scholarly journals Primary Small Cell Undifferentiated (Neuroendocrine) Carcinoma of the Maxillary Sinus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Santosh Kumar Yadav ◽  
Premalatha Shetty
Keyword(s):  
Maxillary Sinus ◽  
Neuroendocrine Carcinoma ◽  
Poor Prognosis ◽  
Concurrent Chemoradiotherapy ◽  
Neck Region ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Head And Neck Region ◽  
Clinical Behavior ◽  
Aggressive Clinical Behavior

Primary small cell neuroendocrine carcinoma (SNEC) of the paranasal sinuses is an extremely rare and distinctive tumor with aggressive clinical behavior. Moreover, SNECs originating in the head and neck region have been reported to be highly aggressive and to have a poor prognosis. This report describes a patient with a maxillary sinus SNEC who was successfully treated with neoadjuvant chemotherapy and concurrent chemoradiotherapy.

Hypopharyngeal Squamous Cell Carcinoma and Laryngeal Neuroendocrine Carcinoma Colliding in the Aryepiglottic Fold: A Case Report

2017 ◽  
Vol 103 (1_suppl) ◽  
pp. S1-S4 ◽  
Author(s):  
Roberta Marangoni ◽  
Simone Mauramati ◽  
Giulia Bertino ◽  
Antonio Occhini ◽  
Marco Benazzo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Neck Region ◽  
Collision Tumor ◽  
Small Cell ◽  
Head And Neck Region

Purpose A collision tumor consists of 2 different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck region they are rare, with only 4 cases reported in the larynx. Case report A 60-year-old heavy smoker complained of a left submandibular lesion in October 2014. The lesion was excised and showed a poorly differentiated carcinoma, suggestive for adenocarcinoma. After a positron emission tomography-computed tomography scan showed increased metabolic activity in the left laterocervical region and right vocal cord, the patient underwent endoscopic biopsy of the lesion of the left piriform sinus, which was positive for moderately differentiated squamous cell carcinoma (SCC). He was then submitted to circular pharyngolaryngectomy, reconstruction with a radial forearm free flap, and bilateral neck dissection. The histopathologic examination showed an in situ and microinvasive SCC of the left pyriform sinus colliding with a high-grade, non-small-cell neuroendocrine carcinoma of the larynx. Conclusions To our knowledge, this is the first case described of laryngeal collision tumor comprising a neuroendocrine component. The choice of treatment of this kind of lesion is difficult because of the presence of 2 different histologies and of the controversial prognostic correlation of non-small-cell neuroendocrine neoplasms of the head and neck region.

Establishment of a New Cell Line with Neuronal Differentiation Derived from Small Cell Neuroendocrine Carcinoma of the Maxillary Sinus

Oncology ◽  
2004 ◽  
Vol 66 (3) ◽  
pp. 234-243 ◽  
Author(s):  
Kazuma Noguchi ◽  
Masahiro Urade ◽  
Hiromitsu Kishimoto ◽  
Junko Kuroda ◽  
Kuniyasu Moridera ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroendocrine Carcinoma ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
New Cell Line

scholarly journals Primary Small Cell Neuroendocrine Carcinoma of Paranasal Sinuses

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Maliha Khan ◽  
Sobia Nizami ◽  
Aibek E. Mirrakhimov ◽  
Benjamin Maughan ◽  
Justin A. Bishop ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Paranasal Sinuses ◽  
Poor Prognosis ◽  
Cell Cancer ◽  
Distant Metastases ◽  
Management Plan ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Cervical Lymph Nodes ◽  
Platinum Based Chemotherapy

Small cell neuroendocrine carcinoma of the paranasal sinuses is an extremely rare and aggressive neoplasm. Despite aggressive management, the tumor carries a poor prognosis, with a high risk of local recurrence or distant metastases. The management strategy is based on that for pulmonary small cell cancer and includes platinum-based chemotherapy combined with radiotherapy. We are reporting a case of an 89-year-old female patient diagnosed with small cell carcinoma of right-sided ethmoid and sphenoid sinuses. The tumor was found to have invaded the right orbit and anterior cranial fossa. Metastases to cervical lymph nodes and bone were also found. Due to the extended stage and poor prognosis of the patient, the management plan is palliative chemoradiotherapy.

