Dose-Response Effect of Egg-Phosphatidylcholine on Maze-Learning Ability and Fatty Acid Composition of Plasma and Brain in Aged Mice Fed an n–3 Fatty Acid-Deficient Diet

2002 ◽  
Vol 46 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Sun-Young Lim ◽  
Hiramitsu Suzuki
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Dose Response ◽  
Maze Learning ◽  
Learning Ability ◽  
Deficient Diet ◽  
Response Effect ◽  
Aged Mice ◽  
Dose Response Effect

Dose-Response Effect of Docosahexaenoic Acid Ethyl Ester on Maze Behavior and Brain Fatty Acid Composition in Adult Mice

2002 ◽  
Vol 72 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Sun-Young Lim ◽  
Hiramitsu Suzuki
Keyword(s):  
Docosahexaenoic Acid ◽  
Ethyl Ester ◽  
Palm Oil ◽  
Dose Response ◽  
Maze Learning ◽  
Learning Ability ◽  
Control Group ◽  
Response Effect ◽  
Adult Mice ◽  
Dose Response Effect

The dose-response effect of dietary docosahexaenoic acid (DHA, 22:6 n-3) ethyl ester (EE) on maze-learning ability in mice was studied. Male Crj:CD-1 mice aged three months were fed a) a diet containing 5 g palm oil/100 g diet (control group); b) a diet containing 0.5 g DHA ethyl ester/100 g diet plus 4.5 g palm oil/100g diet (DHA-EE 0.5% group); c) a diet containing 1g DHA ethyl ester/100 g diet plus 4g palm oil/100 g diet (DHA-EE 1% group); d) a diet containing 2 g DHA ethyl ester/100 g diet plus 3 g palm oil/100 g diet (DHA-EE 2% group) for four months. Maze-learning ability was assessed three months after the start of the experiment. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured in three trials, performed every four days. In trial 1, the DHA-EE 0.5%, 1% and 2% groups required less (p < 0.05) time to reach the maze exit, and the DHA-EE 2% group strayed (p < 0.05) into blind alleys fewer times than the control group. In trial 3 performed four days after the second trial, the DHA-EE 2% group needed less (p < 0.05) time to find the exit and spent a fewer (p < 0.05) number of times in blind alleys than did the control group. In the total lipids of plasma and brain of mice fed DHA, increasing intakes of DHA resulted in an increase in DHA levels, with a corresponding decrease in arachidonic acid (20:4 n-6). Improved maze-learning ability in mice fed DHA-EE 2% was associated with higher DHA levels in brain. Our results suggest that there are no linear dose-response effects of DHA on maze-learning ability, however, the intake of DHA-EE 2% diet improves learning ability in adult mice as demonstrated by maze performance.

Effect of Dietary Docosahexaenoic Acid and Phosphatidylcholine on Maze Behavior and Fatty Acid Composition of Plasma and Brain Lipids in Mice

2000 ◽  
Vol 70 (5) ◽  
pp. 251-259 ◽  
Author(s):  
Sun-Young Lim ◽  
Hiramitsu Suzuki
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Palm Oil ◽  
Maze Learning ◽  
Learning Ability ◽  
Control Group ◽  
Dietary Docosahexaenoic Acid ◽  
Group 5

We investigated the effects of dietary docosahexaenoic acid (DHA, 22:6 n-3) and phosphatidylcholine (PC) on maze behavior and brain fatty acids in mice. Male Crj:CD-1 mice (3 wk old) were fed a diet containing 2% DHA and 3% palm oil (DHA group); 5% PC (PC group); 1% DHA, 2.5% PC and 1.5% palm oil (DHA+PC group); 5% palm oil (Palm oil control group) or MF laboratory chow (MF control group) for 7 mo. After this time maze-learning ability was assessed. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured three times every four days. After the last learning test, all mice were sacrificed and plasma and brain were analyzed for fatty acid composition. The DHA and PC groups required less time to reach the maze exit and strayed less into blind alleys than the control group in the third trial. The difference between the DHA or PC groups and control mice was statistically significant (p < 0.05). In the total lipids of plasma and brain of mice fed DHA, there was a significant increase in DHA levels and a concomitant decrease in arachidonic acid (AA, 20:4 n-6). Similar changes in fatty acid composition were observed in brain phosphatidylcholine and phosphatidylethanolamine for this group of mice. However, this pattern of changes in brain fatty acids was not evident in the PC group. Our data suggest that maze-learning ability in mice is enhanced by intakes of DHA and PC. However, the mechanisms by which the DHA and PC diets improved learning ability appear to be different. A synergistic effect of DHA and PC on learning ability is not apparent in the DHA+PC group.

