; 95% CI, 0.85-0.98; P=0.008), location in Europe (RR=0.90; 95% CI, 0.86-0.94; P<0.0001), the control drug of the sulfonylurea group (RR=0.91; 95% CI, 0.86-0.96; P=0.001), and adjusting for smoking (RR=0.86; 95% CI, 0.75-1.00; P=0.05) may be related to lower lung cancer risk. No significant publication bias was detected using a funnel plot. Conclusion. Metformin use was related to a lower lung cancer risk in diabetic patients compared to nonusers, but this result was retrieved from observational studies and our findings need more well-designed RCTs to confirm the association.

Active and passive smoking in relation to lung cancer incidence in the Women's Health Initiative prospective cohort study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1504-1504
Author(s):  
Ange Wang ◽  
Jessica Kubo ◽  
Juhua Luo ◽  
Manisha Desai ◽  
Michael T Henderson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Passive Smoking ◽  
Prospective Cohort ◽  
Lung Cancer Risk ◽  
Lung Cancer Incidence ◽  
Cancer Subtypes ◽  
Former Smokers ◽  
Never Smokers

1504 Background: The relationship between both active and passive smoking and lung cancer incidence in post-menopausal women was examined in theWomen’s Health Initiative Observational Study (WHI-OS). Methods: The WHI-OS, a prospective cohort study conducted at 40 U.S. centers, enrolled women ages 50-79 from 1993-1998.Among 93,676 participants, 76,304 women with complete smoking and covariate data comprised the analytic cohort, in which the association of lung cancer incidence with active and passive (childhood, adult home, and work) smoking exposure was studied. Results: Over 10.5 meanyears of follow-up with 901 lung cancer cases, lung cancer incidence was higher in current smokers (HR 13.44, 95% CI 10.80-16.75) and former smokers (HR 4.20, 95% CI 3.48-5.08), compared to never smokers. This relationship was dose-dependent for both current and former smokers. Risk of all lung cancer subtypes, particularly small cell lung cancer (SCLC) and squamous cell carcinoma (SqCC), was higher in smokers. Among never smokers, any passive smoking exposure (HR 0.88, 95% CI 0.52-1.49) and most passive smoking categories did not significantly increase lung cancer risk, compared to no passive exposure; however, passive exposure as an adult at home for >=30 years was associated with increased risk, of borderline significance (HR 1.61, 95% CI 1.00-2.58). Current smokers had an annualized lung cancer incidence rate of 472.9 cases/100,000 person-years, compared to 158.1 for former smokers and 36.2 for never smokers (112.3 overall). Conclusions: To our knowledge, this is the first study to examine both active and passive smoking in relation to lung cancer incidence in a complete prospective cohort of U.S. women. Active smoking is associated with significant increases in incidence of all lung cancer subtypes in post-menopausal women, particularly SCLC and SqCC. Smoking cessation decreases lung cancer risk. Prolonged exposure as an adult at home may be the strongest passive smoking contributor to lung cancer risk in this cohort. The findings support continued need for investment in smoking prevention and cessation, research on passive smoking, and understanding of lung cancer risk factors other than smoking.

scholarly journals Associations between Biomarkers of Exposure and Lung Cancer Risk among Exclusive Cigarette Smokers in the Golestan Cohort Study

2021 ◽  
Vol 18 (14) ◽  
pp. 7349
Author(s):  
Brian L. Rostron ◽  
Jia Wang ◽  
Arash Etemadi ◽  
Sapna Thakur ◽  
Joanne T. Chang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Lung Cancer Risk ◽  
Disease Risk ◽  
Geometric Mean ◽  
Lung Cancer Incidence ◽  
Cigarette Smokers ◽  
Opium Use