scholarly journals Correction to: Co-expression of SOX2 and HR-HPV RISH predicts poor prognosis in small cell neuroendocrine carcinoma of the uterine cervix

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shi-Wen Zhang ◽  
Rong-Zhen Luo ◽  
Xiao-Ying Sun ◽  
Xia Yang ◽  
Hai-Xia Yang ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Small Cell Neuroendocrine Tumor of Base of Tongue - Treatment Strategies of A Rare Entity

2014 ◽  
Vol 8 (3) ◽  
pp. 181-183
Author(s):  
S Singh ◽  
A Khurana ◽  
P Kaur ◽  
AK Chauhan ◽  
R Sen
Keyword(s):  
Neuroendocrine Tumor ◽  
Treatment Strategies ◽  
Neck Region ◽  
Small Cell ◽  
Common Site ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Epithelial Tumor ◽  
Head And Neck Region ◽  
Base Of Tongue ◽  
Poorly Differentiated

ABSTRACT Neuroendocrine tumors are rare in head and neck region, while larynx is the most common site of presentation where they represent 0.5-1.0% of epithelial tumor, whereas only few cases of small cell neuroendocrine tumor of base of tongue has been reported so far. A 56-year old male presented with growth base of tongue. After through investigations the growth confirmed as a case of poorly differentiated high grade small cell neuroendocrine carcinoma and was clinically labeled as stage III (T3N0M0). The patient was treated with radiotherapy and combination chemotherapy. Presently the patient is having stable disease without any symptoms.

scholarly journals Co-expression of SOX2 and HR-HPV RISH predicts poor prognosis in small cell neuroendocrine carcinoma of the uterine cervix

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shi-Wen Zhang ◽  
Rong-Zhen Luo ◽  
Xiao-Ying Sun ◽  
Xia Yang ◽  
Hai-Xia Yang ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Univariate Analysis ◽  
Disease Free Survival ◽  
Clinicopathological Characteristics ◽  
Small Cell ◽  
Hazard Ratio ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Specific Subgroup

Abstract Background Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer involving the human papilloma virus (HPV), and has few available treatments. The present work aimed to assess the feasibility of SOX2 and HPV statuses as predictive indicators of SCNEC prognosis. Methods The associations of SOX2 and/or high-risk (HR)-HPV RNA in situ hybridization (RISH) levels with clinicopathological characteristics and prognostic outcomes for 88 neuroendocrine carcinoma (NEC) cases were analyzed. Results Among these patients with SCNEC, SOX2, P16INK4A and HR-HPV RISH expression and SOX2/HR-HPV RISH co-expression were detected in 68(77.3%), 76(86.4%), 73(83.0%), and 48(54.5%), respectively. SOX2-positive and HR-HPV RISH-positive SCNEC cases were associated with poorer overall survival (OS, P = 0.0170, P = 0.0451) and disease-free survival (DFS, P = 0.0334, P = 0.0309) compared with those expressing low SOX2 and negative HR-HPV RISH. Alternatively, univariate analysis revealed that SOX2 and HR-HPV RISH expression, either separately or in combination, predicted the poor prognosis of SCNEC patients. Multivariate analysis revealed that the co-expression of SOX2 with HR-HPV RISH may be an independent factor of OS [hazard ratio = 3.597; 95% confidence interval (CI): 1.085–11.928; P = 0.036] and DFS [hazard ratio = 2.880; 95% CI: 1.199–6.919; P = 0.018] prediction in SCNEC. Conclusions Overall, the results of the present study suggest that the co-expression of SOX2 with HR-HPV RISH in SCNEC may represent a specific subgroup exhibiting remarkably poorer prognostic outcomes compared with the expression of any one marker alone.

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