scholarly journals The Effects of Growth Hormone and Sex Steroid on Lean Body Mass, Fat Mass, Muscle Strength, Cardiovascular Endurance and Adverse Events in Healthy Elderly Women and Men

2003 ◽  
Vol 60 (1) ◽  
pp. 121-124 ◽  
Author(s):  
S. Mitchell Harman ◽  
Marc R. Blackman
Keyword(s):  
Growth Hormone ◽  
Muscle Strength ◽  
Adverse Events ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Elderly Women ◽  
Sex Steroid ◽  
Healthy Elderly ◽  
Cardiovascular Endurance

Interactions of Body Fat and Muscle Mass with Substrate Concentrations and Fasting Insulin Levels in Adults with Growth Hormone Deficiency

1994 ◽  
Vol 87 (2) ◽  
pp. 201-206 ◽  
Author(s):  
F. Salomon ◽  
R. C. Cuneo ◽  
A. M. Umpleby ◽  
P. H. Sönksen
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Insulin Level ◽  
Hormone Deficiency ◽  
Fasting Plasma ◽  
Fasting Plasma Insulin ◽  
Substrate Concentrations

1. Adults with growth hormone deficiency have an abnormal body composition. Alterations in body composition are closely related to substrate concentrations and insulin action. The lack of growth hormone has been associated with increased insulin sensitivity. 2. We investigated the correlations of body composition with fasting insulin levels and substrate concentrations in 24 adults with growth hormone deficiency over a wide range of adiposity (body mass index 18.8-42.3 kg/m2). 3. Lean body mass was measured by total body potassium, computer tomography of the thigh and urinary creatinine excretion. Muscle fibre distribution was evaluated from vastus lateralis biopsies. Fat mass was assessed by skinfold thickness measurements, computer tomography of the thigh, and waist and hip girth. 4. Fasting plasma insulin level increased with fat mass (r = 0.67, P = 0.0004) and with waist girth (r = 0.76, P = 0.0001). Fasting plasma insulin level increased with fasting plasma glucose level (r = 0.53, P = 0.01). Fasting plasma glucose level in turn was positively correlated with lean body mass (r = 0.49, P = 0.01) and with total thigh muscle area (r = 0.54, P = 0.01). There was no correlation between lean body mass and fat mass (r = 0.17, not significant) nor between muscle fibre types and fat mass or fat distribution. Fasting plasma insulin level showed no correlation with any measurement of lean body mass or muscle fibre type. 5. These data demonstrate that the presence of obesity is associated with hyperinsulinaemia as the result of insulin resistance in adults with growth hormone deficiency, which could contribute to the increased cardiovascular mortality in adults with growth hormone deficiency.

GENDER DIFFERENCE OF KNEE JOINT TORQUE DURING MAXIMAL VOLUNTARY CONTRACTION IN THE ELDERLY

2019 ◽  
Vol 19 (07) ◽  
pp. 1940036
Author(s):  
JUNGHYUK KO ◽  
YU-RI KWON ◽  
YOON-HYEOK CHOI ◽  
GWANG-MOON EOM ◽  
JI-WON KIM
Keyword(s):  
Muscle Strength ◽  
Gender Difference ◽  
Knee Joint ◽  
Body Mass ◽  
Elderly Women ◽  
Peak Torque ◽  
Voluntary Contraction ◽  
Joint Torque ◽  
Elderly Men ◽  
Healthy Elderly

Reduced muscle strength is an important fall risk factor. The fall occurs more in elderly women than in elderly men. The aim of this study is to investigate muscle strength and the ability to generate rapid torque for knee joint in elderly men and women. Twenty healthy elderly participants (10 men and 10 women) performed maximal voluntary knee extension and flexion during concentric, isometric and eccentric conditions. The peak torque and rate of torque development (RTD) was normalized by each subject’s body mass. Independent [Formula: see text]-tests were employed in the comparison of elderly women with elderly men. Elderly women exhibited weaker isometric flexion and eccentric extension strength compared to elderly men ([Formula: see text]). Although there was no significant gender difference in isometric extension peak torque, RTD of elderly women was slower than it of elderly men ([Formula: see text]). In contrast, no significant gender differences were observed in concentric contraction condition ([Formula: see text]). These results indicate that the deteriorated RTD as well as muscle strength per body mass may be associated with a higher frequency of falls in elderly women than in elderly men. This study suggests that training of specific-contraction type should be considered for fall prevention in elderly women.

scholarly journals The impact of sarcopenic obesity on inflammation, lean body mass, and muscle strength in elderly women

