scholarly journals Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade

2002 ◽  
Vol 70 (3) ◽  
pp. 274-282 ◽  
Author(s):  
Takeshi Kihara ◽  
Shun Shimohama ◽  
Hideyuki Sawada ◽  
Kazuhiro Honda ◽  
Tomoki Nakamizo ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cortical Neurons ◽  
Phosphatidylinositol 3 Kinase ◽  
Dopamine D2 ◽  
Kinase Cascade ◽  
Phosphatidylinositol 3

scholarly journals Reelin Signals through Phosphatidylinositol 3-Kinase and Akt To Control Cortical Development and through mTor To Regulate Dendritic Growth

2007 ◽  
Vol 27 (20) ◽  
pp. 7113-7124 ◽  
Author(s):  
Yves Jossin ◽  
André M. Goffinet
Keyword(s):  
Cortical Neurons ◽  
Hippocampal Neurons ◽  
Matrix Protein ◽  
Glycogen Synthase ◽  
Extracellular Matrix Protein ◽  
Cortical Plate ◽  
Target Cells ◽  
Neuronal Cultures ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

ABSTRACT Reelin is an extracellular matrix protein with various functions during development and in the mature brain. It activates different signaling cascades in target cells, one of which is the phosphatidylinositol 3-kinase (PI3K) pathway, which we investigated further using pathway inhibitors and in vitro brain slice and neuronal cultures. We show that the mTor (mammalian target of rapamycin)-S6K1 (S6 kinase 1) pathway is activated by Reelin and that this depends on Dab1 (Disabled-1) phosphorylation and activation of PI3K and Akt (protein kinase B). PI3K and Akt are required for the effects of Reelin on the organization of the cortical plate, but their downstream partners mTor and glycogen synthase kinase 3β (GSK3β) are not. On the other hand, mTor, but not GSK3β, mediates the effects of Reelin on the growth and branching of dendrites of hippocampal neurons. In addition, PI3K fosters radial migration of cortical neurons through the intermediate zone, an effect that is independent of Reelin and Akt.

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

2000 ◽  
Vol 60 (3) ◽  
pp. 321-327 ◽  
Author(s):  
Kazuhiro Honda ◽  
Hideyuki Sawada ◽  
Takeshi Kihara ◽  
Makoto Urushitani ◽  
Tomoki Nakamizo ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Phosphatidylinositol 3 Kinase ◽  
Cultured Cortical Neurons ◽  
Phosphatidylinositol 3

scholarly journals Involvement of the Phosphatidylinositol 3-Kinase/Rac1 and Cdc42 Pathways in Radial Migration of Cortical Neurons

2004 ◽  
Vol 280 (6) ◽  
pp. 5082-5088 ◽  
Author(s):  
Daijiro Konno ◽  
Saori Yoshimura ◽  
Kei Hori ◽  
Hisato Maruoka ◽  
Kenji Sobue
Keyword(s):  
Cortical Neurons ◽  
Phosphatidylinositol 3 Kinase ◽  
Radial Migration ◽  
Phosphatidylinositol 3
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