The Enzymatic Basis for the Conversion of Nonfucosylated to Fucosylated α-Fetoprotein by Acyclic Retinoid Treatment in Human Hepatoma Cells: Activation of α1-6 Fucosyltransferase

Tumor Biology ◽  
2002 ◽  
Vol 23 (4) ◽  
pp. 202-211 ◽  
Author(s):  
Katsuhisa Noda ◽  
Eiji Miyoshi ◽  
Takatoshi Kitada ◽  
Susumu Nakahara ◽  
Cong-Xiao Gao ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Alpha Fetoprotein ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Acyclic Retinoid ◽  
Retinoid Treatment

The role of alpha-fetoprotein in maintaining the growth of human hepatoma cells

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14081-14081
Author(s):  
M. Li ◽  
S. Zhou ◽  
X. Liu ◽  
G. Li
Keyword(s):  
Confocal Microscopy ◽  
Caspase 3 ◽  
Immune Surveillance ◽  
Hepatoma Cells ◽  
Alpha Fetoprotein ◽  
Jurkat Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Apoptosis Related Gene

14081 Background: This study was to explored the functional mechanism of alpha-fetoprotein (AFP) in maintaining the proliferation of human hepatoma cells line Bel 7402 and the immunsuppression of lymphocyte Jurkat cells. Methods: Western blot was used to detecting the expression of some apoptosis-related gene, fluorescence labeled AFP and confocal microscopy scanning for receptor binding assay in the membrane in Jurkat cells. Results: It showed that AFP could enhance the expression of survivin and c-ras, but restrain caspase-3 express in Bel 7402 cells by Western blotting analysis. It also showed that AFP could bind to the membrane of Jurkat cells by confocal microscopy scanning, and when treated Jurkat with AFP, it indicated that AFP could repress the expression of survivin and Livin and elevated the activity of caspase-3 in the cells; Co-cultured Bel 7402 cells with Jurkat cells, the expression of tumor necrosis related-apoptosis induced ligand (TRAIL) in Jurkt cells was inhibited, when pretreatment with monoclonal antibody of AFP (Anti-AFP), the restrained effect of TRAIL express and the activity of caspase-3 was elevated in Jurkat cells was removed. It also indicated that Anti-AFP had an ability to block these functions of AFP. Conclusions: AFP has a capability to promote the growth and escape from immune surveillance of human hepatoma cells through enhancing the expression of ras and survivin gene in Bel 7402 cells, suppressing TRAIL, survivin and Livin expressed and upregulated activity of caspase-3 in Jurkat cells. No significant financial relationships to disclose.

scholarly journals Synergistic Effects of Acyclic Retinoid and OSI-461 on Growth Inhibition and Gene Expression in Human Hepatoma Cells

2004 ◽  
Vol 10 (19) ◽  
pp. 6710-6721 ◽  
Author(s):  
Masahito Shimizu ◽  
Masumi Suzui ◽  
Atsuko Deguchi ◽  
Jin T. E. Lim ◽  
Danhua Xiao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Inhibition ◽  
Synergistic Effects ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Acyclic Retinoid

900 Acyclic retinoid inhibits the growth of human hepatoma cells by suppressing FGF signaling pathways

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 592-593
Author(s):  
R SHAO ◽  
M OTSUKA ◽  
N KATO ◽  
H TANIGUCHI ◽  
Y HOSHIDA ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Fgf Signaling ◽  
Human Hepatoma Cells ◽  
Acyclic Retinoid

Induction of Apoptosis in Human Hepatoma Cells by Alpha-Fetoprotein

Tumor Biology ◽  
1997 ◽  
Vol 18 (5) ◽  
pp. 261-273 ◽  
Author(s):  
Lydia N. Semenkova ◽  
Elena I. Dudich ◽  
Igor V. Dudich
Keyword(s):  
Hepatoma Cells ◽  
Alpha Fetoprotein ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Induction Of Apoptosis

Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice

2012 ◽  
Vol 42 (12) ◽  
pp. 1241-1247 ◽  
Author(s):  
Masahito Shimizu ◽  
Yohei Shirakami ◽  
Hiroyasu Sakai ◽  
Junpei Iwasa ◽  
Makoto Shiraki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Nude Mice ◽  
Branched Chain Amino Acids ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Xenograft Growth ◽  
Acyclic Retinoid ◽  
Branched Chain

scholarly journals Inhibitory effect of composite Gan’aining on growth and alpha-fetoprotein secretion of human hepatoma cells

2006 ◽  
Vol 14 (19) ◽  
pp. 1912
Author(s):  
Dong-Sheng Yuan ◽  
Xin-Hua Wang ◽  
Dong-Hui Liu ◽  
Cai-Ping Zhu ◽  
Lei Shi
Keyword(s):  
Inhibitory Effect ◽  
Hepatoma Cells ◽  
Alpha Fetoprotein ◽  
Human Hepatoma ◽  
Human Hepatoma Cells
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