scholarly journals Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns

2003 ◽  
Vol 94 (6) ◽  
pp. 2273-2281 ◽  
Author(s):  
Oscar E. Suman ◽  
Steve J. Thomas ◽  
Judy P. Wilkins ◽  
Ronald P. Mlcak ◽  
David N. Herndon
Keyword(s):  
Growth Hormone ◽  
Muscle Strength ◽  
Lean Body Mass ◽  
Body Mass ◽  
Recombinant Human Growth Hormone ◽  
Rehabilitation Program ◽  
Physical Rehabilitation ◽  
Percent Change ◽  
Home Based ◽  
The Mean

We tested the hypothesis that the administration of recombinant human growth hormone (rHGH) and exercise would increase lean body mass (LBM) and muscle strength in burned children to a greater extent than rHGH or exercise separately. Children, ages 7–17 yr, with >40% body surface area burned, were randomized into groups. One group (GHEX, n = 10) participated in a 12-wk in-hospital physical rehabilitation program supplemented with an exercise program and received 0.05 mg · kg−1· day−1of rHGH. A second exercising group (SALEX, n = 13) received saline. A third group (GH, n = 10) received a similar dose of rHGH as GHEX and participated in a 12-wk, home-based physical rehabilitation program without exercise. The fourth group (Saline, n = 11) received saline and participated in a 12-wk, home-based physical rehabilitation program without exercise. The mean (±SE) percent change in lean body mass after 12 wk was not significantly different between GHEX (9.0 ± 2.1%), SALEX (5.4 ± 1.6%), and GH (5.8 ± 1.8%) groups ( P = 0.33). However, the mean percent change in muscle strength was significantly greater in the GHEX (36.2 ± 5.4%) and SALEX (42.6 ± 10.0%) groups than in the GH (−7.4 ± 4.7%) or Saline (6.7 ± 4.4%) groups ( P = 0.008). In summary, rHGH GHEX, SALEX, and GH alone produced similar improvements in LBM. However, muscle strength was only increased via exercise.

Basal metabolic rate in adults with growth hormone deficiency and in patients with acromegaly: relationship with lean body mass, plasma insulin level and leucocyte sodium pump activity

1992 ◽  
Vol 83 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Franco Salomon ◽  
Ross C. Cuneo ◽  
Richard Hesp ◽  
Jenny F. Morris ◽  
Lucilla Poston ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Metabolic Rate ◽  
Growth Hormone Deficiency ◽  
Lean Body Mass ◽  
Body Mass ◽  
Basal Metabolic Rate ◽  
Plasma Insulin ◽  
Recombinant Human Growth Hormone ◽  
Hormone Deficiency ◽  
Sodium Efflux

1. The relationship of lean body mass, plasma insulin concentration and leucocyte active sodium transport with basal metabolic rate was investigated in 24 adults with growth hormone deficiency before and after treatment with recombinant human growth hormone and in 10 patients with untreated acromegaly. 2. Based on total-body potassium determined by whole-body 40K counting, patients with acromegaly had increased lean body mass, whereas lack of growth hormone was associated with decreased lean body mass. 3. By indirect calorimetry, patients with acromegaly had increased basal metabolic rates and patients with growth hormone deficiency had decreased values when expressed as percentages of values predicted from the WHO/FAO/UNU equations. Basal metabolic rate expressed in terms of lean body mass was similar in acromegaly and growth hormone deficiency, but was higher than normal in both patient groups. 4. The leucocyte ouabain-sensitive sodium efflux rate constant was decreased in both patients with acromegaly and patients with growth hormone deficiency, and there was no correlation with basal energy expenditure, fasting plasma insulin level or serum growth hormone level. 5. There was no increase in the sodium efflux rate constant in patients with growth hormone deficiency after 1 month on treatment with recombinant human growth hormone. 6. Apparent differences in basal metabolic rate in growth hormone deficiency and acromegaly are due to changes in lean body mass. Both adults with growth hormone deficiency and patients with acromegaly have increased energy expenditure, probably owing to changes in fuel metabolism which are not reflected in the leucocyte sodium pump activity.

