Development of Thyroid-Stimulating Hormone Beta Subunit-Producing Cells in the Chicken Embryonic Pituitary Gland

2004 ◽  
Vol 177 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Kazuaki Nakamura ◽  
Atushi Iwasawa ◽  
Hinako Kidokoro ◽  
Masazumi Komoda ◽  
Jun Zheng ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Thyroid Stimulating Hormone ◽  
Beta Subunit ◽  
Stimulating Hormone

Posttraumatic Anterior Hypopituitarism—Revisited: The Role of TRH Provocative Release of Prolactin in the Confirmation of Anterior Pituitary Damage

PEDIATRICS ◽  
1977 ◽  
Vol 59 (6) ◽  
pp. 948-950
Author(s):  
David R. Brown ◽  
J. Michael McMillin
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Thyroid Stimulating Hormone ◽  
Anterior Pituitary Gland ◽  
Serum Prolactin ◽  
Pituitary Insufficiency ◽  
Closed Head Trauma ◽  
One Year ◽  
Stimulating Hormone

We have previously reported a case of anterior pituitary insufficiency in a 14-year-old girl following closed head trauma.1 Endocrine evaluation one year after her accident revealed hypopituitarism manifested by cachexia, hypothyroidism, hypogonadism, and hypoadrenocorticism. Laboratory studies demonstrated deficiencies of adrenocorticotropic hormone, thyroid-stimulating hormone (TSH), growth hormone, and gonadotropic hormones (follicle-stimulating hormone and luteinizing hormone). We postulated that her hypopituitarism was due to anterior pituitary gland destruction rather than stalk section or hypothalamic damage. We have recently measured her serum prolactin concentrations following provocative stimulation with thyrotropin-releasing hormone (TRH), and these results strengthen the evidence for direct anterior pituitary gland destruction and provide a more complete delineation of her endocrinologic function.

scholarly journals Immunochemical characterization of two thyroid-stimulating hormone β-subunit epitopes

1995 ◽  
Vol 308 (1) ◽  
pp. 203-210 ◽  
Author(s):  
W D Fairlie ◽  
P G Stanton ◽  
M T W Hearn
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Thyroid Stimulating Hormone ◽  
Beta Subunit ◽  
Human Thyroid ◽  
Lysine Residues ◽  
Sequence Region ◽  
The Relationship ◽  
Stimulating Hormone

The epitopes of human thyroid-stimulating hormone (hTSH) recognized by two murine monoclonal antibodies (MAbs), designated MAb 279 and MAb 299, have been characterized. These MAbs are highly specific for the beta-subunit of TSH. The epitope recognized by MAb 279 appears to be completely conserved between bovine and human TSH and partially conserved in the porcine species. The TSH beta-subunit epitope recognized by MAb 299 is only partially conserved between the human, bovine and porcine species. Both MAbs are capable of inhibiting the binding of TSH to its receptor in a TSH radioreceptor assay, indicating that the epitopes either coincide or are located close to the TSH beta-subunit receptor-binding sites. The carbohydrate moieties of the TSH beta-subunit appear to play little or no role in the epitope recognition by MAb 279 or MAb 299 while the integrity of the disulphide bonds are essential. The epitopic recognition may also involve lysine residues, as determined by the immunoreactivity with both MAbs following citraconylation of TSH. In addition, the amino acid sequence region between residues bTSH beta 34-44 could be excised by trypsin digestion of bovine TSH beta (bTSH beta) without eliminating epitopic recognition by either MAb. These results provide further insight into the relationship between the structure of the TSH beta-subunit epitopes and location of the receptor-binding sites.

EFFECT OF MORPHINE ON THE RELEASE OF THYROID-STIMULATING HORMONE STIMULATED BY EXPOSURE TO COLD, THYROIDECTOMY AND THE ADMINISTRATION OF THYROTROPHIN RELEASING HORMONE IN MALE RATS

1980 ◽  
Vol 86 (2) ◽  
pp. 357-362 ◽  
Author(s):  
TAKAMURA MURAKI ◽  
TERUO NAKADATE ◽  
YUKIKO TOKUNAGA ◽  
RYUICHI KATO
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Inhibitory Effect ◽  
Thyroid Stimulating Hormone ◽  
Male Rats ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Exposure To Cold ◽  
Serum Tsh ◽  
Stimulating Hormone

Morphine reduced the release of thyroid-stimulating hormone (TSH) which was stimulated by exposure to cold and by thyroidectomy as well as reducing the basal level of TSH in the serum of male rats. The inhibitory effect of morphine was antagonized by naloxone which did not enhance the basal or cold-induced TSH release. Pretreatment with morphine did not reduce the release of TSH induced by exogenous thyrotrophin-releasing hormone (TRH) but enhanced it. This effect of morphine was also antagonized by naloxone. The above results suggested that the effect of morphine in reducing levels of serum TSH was not mediated by blocking the effect of TRH on the anterior pituitary gland, but that it was probably mediated by the inhibition of the release of TRH.

