PSA Decline Is an Independent Prognostic Marker in Hormonally Treated Prostate Cancer

1999 ◽  
Vol 36 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Christian Palmberg ◽  
Pasi Koivisto ◽  
Tapio Visakorpi ◽  
Teuvo L.J. Tammela
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Independent Prognostic Marker

scholarly journals Upregulation of microRNA-191 can serve as an independent prognostic marker for poor survival in prostate cancer

Medicine ◽  
2019 ◽  
Vol 98 (29) ◽  
pp. e16193 ◽  
Author(s):  
Jing-bo Liu ◽  
Yong-ji Yan ◽  
Jing Shi ◽  
Ya-bing Wu ◽  
Yan-feng Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Poor Survival ◽  
Independent Prognostic Marker

Molecular Load of Pathologically Occult Metastases in Pelvic Lymph Nodes Is an Independent Prognostic Marker of Biochemical Failure After Localized Prostate Cancer Treatment

2006 ◽  
Vol 24 (19) ◽  
pp. 3081-3088 ◽  
Author(s):  
Anna C. Ferrari ◽  
Nelson N. Stone ◽  
Ralf Kurek ◽  
Elizabeth Mulligan ◽  
Roy McGregor ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Lymph Nodes ◽  
Prognostic Marker ◽  
Risk Group ◽  
High Risk Group ◽  
Biochemical Failure ◽  
Localized Prostate Cancer ◽  
Pelvic Lymph Nodes ◽  
Independent Prognostic Marker

Purpose Thirty percent of patients treated with curative intent for localized prostate cancer (PC) experience biochemical recurrence (BCR) with rising serum prostate-specific antigen (sPSA), and of these, approximately 50% succumb to progressive disease. More discriminatory staging procedures are needed to identify occult micrometastases that spawn BCR. Patients and Methods PSA mRNA copies in pathologically normal pelvic lymph nodes (N0-PLN) from 341 localized PC patients were quantified by real-time reverse-transcriptase polymerase chain reaction. Based on comparisons with normal lymph nodes and PLN with metastases and on normalization to 5 × 106 glyceraldehyde-3′-phosphate dehydrogenase mRNA copies, normalized PSA copies (PSA-N) and a threshold of PSA-N 100 or more were selected for continuous and categorical multivariate analyses of biochemical failure-free survival (BFFS) compared with established risk factors. Results At median follow-up of 4 years, the BFFS of patients with PSA-N 100 or more versus PSA-N less than 100 was 55% and 77% (P = .0002), respectively. The effect was greatest for sPSA greater than 20 ng/mL, 25% versus 60% (P = .014), Gleason score 8 or higher, 21% versus 66% (P = .0002), stage T3c, 18% versus 64% (P = .001), and high-risk group (50% v 72%; P = .05). By continuous analysis PSA-N was an independent prognostic marker for BCR (P = .049) with a hazard ratio of 1.25 (95% CI, 1.001 to 1.57). By categorical analysis, PSA-N 100 or more was an independent variable (P = .021) with a relative risk of 1.98 (95% CI, 1.11 to 3.55) for BCR compared with PSA-N less than 100. Conclusion PSA-N 100 or more is a new, independent molecular staging criterion for localized PC that identifies high-risk group patients with clinically relevant occult micrometastases in N0-PLN, who may benefit from additional therapy to prevent BCR.

ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer

2008 ◽  
Vol 54 (5) ◽  
pp. 1097-1108 ◽  
Author(s):  
Florian R. Fritzsche ◽  
Monika Jung ◽  
Angelika Tölle ◽  
Peter Wild ◽  
Arndt Hartmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Independent Prognostic Marker ◽  
Psa Relapse

High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions

2014 ◽  
Vol 50 (4) ◽  
pp. 852-861 ◽  
Author(s):  
Katharina Grupp ◽  
Julia Wilking ◽  
Kristina Prien ◽  
Claudia Hube-Magg ◽  
Hüseyin Sirma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Rna Binding ◽  
Binding Motif ◽  
Independent Prognostic Marker

scholarly journals Correction: Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (2) ◽  
pp. 3761-3761
Author(s):  
Martina Kluth ◽  
Ramin Ahrary ◽  
Claudia Hube-Magg ◽  
Malik Ahmed ◽  
Heinke Volta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Genomic Deletion ◽  
Independent Prognostic Marker ◽  
Chromosome 12P
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