Effects of a 12-wk resistance exercise program on skeletal muscle strength in children with burn injuries

2001 ◽  
Vol 91 (3) ◽  
pp. 1168-1175 ◽  
Author(s):  
Oscar E. Suman ◽  
Ricarda J. Spies ◽  
Mario M. Celis ◽  
Ronald P. Mlcak ◽  
David N. Herndon
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Resistance Exercise ◽  
Training Program ◽  
Lean Body Mass ◽  
Body Mass ◽  
Total Body Surface Area ◽  
Exercise Program ◽  
Rehabilitation Program ◽  
Leg Muscle

The posttraumatic response to burn injury leads to marked and prolonged skeletal muscle catabolism and weakness, which persist despite standard rehabilitation programs of occupational and physical therapy. We investigated whether a resistance exercise program would attenuate muscle loss and weakness that is typically found in children with thermal injury. We assessed the changes in leg muscle strength and lean body mass in severely burned children with >40% total body surface area burned. Patients were randomized to a 12-wk standard hospital rehabilitation program supplemented with an exercise training program ( n = 19) or to a home-based rehabilitation program without exercise ( n = 16). Leg muscle strength was assessed before and after the 12-wk rehabilitation or training program at an isokinetic speed of 150°/s. Lean body mass was assessed using dual-energy X-ray absorptiometry. We found that the participation in a resistance exercise program results in a significant improvement in muscle strength, power, and lean body mass relative to a standard rehabilitation program without exercise.

scholarly journals Asymmetry of muscle strength values during the basic period of rehabilitation after anterior cruciate ligament reconstruction in athletes

2021 ◽  
pp. 26-32
Author(s):  
О.V. Beziazychna ◽  
V.О. Litovchenko
Keyword(s):  
Muscle Strength ◽  
Cruciate Ligament ◽  
Rectus Femoris ◽  
Mean Amplitude ◽  
Rehabilitation Program ◽  
Asymmetry Index ◽  
Physical Rehabilitation ◽  
Basic Period ◽  
The Mean ◽  
Anterior Cruciate

Objective: to specify the features of muscle strength imbalance values as the criteria defining intensity and progress of rehabilitation after anterior cruciate ligament (ACL) reconstruction in athletes. The study involved 46 athletes having ACL injury. All the injured were young people under 44 years of age according to the current WHO classification. The control group, or experimental group consisted of 23 patients, and there were 25 patient s in the main one. Physical rehabilitation program for the patients of the CG and MG included therapeutic exercises, massage, and electrical myostimulation. Physical rehabilitation program for the MG patients was aimed at the priority recovery of tone, strength and mass of hamstrings. The article evaluates the effect of the developed physical rehabilitation program on the relation of strength values of the injured and intact limbs during the basic period of rehabilitation. The CG patients showed positive changes only according to EMG (asymmetry index of the mean amplitude of the rectus femoris and vastus medialis (р <0,05), and the MG patients significantly restored the balance between muscle strength values according to dynamometry results (moment of hip flexors and extensors strength, р<0,01; asymmetry index of hip flexors and extensors strength, р<0,05), and EMG (asymmetry index of the mean amplitude of the rectus femoris and vastus medialis, р<0,05). The study found that physical therapy program which additionally included electrical myostimulation and special exercises for hamstrings has significant effect on the relation of strength values of the injured and intact limbs during the basic period of rehabilitation.

scholarly journals GH Is Needed for the Maturation of Muscle Mass and Strength in Adolescents

2001 ◽  
Vol 86 (10) ◽  
pp. 4765-4770 ◽  
Author(s):  
Lena Hulthén ◽  
Bengt-Åke Bengtsson ◽  
Katharina Stibrant Sunnerhagen ◽  
Leif Hallberg ◽  
Gunnar Grimby ◽  
...  
Keyword(s):  
Young Adults ◽  
Muscle Strength ◽  
Lean Body Mass ◽  
Body Mass ◽  
Lean Mass ◽  
Gh Deficiency ◽  
Handgrip Strength ◽  
Adolescents And Young Adults ◽  
Gh Treatment ◽  
The Mean