Localization of cells producing thyroid stimulating hormone in the pituitary gland of the domestic drake

1979 ◽  
Vol 198 (1) ◽  
Author(s):  
P.J. Sharp ◽  
R.B. Chiasson ◽  
M.M. El Tounsy ◽  
H. Klandorf ◽  
W.J. Radke
Keyword(s):  
Pituitary Gland ◽  
Thyroid Stimulating Hormone ◽  
Stimulating Hormone

SOME EFFECTS OF MAMMALIAN THYROID STIMULATING HORMONE, ELASMOBRANCH PITUITARY GLAND EXTRACTS AND TEMPERATURE ON THYROIDAL ACTIVITY IN NEWLY HATCHED DOGFISH (SCYLIORHINUS CANICULUS)

1961 ◽  
Vol 22 (4) ◽  
pp. 395-NP ◽  
Author(s):  
J. N. DENT ◽  
J. M. DODD
Keyword(s):  
Pituitary Gland ◽  
Low Dose ◽  
Thyroid Stimulating Hormone ◽  
Adult Brain ◽  
Effect Of Temperature ◽  
High Dose ◽  
Aqueous Extracts ◽  
Iodine Metabolism ◽  
Dose Levels ◽  
Stimulating Hormone

SUMMARY 1. Groups of recently hatched dogfish (Scyliorhinus caniculus) were given a series of injections of mammalian thyroid stimulating hormone (TSH) at three dose levels, or of aqueous extracts of each of the three lobes of the adult elasmobranch pituitary gland. Control animals received injections of distilled water or extract of adult brain. The uptake of 131I by the thyroid was measured subsequent to the injections and the histology of the thyroid was studied. The experiments were conducted over a range of temperatures, thus producing data on the effect of temperature variation on thyroidal activity. 2. The uptake of 131I by the thyroid gland is very markedly enhanced by a high dose of mammalian TSH (1·00 i.u.) and is significantly increased by an intermediate dose (0·10 i.u. TSH). Enhancement by a very low dose (0·01 i.u. TSH) is doubtful, the observed increase in uptake of 131I being significant only at the 10% level. The highest dose also accelerated folliculogenesis and induced hyperplastic changes in the thyroid. 3. There were indications that the extract of the ventral lobe of the adult elasmobranch pituitary contains a thyroid-stimulating principle. 4. The rate of iodine metabolism increases directly with the temperature over the range 8·6–13·6° C.

scholarly journals Assignment of the gene for the beta subunit of thyroid-stimulating hormone to the short arm of human chromosome 1.

1986 ◽  
Vol 83 (6) ◽  
pp. 1822-1826 ◽  
Author(s):  
N. C. Dracopoli ◽  
W. J. Rettig ◽  
G. K. Whitfield ◽  
G. J. Darlington ◽  
B. A. Spengler ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Thyroid Stimulating Hormone ◽  
Beta Subunit ◽  
Chromosome 1 ◽  
Human Chromosome 1 ◽  
Stimulating Hormone

scholarly journals BODY IMMUNOPROPHYLAXIS OF PREGNANT AND NEWLY-CALVED COWS

REPORTS ◽  
2021 ◽  
Vol 335 (1) ◽  
pp. 39-46
Author(s):  
V.G. Semenov ◽  
V.G. Tyurin ◽  
D.A. Baimukanov ◽  
E.P. Simurzina ◽  
S.G. Kondruchina ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Thyroid Stimulating Hormone ◽  
Anterior Pituitary Gland ◽  
The Body ◽  
Macrophage Receptors ◽  
Service Period ◽  
New Generation ◽  
Opening Up ◽  
Stimulating Hormone

The research was performed to identify the most effective bio immunostimulant. We used PS-2 and Prevention-N-E biologicals developed on the basis of the Chuvash State Agrarian University, as well as widely used in veterinary practice - PDE and E-selenium. Injection of PS-2 and Prevention-NE preparations to dry cows at a dose of 10.0 ml three times 45-40, 25-20 and 15-10 days before calving, as well as PDE and E-selenium at a dose of 20.0 and 10.0 ml 20 days before calving, respectively, prevents postpartum diseases. The mechanism of action of the PS-2 and Prevention-N-E drugs developed and tested by us is manifested, first of all, due to the consecutive processes of macrophage activation, as a result of the action of polysaccharide corpuscles and drug components on macrophage receptors. Secondly, information from the receptors of macrophages and chemoreceptors is transmitted along the afferent pathway to the cerebral cortex, then the signals go to the hypothalamus, which leads to liberin secretion by the nuclei of the ashen tuber of the hypothalamus. Liberins, in turn, increase the release of hormones by the anterior pituitary gland - the adenohypophysis. The anterior pituitary gland releases tropic hormones: somatotropic hormone, adrenocorticotropic hormone, thyroid-stimulating hormone, follicle-stimulating hormone, etc. These hormones are involved in metabolic processes in the body. Under the influence of preparations, in cows the time of membranes sweep was reduced, the risk of uterus subinvolution and endometritis decreased. In cows, the timing of the onset of estrus, the insemination rate, and the service period were shortened, and the conception rate increased in one estrus. In such a way, against the background of the use of biologicals with the help of nonspecific adaptive reactions, the body retains the relative constancy of the internal environment necessary for life - homeostasis, and it actively resists the adverse effects of the external environment, increasing its phylactic power. Consequently, new opportunities are opening up for the implementation of the reproductive and productive qualities of cattle due to the body immunoprophylaxis with complex biological products of a new generation.

Sign in / Sign up

Export Citation Format

Share Document