Circadian Determinations of Cortisol, Prolactin and Melatonin in Chronic Methyl-Phenyl-Tetrahydropyridine-Treated Monkeys

2003 ◽  
Vol 78 (2) ◽  
pp. 118-128 ◽  
Author(s):  
Carlos Barcia ◽  
Víctor Bautista ◽  
Angel Sánchez-Bahillo ◽  
Emiliano Fernández-Villalba ◽  
Juana-María Navarro-Ruis ◽  
...  
Keyword(s):  
Methyl Phenyl Tetrahydropyridine ◽  
Methyl Phenyl

scholarly journals Levodopa-Induced Dyskinesia: Facts and Fancy. What Does the MPTP Monkey Model Tell Us?

1992 ◽  
Vol 19 (S1) ◽  
pp. 134-137 ◽  
Author(s):  
Paul J. Bédard ◽  
Baltazar Gomez Mancilla ◽  
Pierre Blanchette ◽  
Céline Gagnon ◽  
Thérèse Di Paolo
Keyword(s):  
Dopamine Receptors ◽  
New Drugs ◽  
Monkey Model ◽  
Single Receptor ◽  
Denervation Supersensitivity ◽  
Drug Naïve ◽  
Methyl Phenyl Tetrahydropyridine ◽  
Antiparkinsonian Therapy ◽  
Methyl Phenyl

ABSTRACT:Levodopa-induced dyskinesia, one of the most frequent long-term side effects of antiparkinsonian therapy, is often attributed to denervation supersensitivity of dopamine receptors and perhaps more specifically the D-1 receptor. The available evidence based not only on clinico-pathological studies in patients but also on results of experiments performed on methyl-phenyl-tetrahydropyridine (MPTP)-treated monkeys suggests that the mechanisms may be more complex than heretofore believed. Thus it appears that no single receptor is the sole culprit, that some form of denervation supersensitivity is probably involved but not in the form of increased density of dopamine receptors. Moreover, other neurotransmitter systems must be considered such as GABA, excitatory aminoacids and peptides. The MPTP monkey model remains very useful for predicting the potential of new drugs for inducing dyskinesia. Such trials however must be performed in drug-naive animals.

Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity

2005 ◽  
Vol 93 (2) ◽  
pp. 493-501 ◽  
Author(s):  
Bruno Conti ◽  
Shuei Sugama ◽  
Jacinta Lucero ◽  
Raphaelle Winsky-Sommerer ◽  
Sebastian A. Wirz ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Methyl Phenyl Tetrahydropyridine ◽  
Methyl Phenyl

Degradation in a Methyl-phenyl Co-Polymeric Polysilane for LED Applications

2003 ◽  
Vol 769 ◽  
Author(s):  
Asha Sharma ◽  
Deepak ◽  
Monica Katiyar ◽  
Satyendra Kumar ◽  
V. Chandrasekhar ◽  
...  
Keyword(s):  
Thin Films ◽  
Molecular Weight ◽  
Light Source ◽  
Room Temperature ◽  
Light Exposure ◽  
Room Temperature Photoluminescence ◽  
Pl Spectrum ◽  
Pl Intensity ◽  
Methyl Phenyl

AbstractThe optical degradation of polysilane copolymer has been studied in spin cast thin films and solutions using light source of 325 nm wavelength. The room temperature photoluminescence (PL) spectrum of these films show a sharp emission at 368 nm when excited with a source of 325 nm. However, the PL intensity deteriorates with time upon light exposure. Further the causes of this degradation have been examined by characterizing the material for its transmission behaviour and changes occurring in molecular weight as analysed by GPC data.

Proton magnetic resonance study of the conformation of the pyrrolidine ring in some proline-thiohydantoins

1988 ◽  
Vol 53 (11) ◽  
pp. 2503-2510 ◽  
Author(s):  
Jef J. M. Sleeckx ◽  
Marc J. O. Anteunis ◽  
Frans A. M. Borremans
Keyword(s):  
Present Model ◽  
Coupling Constants ◽  
Proton Proton ◽  
Proton Coupling ◽  
Proton Magnetic Resonance Study ◽  
Vicinal Proton ◽  
Different Temperatures ◽  
Experimental Justification ◽  
State Assumption ◽  
Methyl Phenyl

The conformational behaviour of a series of N-substituted thiohydantoins of proline was studied by proton NMR. The pseudorotational parameters of the proline moiety were calculated from the ten vicinal proton-proton coupling constants assuming a two state equilibrium (N ⇋ S). The effect of the different substituents (methyl, phenyl, para-nitrophenyl) at the thiohydantoin nitrogen on the conformation of the pyrrolidine rings is discussed. The spectra of proline-N-methylthiohydantoin were recorded at different temperatures in octadeuterotoluene solution. The conformational analysis of these spectra showed that the ratio of the populations of the N and S forms changes considerably with temperature, while the conformational identity of both the N and S forms remains strictly preserved. These facts provide an additional experimental justification of the two-state assumption, at least so for the present model compounds.

Alkyl-substituted bis(4-((9H-fluoren-9-ylidene)methyl)phenyl)thiophenes: weakening of intermolecular interactions and additive-assisted crystallization

CrystEngComm ◽  
2021 ◽  
Vol 23 (14) ◽  
pp. 2654-2664
Author(s):  
Alina A. Sonina ◽  
Christina S. Becker ◽  
Anatoly D. Kuimov ◽  
Inna K. Shundrina ◽  
Vladislav Yu. Komarov ◽  
...  
Keyword(s):  
Intermolecular Interactions ◽  
Methyl Phenyl

Effect of alkyl substituents and an additive on crystallization and intermolecular interactions of bis(4-((9H-fluoren-9-ylidene)methyl)phenyl)thiophenes is revealed.

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