Establishment of a New Cell Line with Neuronal Differentiation Derived from Small Cell Neuroendocrine Carcinoma of the Maxillary Sinus

Oncology ◽  
2004 ◽  
Vol 66 (3) ◽  
pp. 234-243 ◽  
Author(s):  
Kazuma Noguchi ◽  
Masahiro Urade ◽  
Hiromitsu Kishimoto ◽  
Junko Kuroda ◽  
Kuniyasu Moridera ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroendocrine Carcinoma ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
New Cell Line

scholarly journals Primary Small Cell Undifferentiated (Neuroendocrine) Carcinoma of the Maxillary Sinus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Santosh Kumar Yadav ◽  
Premalatha Shetty
Keyword(s):  
Maxillary Sinus ◽  
Neuroendocrine Carcinoma ◽  
Poor Prognosis ◽  
Concurrent Chemoradiotherapy ◽  
Neck Region ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Head And Neck Region ◽  
Clinical Behavior ◽  
Aggressive Clinical Behavior

Primary small cell neuroendocrine carcinoma (SNEC) of the paranasal sinuses is an extremely rare and distinctive tumor with aggressive clinical behavior. Moreover, SNECs originating in the head and neck region have been reported to be highly aggressive and to have a poor prognosis. This report describes a patient with a maxillary sinus SNEC who was successfully treated with neoadjuvant chemotherapy and concurrent chemoradiotherapy.

Small cell neuroendocrine carcinoma of the maxillary sinus?A case report and nude mouse transplantable model

Head & Neck ◽  
2002 ◽  
Vol 24 (5) ◽  
pp. 491-496 ◽  
Author(s):  
Kazuma Noguchi ◽  
Masahiro Urade ◽  
Kazunari Sakurai ◽  
Norihiko Nishimura ◽  
Susumu Hashitani ◽  
...  
Keyword(s):  
Case Report ◽  
Maxillary Sinus ◽  
Nude Mouse ◽  
Neuroendocrine Carcinoma ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma

scholarly journals Mixed large and small cell neuroendocrine carcinoma and endometrioid carcinoma of the endometrium with high microsatellite instability: A case report and literature review

2021 ◽  
Vol 9 ◽  
pp. 2050313X2199920
Author(s):  
Kotaro Inoue ◽  
Kentaro Kai ◽  
Shimpei Sato ◽  
Haruto Nishida ◽  
Koji Hirakawa ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Neuroendocrine Carcinoma ◽  
Immune Checkpoint Blockade ◽  
Japanese Woman ◽  
Endometrial Biopsy ◽  
Small Cell ◽  
Endometrioid Carcinoma ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Mutation Burden ◽  
Solid Part

A 65-year-old, gravida 3, para 2 Japanese woman was referred to our hospital for symptomatic thickening of the endometrial lining. Endocervical and endometrial cytology revealed an adenocarcinoma. The endometrial biopsy specimen was mixed, with a glandular part diagnosed as endometrioid carcinoma and a solid part diagnosed as high-grade mixed large and small cell neuroendocrine carcinoma (L/SCNEC). She underwent extra-fascial hysterectomy with bilateral salpingo-oophorectomy, complete pelvic and para-aortic lymphadenectomy, and omentectomy (FIGO IIIB, pT3b pN0 M0). She currently has no deleterious germline mutation, but high tumor mutation burden and high microsatellite instability (MSI) were identified. She underwent six cycles of platinum-based frontline chemotherapy and achieved complete remission. Immune checkpoint blockade therapy is a promising second-line therapy for MSI-high solid tumors. However, the MSI or mismatch repair (MMR) status of endometrial L/SCNEC remains unclear in the literature. Universal screening for MSI/MMR status is needed, particularly for a rare and aggressive disease.

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