2018 ◽  
Vol Volume 11 ◽  
pp. 443-449 ◽  
Author(s):  
Dahan da Cunha Nascimento ◽  
Samuel da Cunha Oliveira ◽  
Denis Cesar Leite Vieira ◽  
Silvana Schwerz Funghetto ◽  
Alessandro Oliveira Silva ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Lean Body Mass ◽  
Body Mass ◽  
Elderly Women ◽  
Sarcopenic Obesity ◽  
The Impact

scholarly journals The effect of resistance training programs on lean body mass in postmenopausal and elderly women: a meta-analysis of observational studies

2021 ◽  
Author(s):  
Ewan Thomas ◽  
Ambra Gentile ◽  
Nemanja Lakicevic ◽  
Tatiana Moro ◽  
Marianna Bellafiore ◽  
...  
Keyword(s):  
Resistance Training ◽  
Lean Body Mass ◽  
Muscle Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Muscle Hypertrophy ◽  
Elderly Women ◽  
Functional Changes ◽  
Training Frequency

AbstractAging and menopause are associated with morphological and functional changes which may lead to loss of muscle mass and therefore quality of life. Resistance training (RT) is an effective training mode to increase muscle mass. We reviewed the existing literature to identify studies implementing RT protocols and evaluating muscle hypertrophy exclusively in healthy, postmenopausal and elderly women. Participants’ age range was comprised between 50 and 80 years. The primary outcome observed was muscle hypertrophy. Fat mass was also evaluated, if available. PubMed and Web of Science were the screened database, and original articles written in English and published from 2000 up to 2020 were included. 26 articles were considered eligible and included. Quality assessment revealed a “moderate quality” of the included studies, however the majority of studies was able to reach level 4 of evidence and on overall grade of recommendation C. In total, data from 745 female participants subjected to different forms of resistance training were considered. Heterogeneity across studies was present regarding study design, intervention length (mean 16 weeks), training frequency (3 d/w), no. of exercises (n = 7.4) and participants’ age (65.8 ± 4.9 years). Small-to-moderate significant increases (k = 43; SMD = 0.44; 95% CI 0.28; 0.60; p < 0.0001) of lean body mass were observed in post-menopausal and elderly women, regardless of age, intervention period, weekly training frequency and no. of exercises. No effects were noted for fat mass (k = 17; SMD = 0.27; 95% CI − 0.02; 0.55; p = 0.07). Studies need to concentrate on providing information regarding training parameters to more effectively counteract the effects of aging and menopause on skeletal muscle mass.

scholarly journals Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns

2003 ◽  
Vol 94 (6) ◽  
pp. 2273-2281 ◽  
Author(s):  
Oscar E. Suman ◽  
Steve J. Thomas ◽  
Judy P. Wilkins ◽  
Ronald P. Mlcak ◽  
David N. Herndon
Keyword(s):  
Growth Hormone ◽  
Muscle Strength ◽  
Lean Body Mass ◽  
Body Mass ◽  
Recombinant Human Growth Hormone ◽  
Rehabilitation Program ◽  
Physical Rehabilitation ◽  
Percent Change ◽  
Home Based ◽  
The Mean

We tested the hypothesis that the administration of recombinant human growth hormone (rHGH) and exercise would increase lean body mass (LBM) and muscle strength in burned children to a greater extent than rHGH or exercise separately. Children, ages 7–17 yr, with >40% body surface area burned, were randomized into groups. One group (GHEX, n = 10) participated in a 12-wk in-hospital physical rehabilitation program supplemented with an exercise program and received 0.05 mg · kg−1· day−1of rHGH. A second exercising group (SALEX, n = 13) received saline. A third group (GH, n = 10) received a similar dose of rHGH as GHEX and participated in a 12-wk, home-based physical rehabilitation program without exercise. The fourth group (Saline, n = 11) received saline and participated in a 12-wk, home-based physical rehabilitation program without exercise. The mean (±SE) percent change in lean body mass after 12 wk was not significantly different between GHEX (9.0 ± 2.1%), SALEX (5.4 ± 1.6%), and GH (5.8 ± 1.8%) groups ( P = 0.33). However, the mean percent change in muscle strength was significantly greater in the GHEX (36.2 ± 5.4%) and SALEX (42.6 ± 10.0%) groups than in the GH (−7.4 ± 4.7%) or Saline (6.7 ± 4.4%) groups ( P = 0.008). In summary, rHGH GHEX, SALEX, and GH alone produced similar improvements in LBM. However, muscle strength was only increased via exercise.

