Gonadal Function and Its Disorders in Simple Obesity and in Prader-Willi Syndrome

2003 ◽  
pp. 140-155 ◽  
Author(s):  
G. Grugni ◽  
F. Morabito ◽  
A. Crinò
Keyword(s):  
Prader Willi Syndrome ◽  
Gonadal Function ◽  
Simple Obesity

scholarly journals Comparison of Frequency and Severity of Sleep-Related Breathing Disorders in Children with Simple Obesity and Paediatric Patients with Prader–Willi Syndrome

2021 ◽  
Vol 11 (2) ◽  
pp. 141
Author(s):  
Agnieszka Lecka-Ambroziak ◽  
Marta Wysocka-Mincewicz ◽  
Anna Świercz ◽  
Małgorzata Jędrzejczak ◽  
Mieczysław Szalecki
Keyword(s):  
Insulin Resistance ◽  
Apnea Hypopnea Index ◽  
Oral Glucose ◽  
Prader Willi Syndrome ◽  
Model Assessment ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Simple Obesity ◽  
Rhgh Treatment ◽  
Group 1

Sleep-related breathing disorders (SRBDs) can be present in children with simple obesity and with Prader–Willi syndrome (PWS) and influence an individual diagnostic and treatment approach. We compared frequency and severity of SRBDs in children with simple obesity and with PWS, both without and on recombinant human growth hormone (rhGH) treatment, and correlation of SRBDs with insulin resistance tests. A screening polysomnography-polygraphy (PSG), the oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were analysed in three groups of patients—with simple obesity (group 1, n = 30, mean age 14.2 years), patients with PWS without the rhGH therapy (group 2, n = 8, mean age 13.0 years) and during the rhGH treatment (group 3, n = 17, mean age 8.9 years). The oxygen desaturation index (ODI) was significantly higher in groups 2 and 3, compared to group 1 (p = 0.00), and hypopnea index (HI) was higher in group 1 (p = 0.03). Apnea–hypopnea index (AHI) and apnea index (AI) results positively correlated with the insulin resistance parameters in groups 1 and 3. The PSG values worsened along with the increasing insulin resistance in children with simple obesity and patients with PWS treated with rhGH that may lead to a change in the patients’ care.

scholarly journals Sexual dichotomy of gonadal function in Prader–Willi syndrome from early infancy through the fourth decade

2015 ◽  
Vol 30 (11) ◽  
pp. 2587-2596 ◽  
Author(s):  
H.J. Hirsch ◽  
T. Eldar-Geva ◽  
F. Bennaroch ◽  
Y. Pollak ◽  
V. Gross-Tsur
Keyword(s):  
Early Infancy ◽  
Prader Willi Syndrome ◽  
Gonadal Function ◽  
Fourth Decade

scholarly journals Body Composition and Fatness Patterns in Prader-Willi Syndrome: Comparison with Simple Obesity*

Obesity ◽  
2006 ◽  
Vol 14 (10) ◽  
pp. 1685-1690 ◽  
Author(s):  
Mariana F. Theodoro ◽  
Zohreh Talebizadeh ◽  
Merlin G. Butler
Keyword(s):  
Body Composition ◽  
Prader Willi Syndrome ◽  
Simple Obesity

scholarly journals Gonadal function and testicular histology in males with Prader-Willi syndrome

2018 ◽  
Vol 2 (1) ◽  
pp. e00049 ◽  
Author(s):  
Satoko Matsuyama ◽  
Futoshi Matsui ◽  
Keiko Matsuoka ◽  
Masashi Iijima ◽  
Makoto Takeuchi ◽  
...  
Keyword(s):  
Prader Willi Syndrome ◽  
Gonadal Function ◽  
Testicular Histology

scholarly journals Importance of reward and prefrontal circuitry in hunger and satiety: Prader–Willi syndrome vs simple obesity

2011 ◽  
Vol 36 (5) ◽  
pp. 638-647 ◽  
Author(s):  
L M Holsen ◽  
C R Savage ◽  
L E Martin ◽  
A S Bruce ◽  
R J Lepping ◽  
...  
Keyword(s):  
Prader Willi Syndrome ◽  
Simple Obesity ◽  
Prefrontal Circuitry

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

Prader-willi syndrome: Genetics and behavior

1996 ◽  
Vol 71 (4) ◽  
pp. 187-212 ◽  
Author(s):  
Travis Thompson ◽  
Merlin Butler ◽  
William MacLean ◽  
Beth Joseph
Keyword(s):  
Prader Willi Syndrome ◽  
And Behavior
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