The postpubertal period and the early years of adulthood may be of importance for continuing tissue maturation of importance in adulthood and aging. An example of this is the peak bone mass. This study has evaluated the importance of GH for lean mass and muscle strength in adolescents and young adults. GH treatment was discontinued in 40 adolescents aged 16–21 yr with GH deficiency of childhood onset. Measurements of isometric and isokinetic knee-extensor and flexor strength, handgrip strength, lean body mass, fat-free mass, and total body nitrogen were performed annually for 2 yr. Two hundred fifty healthy adolescents were randomly selected for prospective measurements of lean mass and handgrip strength between the ages of 17 and 21 yr. In the adolescents with continuing GH deficiency, lean body mass decreased, compared with the patients defined as having sufficient endogenous GH. The isometric strength in knee flexors increased in the sufficient endogenous GH group and was unchanged in the GH deficiency group during the 2 yr off GH treatment (between group, P &lt; 0.05). The mean and peak handgrip strength increased on average by 9–15% in the group with sufficient endogenous GH and was unchanged in those with GH deficiency (P&lt; 0.05). Lean body mass and handgrip strength (both, P &lt; 0.001) increased in both the healthy boys and girls who were followed for 4 yr with a more marked increase in the boys. The mean increase in handgrip between the age of 17 and 21 yr was 7–9%. The increased lean mass and improved muscle performance seen in healthy adolescents did not occur in adolescents with GH deficiency. These findings suggest that GH is of importance for the maturation of lean mass and muscle strength in adolescents and young adults.

The Role of Lean Body Mass as a Nutritional Index in Chinese Peritoneal Dialysis Patients—Comparison of Creatinine Kinetics Method and Anthropometric Method

2000 ◽  
Vol 20 (6) ◽  
pp. 708-714 ◽  
Author(s):  
Cheuk-Chun Szeto ◽  
Johnathan Kong ◽  
Alan K.L. Wu ◽  
Teresa Y.H. Wong ◽  
Angela Y.M. Wang ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Serum Albumin ◽  
Lean Body Mass ◽  
Body Mass ◽  
Chinese Patients ◽  
Nutritional Indices ◽  
Protein Nitrogen ◽  
Creatinine Kinetics ◽  
The Mean ◽  
The Difference

Objective To compare, in Chinese continuous ambulatory peritoneal dialysis (CAPD) patients, the creatinine kinetics method (LBM-CK) and the anthropometric method (LBM-AM) for determining lean body mass (LBM). Design Single-center cross-sectional study. Patients and Methods We studied 151 unselected CAPD patients (78 males, 73 females). We calculated LBM-CK and LBM-AM using standard formulas. The results of the two methods were then compared by the Bland and Altman method. Dialysis adequacy and other nutritional indices, including total Kt/V, weekly creatinine clearance (CCr), residual glomerular filtration rate (GFR), protein nitrogen appearance (PNA), subjective global assessment (SGA), and serum albumin, were measured simultaneously. Results The mean age of the patients was 55.6 ± 12.2 years, and the mean duration of dialysis was 33.6 ± 28.5 months. The mean body mass index (BMI) was 22.7 ± 3.7. The average LBM-AM was 43.6 ± 8.0 kg; the average LBM-CK was 33.0 ± 9.3 kg. The difference between the calculated LBM-AM and LBM-CK was 10.7 kg, with LBM-AM always giving a higher value; the limits of agreement were –5.8 kg and 27.1 kg. The difference between the two measures correlated with residual GFR (Pearson r = 0.629, p < 0.001). After normalizing for desired body weight, LBM-AM was only modestly correlated with serum albumin level. No correlations were found between overall SGA score or normalized protein nitrogen appearance (nPNA) and LBM-AM or LBM-CK. Conclusions In Chinese patients at least, a substantial discrepancy exists between LBM-AM and LBM-CK. The difference is especially marked in patients with significant residual renal function. The optimal method for determining LBM remains obscure in Chinese CAPD patients. Moreover, LBM correlated poorly with other nutritional indices. Multiple parameters should be taken into consideration in an assessment of nutritional status of CAPD patients.

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