Chapter 4: Requirements Concerning Antiseptics for Periorbital, Orbital and Intraorbital Application. 4.4.: Pharmacokinetics of Ophthalmic Drugs

Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Polymers ◽

10.3390/polym13071102 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1102

Author(s):

Paola Franco ◽

Iolanda De Marco

Keyword(s):

Contact Lenses ◽

Pharmacological Action ◽

Active Principle ◽

Prolonged Release ◽

Eye Drops ◽

Polymeric Support ◽

Physiological Factors ◽

Ophthalmic Drugs ◽

Innovative Methods ◽

Ophthalmic Drug

Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of ophthalmic drugs into contact lenses can be performed by different techniques; nowadays, the soaking method is mainly employed. To improve the therapeutic performance of drug-loaded contact lenses, innovative methods have recently been proposed, including the impregnation with supercritical carbon dioxide. This updated review of therapeutic contact lenses production and application provides useful information on the most effective preparation methodologies, recent achievements and future perspectives.

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Topical Delivery System of Ophthalmic Drugs by Periocular Injection with Viscous Solution.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.22.961 ◽

1999 ◽

Vol 22 (9) ◽

pp. 961-965 ◽

Cited By ~ 5

Author(s):

Hitoshi SASAKI ◽

Satsuki KASHIWAGI ◽

Takahiro MUKAI ◽

Koyo NISHIDA ◽

Junzo NAKAMURA ◽

...

Keyword(s):

Delivery System ◽

Topical Delivery ◽

Ophthalmic Drugs ◽

Viscous Solution

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PSS21 An Analysis of the Health-State Utilities of Economic Studies Evaluating Ophthalmic Drugs: A Systematic Review

Value in Health ◽

10.1016/j.jval.2020.08.1983 ◽

2020 ◽

Vol 23 ◽

pp. S737

Author(s):

I. Ribeiro ◽

F. Batel Marques ◽

D. Mendes ◽

C. Alves

Keyword(s):

Systematic Review ◽

Health State ◽

Ophthalmic Drugs ◽

Health State Utilities ◽

Economic Studies

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Pharmacoeconomical approaches for assessing the rational use of ophthalmic drugs in polyclinic settings

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-2-143-145 ◽

2021 ◽

pp. 143-145

Author(s):

N.A. Nefedov ◽

◽

D.S. Ramonas ◽

B.G. Khasanov ◽

A.S. Alexandrov ◽

...

Keyword(s):

Fold Increase ◽

Eye Drops ◽

Ophthalmic Drugs ◽

Rational Use ◽

Rational Drug ◽

Acquisition Costs ◽

The Cost ◽

Drug Provision ◽

Combined Drugs

Purpose. To evaluate the results of the rational use of ophthalmic medicines with the use of pharmacoeconomical analysis. Material and methods. With the help of ABC-VEN analysis, a comparative study of the quality of pharmacotherapy and drug provision of patients who were monitored and treated by an ophthalmologist of the polyclinic in 2015 and 2019 was conducted. Results. As a result, it was found that the share of costs for vital drugs increased by 10.1% and amounted to 71.1% in 2019, which corresponds to the standardized criterion (70-80%). There was a reduction in the cost of purchasing secondary drugs by 7.6%, which indicates a rational drug supply of ophthalmic drugs. The most commonly used drugs for the treatment of glaucoma were 27.8% in 2015 and 35.1% in 2019. The share of their acquisition costs was 54.9% and 67.9%, respectively. There was a significant increase in the range and number of drugs for the treatment of patients with glaucoma: a 2.8-fold increase in the number of purchased eye drops for monotherapy and a 12% increase in the number of combined drugs. Conclusion. Pharmacoeconomical analysis showed an optimization of spending money on the purchase of drugs used in ophthalmology: an increase of 10.1% in the share of vital drugs and a decrease of 7.6% in the cost of purchasing secondary drugs. There was an increase in the range and quantity of drugs for the treatment of patients with glaucoma. Key words: ABC-VEN-analysis, drugs, ophthalmology, pharmacoeconomics.

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