scholarly journals Muscle strength and functional mobility in relation to lean body mass in free-living frail elderly women

1998 ◽  
Vol 52 (1) ◽  
pp. 45-53 ◽  
Author(s):  
H Payette ◽  
N Hanusaik ◽  
V Boutier ◽  
JA Morais ◽  
K Gray-Donald
Keyword(s):  
Muscle Strength ◽  
Lean Body Mass ◽  
Body Mass ◽  
Frail Elderly ◽  
Elderly Women ◽  
Functional Mobility ◽  
Free Living

Comparison of the Effect of Soy protein and Whey protein on Body Composition: A Meta-Analysis of Randomized Clinical Trials

2021 ◽  
pp. 1-27
Author(s):  
Masoome Piri Damaghi ◽  
Atieh Mirzababaei ◽  
Sajjad Moradi ◽  
Elnaz Daneshzad ◽  
Atefeh Tavakoli ◽  
...  
Keyword(s):  
Body Composition ◽  
Whey Protein ◽  
Lean Body Mass ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Soy Protein ◽  
Protein Supplementation ◽  
Body Fat Percentage ◽  
Fat Percentage

Abstract Background: Essential amino acids (EAAs) promote the process of regulating muscle synthesis. Thus, whey protein that contains higher amounts of EAA can have a considerable effect on modifying muscle synthesis. However, there is insufficient evidence regarding the effect of soy and whey protein supplementation on body composition. Thus, we sought to perform a meta-analysis of published Randomized Clinical Trials that examined the effect of whey protein supplementation and soy protein supplementation on body composition (lean body mass, fat mass, body mass and body fat percentage) in adults. Methods: We searched PubMed, Scopus, and Google Scholar, up to August 2020, for all relevant published articles assessing soy protein supplementation and whey protein supplementation on body composition parameters. We included all Randomized Clinical Trials that investigated the effect of whey protein supplementation and soy protein supplementation on body composition in adults. Pooled means and standard deviations (SD) were calculated using random-effects models. Subgroup analysis was applied to discern possible sources of heterogeneity. Results: After excluding non-relevant articles, 10 studies, with 596 participants, remained in this study. We found a significant increase in lean body mass after whey protein supplementation weighted mean difference (WMD: 0.91; 95% CI: 0.15, 1.67. P= 0.019). Subgroup analysis, for whey protein, indicated that there was a significant increase in lean body mass in individuals concomitant to exercise (WMD: 1.24; 95% CI: 0.47, 2.00; P= 0.001). There was a significant increase in lean body mass in individuals who received 12 or less weeks of whey protein (WMD: 1.91; 95% CI: 1.18, 2.63; P<0.0001). We observed no significant change between whey protein supplementation and body mass, fat mass, and body fat percentage. We found no significant change between soy protein supplementation and lean body mass, body mass, fat mass, and body fat percentage. Subgroup analysis for soy protein indicated there was a significant increase in lean body mass in individuals who supplemented for 12 or less weeks with soy protein (WMD: 1.48; 95% CI: 1.07, 1.89; P< 0.0001). Conclusion: Whey protein supplementation significantly improved body composition via increases in lean body mass, without influencing fat mass, body mass, and body fat percentage.

scholarly journals Associations Between Tenofovir Diphosphate in Dried Blood Spots, Impaired Physical Function, and Fracture Risk

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Mona Abdo ◽  
Ryan P Coyle ◽  
Sharon M Seifert ◽  
Jose R Castillo-Mancilla ◽  
Catherine M Jankowski ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Physical Function ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Dried Blood Spots ◽  
Blood Spots ◽  
Hip Bmd ◽  
Total Fat ◽  
Tenofovir Diphosphate