Effect of a Vitamin B-12-Deficient Diet on Lipid and Fatty Acid Composition of Spinal Cord Myelin in the Fruit Bat

1983 ◽  
Vol 113 (3) ◽  
pp. 531-537 ◽  
Author(s):  
Justin van der Westhuyzen ◽  
Richard C. Cantrill ◽  
Francisco Fernandes-Costa ◽  
Jack Metz
Keyword(s):  
Spinal Cord ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Vitamin B ◽  
Deficient Diet ◽  
Fruit Bat ◽  
Vitamin B 12

Influence of a long-term zinc-deficient diet on rat platelet function and fatty acid composition

BioMetals ◽  
1995 ◽  
Vol 8 (1) ◽  
Author(s):  
Patrice Faure ◽  
Philippe Durand ◽  
Denis Blache ◽  
Alain Favier ◽  
AnneMarie Roussel
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Platelet Function ◽  
Deficient Diet ◽  
Zinc Deficient Diet

scholarly journals Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

Diabetes ◽  
2005 ◽  
Vol 54 (6) ◽  
pp. 1640-1648 ◽  
Author(s):  
R. Belfort ◽  
L. Mandarino ◽  
S. Kashyap ◽  
K. Wirfel ◽  
T. Pratipanawatr ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Dose Response ◽  
Insulin Signaling ◽  
Plasma Free Fatty Acid ◽  
Elevated Plasma ◽  
Response Effect ◽  
Dose Response Effect

scholarly journals The Effects of α-Lipoic Acid on Liver Oxidative Stress and Free Fatty Acid Composition in Methionine–Choline Deficient Diet-Induced NAFLD

2014 ◽  
Vol 17 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Milena N. Stanković ◽  
Dušan Mladenović ◽  
Milica Ninković ◽  
Ivana Ðuričić ◽  
Slađana Šobajić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Acid Composition ◽  
Lipoic Acid ◽  
Deficient Diet

Effect of Isoprenaline on Salivary Gland Lipids of Rats Fed a Choline-Deficient Diet

1978 ◽  
Vol 57 (4) ◽  
pp. 643-649 ◽  
Author(s):  
Syed Q. Alam ◽  
Bassima S. Alam
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Phosphatidyl Ethanolamine ◽  
Control Diet ◽  
Deficient Diet ◽  
Adult Rats ◽  
Male Adult ◽  
Submandibular Salivary Glands ◽  
Deficient Group

Male adult rats were fed choline deficient and a choline-supplemented diet for 3 weeks. Half the rats from each group were injected with isoprenaline (16 mg/kg body wt.) and the remainder with saline. After 2 and 8 hours, rats were sacrificed, their submandibular salivary glands (SMSG) were disected out, and extracted for lipids. The fatty acid composition of total lipids and some neutral and phospholipid fractions were determined. Isoprenaline administration resulted in a slightly higher level of oleic acid in SMSG of rats fed choline-deficient but not the control diet. There was an increase in the free fatty acid (FFA) concentrations of the gland after 2 hours of isoprenaline treatment in rats fed the control diet; no such increase was observed in the choline-deficient group. The fatty acid composition of the FFA fraction was also slightly changed as a result of isoprenaline treatment, but only in the choline-deficient group. The fatty acid composition of triglyceride (TG), phosphatidyl choline (PC), and phosphatidyl ethanolamine (PE) fractions was not changed.

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