Biomarkers of tobacco exposure are known to be associated with disease risk but previous studies are limited in number and restricted to certain regions. We conducted a nested case–control study examining baseline levels and subsequent lung cancer incidence among current male exclusive cigarette smokers in the Golestan Cohort Study in Iran. We calculated geometric mean biomarker concentrations for 28 matched cases and 52 controls for the correlation of biomarker levels among controls and for adjusted odds’ ratios (ORs) for lung cancer incidence by biomarker concentration, accounting for demographic characteristics, smoking quantity and duration, and opium use. Lung cancer cases had higher average levels of most biomarkers including total nicotine equivalents (TNE-2), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and 3-hydroxyfluorene (3-FLU). Many biomarkers correlated highly with one another including TNE-2 with NNAL and N-Acetyl-S-(2-cyanoethyl)-L-cysteine (2CYEMA), and N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine (t4HBEMA) with N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine (3HMPMA) and N-Acetyl-S-(4-hydroxy-2-methyl-2-buten-1-yl)-L-cysteine (4HMBEMA). Lung cancer risk increased with concentration for several biomarkers, including TNE-2 (OR = 2.22, 95% CI = 1.03, 4.78) and NNN (OR = 2.44, 95% CI = 1.13, 5.27), and estimates were significant after further adjustment for demographic and smoking characteristics for 2CYEMA (OR = 2.17, 95% CI = 1.03, 4.55), N-Acetyl-S-(2-carbamoylethyl)-L-cysteine (2CAEMA) (OR = 2.14, 95% CI = 1.01, 4.55), and N-Acetyl-S-(2-hydroxypropyl)-L-cysteine (2HPMA) (OR = 2.85, 95% CI = 1.04, 7.81). Estimates were not significant with adjustment for opium use. Concentrations of many biomarkers were higher at the baseline for participants who subsequently developed lung cancer than among the matched controls. Odds of lung cancer were higher for several biomarkers including with adjustment for smoking exposure for some but not with adjustment for opium use.

scholarly journals Multiple air pollutant exposure and lung cancer in Tehran, Iran

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zahra Khorrami ◽  
Mohsen Pourkhosravani ◽  
Maysam Rezapour ◽  
Koorosh Etemad ◽  
Seyed Mahmood Taghavi-Shahri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Air Pollution ◽  
Cancer Incidence ◽  
Latent Profile Analysis ◽  
Negative Binomial ◽  
Profile Analysis ◽  
Positive Association ◽  
Air Pollutant ◽  
World Health ◽  
Lung Cancer Incidence

AbstractLung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N = 1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR = 1.05, for each 10 unit increase in air pollutant), benzene (IRR = 3.86), toluene (IRR = 1.50), ethylbenzene (IRR = 5.16), p-xylene (IRR = 9.41), o-xylene (IRR = 7.93), m-xylene (IRR = 2.63) and TBTEX (IRR = 1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR = 1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.

Do socioeconomic factors modify the effects of PM1 and SO2 on lung cancer incidence in China?

2021 ◽  
Vol 756 ◽  
pp. 143998
Author(s):  
Huagui Guo ◽  
Jing Wei ◽  
Xin Li ◽  
Hung Chak Ho ◽  
Yimeng Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Socioeconomic Factors ◽  
Cancer Incidence ◽  
Lung Cancer Incidence

scholarly journals Spatial and Temporal Analysis of Lung Cancer in Shenzhen, 2008–2018

2020 ◽  
Vol 18 (1) ◽  
pp. 26
Author(s):  
Lin Lei ◽  
Anyan Huang ◽  
Weicong Cai ◽  
Ling Liang ◽  
Yirong Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Spatial Autocorrelation ◽  
Incidence Rate ◽  
Cancer Incidence ◽  
Southern China ◽  
Percentage Change ◽  
Spatial Autocorrelation Analysis ◽  
Lung Cancer Incidence ◽  
Annual Percentage Change ◽  
Autocorrelation Analysis

Lung cancer is the most commonly diagnosed cancer in China. The incidence trend and geographical distribution of lung cancer in southern China have not been reported. The present study explored the temporal trend and spatial distribution of lung cancer incidence in Shenzhen from 2008 to 2018. The lung cancer incidence data were obtained from the registered population in the Shenzhen Cancer Registry System between 2008 and 2018. The standardized incidence rates of lung cancer were analyzed by using the joinpoint regression model. The Moran’s I method was used for spatial autocorrelation analysis and to further draw a spatial cluster map in Shenzhen. From 2008 to 2018, the average crude incidence rate of lung cancer was 27.1 (1/100,000), with an annual percentage change of 2.7% (p < 0.05). The largest average proportion of histological type of lung cancer was determined as adenocarcinoma (69.1%), and an increasing trend was observed in females, with an average annual percentage change of 14.7%. The spatial autocorrelation analysis indicated some sites in Shenzhen as a high incidence rate spatial clustering area. Understanding the incidence patterns of lung cancer is useful for monitoring and prevention.

Contrasting temporal trends in lung cancer incidence by socioeconomic status among women in New South Wales, Australia, 1985–2009

Lung Cancer ◽  
2017 ◽  
Vol 108 ◽  
pp. 55-61 ◽  
Author(s):  
Xue Qin Yu ◽  
Qingwei Luo ◽  
Clare Kahn ◽  
Paul Grogan ◽  
Dianne L. O’Connell ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Socioeconomic Status ◽  
Cancer Incidence ◽  
New South ◽  
New South Wales ◽  
Temporal Trends ◽  
Lung Cancer Incidence ◽  
South Wales
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