Mechanisms and Management of Weight Gain Associated with Drug Treatment of Affective Disorders

Author(s):  
U. Zimmermann ◽  
T. Kraus ◽  
T. Pollm�cher
1959 ◽  
Vol 105 (441) ◽  
pp. 1123-1126 ◽  
Author(s):  
J. T. Leyberg ◽  
J. C. Denmark

Drug treatment of depressive states has hitherto been somewhat disappointing but recent reports by Kuhn (1957, 1958), Kielholz and Battegay (1958) from Switzerland, and Azimo and Vispo (1958) from Canada have claimed that imipramine hydrochloride (Tofranil) has “thymoleptic” qualities and is of specific therapeutic value in states of endogenous depression and allied affective disorders.


1972 ◽  
Vol 2 (3) ◽  
pp. 232-238 ◽  
Author(s):  
Tom G. Bolwig ◽  
Ole J. Rafaelsen

SynopsisSpontaneous and metacholine-stimulated salivation rates were measured in endogenous depression, symptomatic depression, mania, and healthy controls. In manic-depressive patients concentrations of salivary electrolytes were measured. Salivation rates were decreased in untreated endogenous depression and mania. After remission by ECT but not by drug treatment flow rates increased towards normal values. Estimations of electrolytes revealed no specific pattern of excretion in manic-depressive patients.


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