Abstract Background In this study, we evaluate associations between cumulative antiretroviral adherence/exposure, quantified using tenofovir diphosphate (TFV-DP) in dried blood spots (DBS), and human immunodeficiency virus (HIV)-related aging factors. Methods This is a cross-sectional analysis of younger (ages 18–35) and older (ages ≥60) persons with HIV (PWH) taking TFV disoproxil fumarate. Tenofovir diphosphate concentrations were quantified in DBS. Linear and logistic regression models were used to evaluate associations between TFV-DP and bone mineral density (BMD), physical function, frailty, and falls. Results Forty-five PWH were enrolled (23 younger, 22 older). Every 500 fmol/punch (equivalent to an increase in ~2 doses/week) increase in TFV-DP was associated with decreased hip BMD (−0.021 g/cm2; 95% confidence interval [CI], −0.040 to −0.002; P = .03). Adjusting for total fat mass, every 500 fmol/punch increase in TFV-DP was associated with higher odds of Short Physical Performance Battery impairment (score ≤10; adjusted odds ratio [OR], 1.6; 95% CI, 1.0–2.5; P = .04). Every 500 fmol/punch increase in TFV-DP was associated with slower 400-meter walk time (14.8 seconds; 95% CI, 3.8–25.8; P = .01) and remained significant after adjusting for age, lean body mass, body mass index (BMI), and fat mass (all P ≤ .01). Every 500 fmol/punch increase in TFV-DP was associated with higher odds of reporting a fall in the prior 6 months (OR, 1.8; 95% CI, 1.1–2.8; P = .02); this remained significant after adjusting for age, lean body mass, BMI, and total fat mass (all P &lt; .05). Conclusions Higher TFV-DP levels were associated with lower hip BMD, poorer physical function, and greater risk for falls, a concerning combination for increased fracture risk.

scholarly journals The Effects of Intermittent Fasting Combined with Resistance Training on Lean Body Mass: A Systematic Review of Human Studies

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2349
Author(s):  
Stephen Keenan ◽  
Matthew B. Cooke ◽  
Regina Belski
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Energy Restriction ◽  
Human Studies ◽  
Future Research ◽  
Intermittent Fasting ◽  
Eligibility Criteria

Diets utilising intermittent fasting (IF) as a strategic method to manipulate body composition have recently grown in popularity, however, dietary practices involving fasting have also been followed for centuries for religious reasons (i.e., Ramadan). Regardless of the reasons for engaging in IF, the impacts on lean body mass (LBM) may be detrimental. Previous research has demonstrated that resistance training promotes LBM accrual, however, whether this still occurs during IF is unclear. Therefore, the objective of this review is to systematically analyse human studies investigating the effects of variations of IF combined with resistance training on changes in LBM in previously sedentary or trained (non-elite) individuals. Changes in body weight and fat mass, and protocol adherence were assessed as a secondary objective. This review followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. MEDLINE, CINAHL, PubMed and SportDiscus databases were searched for articles investigating IF, combined with resistance training that reported measures of body composition. Eight studies met the eligibility criteria. LBM was generally maintained, while one study reported a significant increase in LBM. Body fat mass or percentage was significantly reduced in five of eight studies. Results suggest that IF paired with resistance training generally maintains LBM, and can also promote fat loss. Future research should examine longer-term effects of various forms of IF combined with resistance training compared to traditional forms of energy restriction. Prospero registration CRD42018103867.

scholarly journals Diet restriction and ageing in the dog: major observations over two decades

2007 ◽  
Vol 99 (4) ◽  
pp. 793-805 ◽  
Author(s):  
Dennis F. Lawler ◽  
Brian T. Larson ◽  
Joan M. Ballam ◽  
Gail K. Smith ◽  
Darryl N. Biery ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Energy Requirement ◽  
Diet Group ◽  
Metabolizable Energy ◽  
Skeletal Maturation ◽  
Pokeweed Mitogen ◽  
Diet Restriction ◽  
Cell Counts

This report reviews decade two of the lifetime diet restriction study of the dog. Labrador retrievers (n 48) were paired at age 6 weeks by sex and weight within each of seven litters, and assigned randomly within the pair to control-feeding (CF) or 25 % diet restriction (DR). Feeding began at age 8 weeks. The same diet was fed to all dogs; only the quantity differed. Major lifetime observations included 1·8 years longer median lifespan among diet-restricted dogs, with delayed onset of late life diseases, especially osteoarthritis. Long-term DR did not negatively affect skeletal maturation, structure or metabolism. Among all dogs, high static fat mass and declining lean body mass predicted death, most strongly at 1 year prior. Fat mass above 25 % was associated with increasing insulin resistance, which independently predicted lifespan and chronic diseases. Metabolizable energy requirement/lean body mass most accurately explained energy metabolism due to diet restriction; diet-restricted dogs required 17 % less energy to maintain each lean kilogram. Metabonomics-based urine metabolite trajectories reflected DR-related differences, suggesting that signals from gut microbiota may be involved in the DR longevity and health responses. Independent of feeding group, increased hazard of earlier death was associated with lower lymphoproliferative responses to phytohaemagglutinin, concanavalin A, and pokeweed mitogen; lower total lymphocytes, T-cells, CD4 and CD8 cells; lower CD8 percentages and higher B-cell percentages. When diet group was taken into account, PWM responses and cell counts and percentages remained predictive of earlier death.

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