Role of Nitric Oxide in the Early Renal Changes Induced by High Fructose Diet in Rats

2002 ◽  
Vol 25 (6) ◽  
pp. 363-369 ◽  
Author(s):  
Alessandro Cosenzi ◽  
Elena Bernobich ◽  
Michela Bonavita ◽  
Furio Gris ◽  
Giulio Odoni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
High Fructose Diet ◽  
High Fructose ◽  
Renal Changes

scholarly journals Influence of Normo- and Hypogonadal Condition, Hyperuricemia, and High-Fructose Diet on Renal Changes in Male Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jimena Soutelo ◽  
Yanina Alejandra Samaniego ◽  
Elsa Zotta ◽  
María Cecilia Fornari ◽  
Carlos Reyes Toso ◽  
...  
Keyword(s):  
Gender Disparity ◽  
Male Rats ◽  
Renal Lesion ◽  
Treatment Control ◽  
High Fructose Diet ◽  
High Fructose ◽  
Renal Changes ◽  
Male Wistar Rats ◽  
Progression Of Renal Disease ◽  
Oxonic Acid

Background. There is a gender disparity in the incidence, prevalence, and progression of renal disease. The object of this paper is to evaluate the presence and type of renal lesion in normogonadic and hypogonadic male rats in a mild hyperuricemia induced condition and exposed to a high-fructose diet. Methods. 56 adult male Wistar rats were used. Animals were divided into two groups, one normogonadic (NGN) and one hypogonadic (HGN), and each group was divided into four subgroups in accordance with the treatment: control with only water (C), fructose (F), oxonic acid (OA), and fructose + oxonic acid (FOA). Renal changes were evaluated by measuring glomerulosclerosis, fibrosis, and arteriolar media/lumen (M/L) ratio.Results. The OA and FOA groups presented significantly hypertension (p<0.001). The OA group significantly increased (p<0.05) the percentage of glomerulosclerosis as well as the FOA group (p<0.001). When comparing NGN versus HGN, we observed a trend to a lower glomerulosclerosis in the latter. A higher arteriolar M/L ratio was observed in the OA (p<0.05) and FOA (p<0.001). Conclusion. Hyperuricemia conditions and a high-fructose diet favor blood pressure increase together with changes in the arteriolar media/lumen ratio and renal glomerular damage. These changes were more apparent in normogonadic animals.

Role of high-fructose diet in experimental induction of nonalcoholic steatohepatitis in rats

2017 ◽  
Vol 45 (3) ◽  
pp. 141
Author(s):  
AssmaaM.F. Abdel-Aziz El Sheikh ◽  
SobhyA El-Hamid Hassan ◽  
ManalM El-Batch ◽  
SohaS Zakareia
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
High Fructose Diet ◽  
Experimental Induction ◽  
High Fructose

Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet

2007 ◽  
Vol 293 (2) ◽  
pp. H1083-H1089 ◽  
Author(s):  
Vera Farah ◽  
Khalid M. Elased ◽  
Mariana Morris
Keyword(s):  
Blood Pressure ◽  
Glucose Tolerance ◽  
Arterial Pressure ◽  
Pulse Interval ◽  
Standard Diet ◽  
Dark Phase ◽  
Adrenergic Blockade ◽  
High Fructose Diet ◽  
High Fructose

The renin-angiotensin system (RAS) has been implicated in the cardiovascular complications of diabetes. We showed that a high-fructose diet increases blood pressure and plasma angiotensin and impairs glucose tolerance. We investigated the role of angiotensin AT1a receptors in the development of fructose-induced cardiovascular and metabolic dysfunction. Male angiotensin AT1a knockout (AT1aKO) and wild-type (AT1aWT) mice with arterial telemetric catheters were fed a standard diet or one containing 60% fructose. Fructose increased mean arterial pressure (MAP) in AT1aWT but only during the dark phase (8% increase). In AT1aKO mice, fructose unexpectedly decreased MAP, during both light and dark periods (24 and 13% decrease, respectively). Analytical methods were used to measure systolic arterial pressure (SAP) and pulse interval (PI) variability in time and frequency domains. In fructose-fed AT1aWT mice, there was an increase in SAP variance and its low-frequency (LF) domain (11 ± 3 vs. 23 ± 4 mmHg2, variance, and 7 ± 2 vs. 17 ± 3 mmHg2, LF, control vs. fructose, P < 0.004). There were no changes in SAP variance in AT1aKO mice. Depressor responses to α1-adrenergic blockade were augmented in fructose-fed AT1a WT compared with AT1aKO mice. Fructose inhibited glucose tolerance with a greater effect in AT1aWT mice. Fructose increased plasma cholesterol in both groups ( P < 0.01) and reduced ANG II in AT1aKO mice. Results document prominent interactions between genetics and diet with data showing that in the absence of angiotensin AT1a receptors, a fructose diet decreased blood pressure.

Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome

2008 ◽  
Vol 294 (4) ◽  
pp. F710-F718 ◽  
Author(s):  
Laura G. Sánchez-Lozada ◽  
Edilia Tapia ◽  
Pablo Bautista-García ◽  
Virgilia Soto ◽  
Carmen Ávila-Casado ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Oxidase Inhibitor ◽  
Normal Diet ◽  
Xanthine Oxidase Inhibitor ◽  
Morphological Alterations ◽  
Renal Vasoconstriction ◽  
High Fructose Diet ◽  
High Fructose

Increased fructose consumption is associated with hyperuricemia, metabolic syndrome, and renal damage. This study evaluated whether febuxostat (Fx), an investigational nonpurine, and selective xanthine oxidase inhibitor, could alleviate the features of metabolic syndrome as well as the renal hemodynamic alterations and afferent arteriolopathy induced by a high-fructose diet in rats. Two groups of rats were fed a high-fructose diet (60% fructose) for 8 wk, and two groups received a normal diet. For each diet, one group was treated with Fx (5–6 mg·kg−1·day−1 in the drinking water) during the last 4 wk (i.e., after the onset of metabolic syndrome), and the other received no treatment (placebo; P). Body weight was measured daily. Systolic blood pressure and fasting plasma uric acid (UA), insulin, and triglycerides were measured at baseline and at 4 and 8 wk. Renal hemodynamics and histomorphology were evaluated at the end of the study. A high-fructose diet was associated with hyperuricemia, hypertension, as well as increased plasma triglycerides and insulin. Compared with fructose+P, fructose+Fx rats showed significantly lowered blood pressure, UA, triglycerides, and insulin ( P < 0.05 for all comparisons). Moreover, fructose+Fx rats had significantly reduced glomerular pressure, renal vasoconstriction, and afferent arteriolar area relative to fructose+P rats. Fx treatment in rats on a normal diet had no significant effects. In conclusion, normalization of plasma UA with Fx in rats with metabolic syndrome alleviated both metabolic and glomerular hemodynamic and morphological alterations. These results provide further evidence for a pathogenic role of hyperuricemia in fructose-mediated metabolic syndrome.

scholarly journals Peculiarities of Metabolism of Rats with Fructose-induced Insulin Resistance Against the Background of Congenital and Acquired Iodine Deficiency

2019 ◽  
Vol 26 (4) ◽  
Author(s):  
Vasyl Stetseviat
Keyword(s):  
Insulin Resistance ◽  
Carbohydrate Metabolism ◽  
Iodine Deficiency ◽  
Total Cholesterol Level ◽  
Glycosylated Hemoglobin ◽  
High Density Lipoproteins ◽  
High Fructose Diet ◽  
High Fructose ◽  
Increased Risk

Animals following a high-fructose diet during eight weeks, have experienced changes in metabolism and the signs of insulin resistance have developed. Under such conditions, moderate hyperglycemia, hyperinsulinemia, hyperuricemia, an increase of the level of glycosylated hemoglobin in whole blood were observed. The significant role of the HOMA-IR index, as an early marker of carbohydrate metabolism disorders at the stage of pre-diabetes, has been confirmed. In experimental animals against the background of the high-fructose diet, the changes in the lipid spectrum of the blood were revealed: an increase of the total cholesterol level, low-density lipoproteins, triglycerides against the background of a high-density lipoproteins decrease. These disorders and a significant increase of the atherogenicity reflect the development of secondary dyslipidemia. In this case, the disorders of carbohydrate metabolism were combined with the degree of dyslipidemia. Males were found to have at increased risk of development the insulin resistance and comorbid pathology. Iodine deficiency, especially of congenital nature, is an aggravating factor of metabolic disorders. The obtained data can serve as a basis for extend of preventive measures and identification of the priority treatment schemes for type 2 diabetes mellitus in residents of endemic regions.

scholarly journals Effects of Dietary Brown Rice on Carcass Composition and Nitric Oxide (NOx) Metabolite Levels in High-Fat High-Fructose Diet-induced Sprague Dawley Rats as Obesity Model

2020 ◽  
Vol 1665 ◽  
pp. 012007
Author(s):  
Dian Handayani ◽  
Ahmad Ramadhan ◽  
Risma Debby Anindyanti ◽  
Alma Maghfirotun Innayah ◽  
Etik Sulistyowati ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Brown Rice ◽  
Carcass Composition ◽  
Sprague Dawley ◽  
High Fat ◽  
High Fructose Diet ◽  
Sprague Dawley Rats ◽  
High Fructose

scholarly journals Role of AMPD2 in impaired glucose tolerance induced by high fructose diet

2017 ◽  
Vol 13 ◽  
pp. 23-29 ◽  
Author(s):  
Athanasius Wrin Hudoyo ◽  
Tetsuaki Hirase ◽  
Andreas Tandelillin ◽  
Masahiko Honda ◽  
Manabu Shirai ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
High Fructose Diet ◽  
High Fructose

scholarly journals Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet

2015 ◽  
Vol 48 (1) ◽  
Author(s):  
Romina Hernández-Salinas ◽  
Valerie Decap ◽  
Alberto Leguina ◽  
Patricio Cáceres ◽  
Druso Perez ◽  
...  
Keyword(s):  
Wine Grape ◽  
High Fructose Diet ◽  
High Fructose
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