Nicotinic Receptor Stimulation Blocks Neurotoxicity Induced by Amyloid-β via the Phosphatidylinositol-3-Kinase Cascade

2004 ◽  
pp. 108-122
Author(s):  
T. Kihara ◽  
S. Shimohama
Keyword(s):  
Amyloid Beta ◽  
Nicotinic Receptor ◽  
Phosphatidylinositol 3 Kinase ◽  
Receptor Stimulation ◽  
Kinase Cascade ◽  
Phosphatidylinositol 3

Effects of chronic treatment with donepezil via α7-nicotinic receptor and phosphatidylinositol 3-kinase cascade

2007 ◽  
Vol 58 ◽  
pp. S117
Author(s):  
Yuki Takada-Takatori ◽  
Toshiaki Kume ◽  
Yuta Ohgi ◽  
Tetsuhiro Niidome ◽  
Takeshi Fujii ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Chronic Treatment ◽  
Phosphatidylinositol 3 Kinase ◽  
Kinase Cascade ◽  
Phosphatidylinositol 3

scholarly journals Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade

2002 ◽  
Vol 70 (3) ◽  
pp. 274-282 ◽  
Author(s):  
Takeshi Kihara ◽  
Shun Shimohama ◽  
Hideyuki Sawada ◽  
Kazuhiro Honda ◽  
Tomoki Nakamizo ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cortical Neurons ◽  
Phosphatidylinositol 3 Kinase ◽  
Dopamine D2 ◽  
Kinase Cascade ◽  
Phosphatidylinositol 3

scholarly journals The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

2010 ◽  
Vol 191 (4) ◽  
pp. 827-843 ◽  
Author(s):  
Zhixun Dou ◽  
Mohar Chattopadhyay ◽  
Ji-An Pan ◽  
Jennifer L. Guerriero ◽  
Ya-Ping Jiang ◽  
...  
Keyword(s):  
Catalytic Subunit ◽  
Regulatory Subunit ◽  
Cell Renewal ◽  
Phosphatidylinositol 3 Kinase ◽  
Positive Regulator ◽  
Evolutionarily Conserved ◽  
Kinase Cascade ◽  
Tor Kinase ◽  
Multicellular Organisms ◽  
Phosphatidylinositol 3

Autophagy is an evolutionarily conserved cell renewal process that depends on phosphatidylinositol 3-phosphate (PtdIns(3)P). In metazoans, autophagy is inhibited by PtdIns(3,4,5)P3, the product of class IA PI3Ks, which mediates the activation of the Akt–TOR kinase cascade. However, the precise function of class IA PI3Ks in autophagy remains undetermined. Class IA PI3Ks are heterodimeric proteins consisting of an 85-kD regulatory subunit and a 110-kD catalytic subunit. Here we show that the class IA p110-β catalytic subunit is a positive regulator of autophagy. Genetic deletion of p110-β results in impaired autophagy in mouse embryonic fibroblasts, liver, and heart. p110-β does not promote autophagy by affecting the Akt–TOR pathway. Rather, it associates with the autophagy-promoting Vps34–Vps15–Beclin 1–Atg14L complex and facilitates the generation of cellular PtdIns(3)P. Our results unveil a previously unknown function for p110-β as a positive regulator of autophagy in multicellular organisms.

Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity

Toxicology ◽  
2008 ◽  
Vol 243 (1-2) ◽  
pp. 43-50 ◽  
Author(s):  
Kyu-Yong Lee ◽  
Seong-Ho Koh ◽  
Min Young Noh ◽  
Seung Hyun Kim ◽  
Young Joo Lee
Keyword(s):  
Amyloid Beta ◽  
Phosphatidylinositol 3 Kinase ◽  
Kinase Activation ◽  
Phosphatidylinositol 3
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