Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes

2002 ◽  
Vol 99 (1-4) ◽  
pp. 66-74 ◽  
Author(s):  
Y. Goto ◽  
M. Gomez ◽  
N. Brockdorff ◽  
R. Feil
Keyword(s):  
Histone Methylation ◽  
Histone Methylation And Acetylation

scholarly journals BCL-6 suppresses miR-142-3p/5p expression in SLE CD4+ T cells by modulating histone methylation and acetylation of the miR-142 promoter

2019 ◽  
Vol 17 (5) ◽  
pp. 474-482 ◽  
Author(s):  
Shu Ding ◽  
Qing Zhang ◽  
Shuangyan Luo ◽  
Lihua Gao ◽  
Jinhua Huang ◽  
...  
Keyword(s):  
T Cells ◽  
Histone Methylation ◽  
Cd4 T Cells ◽  
Histone Methylation And Acetylation

scholarly journals Chromatin remodeling in mammalian embryos

Reproduction ◽  
2018 ◽  
Vol 155 (3) ◽  
pp. R147-R158 ◽  
Author(s):  
Birgit Cabot ◽  
Ryan A Cabot
Keyword(s):  
Chromatin Remodeling ◽  
Histone Methylation ◽  
Mammalian Species ◽  
Epigenetic Changes ◽  
Mammalian Embryo ◽  
Mammalian Embryos ◽  
Epigenetic Remodeling ◽  
Histone Methylation And Acetylation

The mammalian embryo undergoes a dramatic amount of epigenetic remodeling during the first week of development. In this review, we discuss several epigenetic changes that happen over the course of cleavage development, focusing on covalent marks (e.g., histone methylation and acetylation) and non-covalent remodeling (chromatin remodeling via remodeling complexes; e.g., SWI/SNF-mediated chromatin remodeling). Comparisons are also drawn between remodeling events that occur in embryos from a variety of mammalian species.

Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy

2019 ◽  
Vol 19 (15) ◽  
pp. 1350-1362 ◽  
Author(s):  
Pei Sun ◽  
Shu-Jing Zhang ◽  
Semenov Maksim ◽  
Yong-Fang Yao ◽  
Hong-Min Liu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Histone Methylation ◽  
Essential Role ◽  
Epigenetic Modification ◽  
Tissue Homeostasis ◽  
Biological Behavior ◽  
Promising Target ◽  
Disease Therapy ◽  
And Function ◽  
Histone Methylation And Acetylation

Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essential role in determining the biological behavior of cells. In particular, changes of DNA methylation, histone methylation and acetylation regulated by the corresponding epigenetic enzymes, can directly control macrophages differentiation and change their functions under different conditions. In addition, epigenetic enzymes also have become anti-tumor targets, such as HDAC, LSD1, DNMT, and so on. In this review, we presented an overview of the latest progress in the study of macrophages phenotype and function regulated by epigenetic modifications, including DNA methylation and histone modifications, to better understand how epigenetic modification controls macrophages phenotype and function in inflammation-associated diseases, and the application prospect in anti-tumor.

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