Aging and Salivary Cytokine Concentrations as Predictors of Whole Saliva Flow Rates among Women

Gerontology ◽  
2002 ◽  
Vol 48 (5) ◽  
pp. 282-288 ◽  
Author(s):  
Charles Streckfus ◽  
Lenora Bigler ◽  
Tanya O’Bryan
Keyword(s):  
Flow Rates ◽  
Whole Saliva ◽  
Saliva Flow

Electrical Stimulation of Salivary Flow in Patients with Sjögren's Syndrome

1988 ◽  
Vol 67 (10) ◽  
pp. 1334-1337 ◽  
Author(s):  
M. Steller ◽  
L. Chou ◽  
T.E. Daniels
Keyword(s):  
Electrical Stimulation ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Salivary Flow ◽  
Sjogren's Syndrome ◽  
Flow Rates ◽  
Active Devices ◽  
Whole Saliva ◽  
Saliva Flow ◽  
Sjögren‘S Syndrome

Patients with the salivary component of Sjögren's syndrome (SS) develop chronic xerostomia, which causes oral symptoms and functional impairment in approximate proportion to its severity. The purpose of this double-blind study was to determine whether an electrical stimulus applied to the tongue and hard palate by a battery-operated device (SAL II, Biosonics, Inc.) could stimulate salivary flow in subjects with generally severe SS. Twenty-nine patients with the salivary component of SS (diagnosed as the presence of focal chronic sialadenitis in a labial salivary gland biopsy specimen with a focus score of > 1 focus/4 mm2) were randomly assigned active or placebo devices, which they used for three minutes, three times a day for four weeks. Whole saliva flow rates were measured at weeks 0, 2, and 4 by collection of whole saliva both before and after stimulation with the device. Twenty-four subjects completed the study. The change in mean post-stimulation flow rate from week 0 to week 4 was greater for the 13 subjects using an active device (0.08 ± S.D. 0.08 gl2 min, to 0.24 ± 0.33 gl2 min) than for the 11 subjects using a placebo device (0.11 ± 0.15 gl2 min, to 0.08 ± 0.18 gl2 min) (p = 0.04). However, the magnitude of the mean difference was small, because three subjects using active devices responded and others did not. Only five subjects, all using active devices, reported a subjective increase in the amount of their saliva. The results of this study indicate that some SS patients with residual salivary flow show a significant response to electrical stimulation, but others with low or absent whole saliva flow rates do not respond.

Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults

1992 ◽  
Vol 71 (6) ◽  
pp. 1275-1278 ◽  
Author(s):  
M. Navazesh ◽  
R.A. Mulligan ◽  
V. Kipnis ◽  
P.A. Denny ◽  
P.C. Denny
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Young Group ◽  
Salivary Flow Rate ◽  
Flow Rates ◽  
Aged Group ◽  
Whole Saliva ◽  
Saliva Flow

Unstimulated and chewing-stimulated whole saliva samples were obtained from 42 healthy Caucasians; 21 were between 18 and 35 years of age, and 21 between 65 and 83 years of age. The unstimulated salivary flow rate was significantly lower in the aged group, but the stimulated flow rate was significantly higher in the aged than in the young group. Both groups showed significantly increased flow during salivary stimulation. MG1 and MG2 concentrations in unstimulated and stimulated saliva samples were significantly lower in the aged group. There were no significant correlations between salivary flow rates and MG1 and MG2 concentrations.

Specific Sialochemical and Sialometric Changes and Cariogenic Risk in Patients with Primary Sjogren`s Syndrome

2017 ◽  
Vol 68 (9) ◽  
pp. 2135-2138
Author(s):  
Codrina Ancuta ◽  
Cristina Angela Ghiorghe ◽  
Rodica Chirieac ◽  
Alice Arina Ciocan Pendefunda ◽  
Cristina Iordache
Keyword(s):  
Biochemical Analysis ◽  
Salivary Flow ◽  
Flow Rates ◽  
Increased Risk ◽  
Whole Saliva ◽  
Tooth Surfaces ◽  
Potential Impact ◽  
Bacterial Plaque ◽  
Saliva Flow ◽  
Saliva Composition

The main aim of our study was to perform a biochemical analysis of the saliva and to assess potential impact on oral health, particularly cariogenic issues, in patients with salivary secretory dysfunction such as primary Sjogren�s syndrome (pSSj). Consecutive pSSj and healthy age-matched controls were prospectively assessed for (i) whole saliva flow rates (unstimulated, RFR, and stimulated, RFS), pH and composition; (ii) cariogenic scores - decayed, missing and filled tooth surfaces (DMFS index), Silnes and Loe bacterial plaque index (PI). Salivary flow rates were significantly lower in pSSj for both unstimulated and stimulated tests (p[0.05), with a drop in pH as compared to healthy controls (p[005). Abnormal inorganic and organic saliva composition was reported in all cases comprising higher sodium, lower potassium and chloride concentrations, higher amylase activity and lower total protein (p[0.05). Statistically significant higher cariogenic scores particularly DMFS, were demonstrated in all pSSj (p[0.05). In conclusion, patients with pSSj are at increased risk to develop cariogenic issues due to both quantitative and qualitative salivary changes.

An Epidemiologic Perspective of Saliva Flow Rates as Indicators of Susceptibility to Oral Disease

1993 ◽  
Vol 4 (3) ◽  
pp. 351-356 ◽  
Author(s):  
Ronald J. Billings
Keyword(s):  
Salivary Flow ◽  
Root Surface ◽  
Oral Disease ◽  
Oral Diseases ◽  
Flow Rates ◽  
Relevant Effect ◽  
Whole Saliva ◽  
Pathologic Lesions ◽  
Saliva Flow ◽  
Study Participants

Catastrophic hyposalivation significantly increases susceptibility to dental caries in dentate individuals and may cause the expression or exacerbation of other oral diseases/disorders as well. The effect of subcatastrophic hyposalivation on susceptibility to caries or other diseases/disorders is less well understood. The aim of this study (part of a larger study on the prevalence of hyposalivation) was to determine the prevalence and to measure the association of oral pathologic conditions with unstimulated and stimulated whole saliva flow rates. Only 6.3% of all study participants had significantly diminished unstimulated (<0.05 ml/min) and stimulated (<0.50 ml/ min) saliva flow rates. A total of 15 individuals were encountered with oral pathologic lesions and none of these lesions were associated with hyposalivation. Although the prevalence of coronal caries, root surface caries, abrasion, and erosion tended to increase as salivary flow decreased, when the effect of age was considered no significant differences were present. These data suggest that low saliva flow rates alone, at least from an epidemiologic perspective, do not have a clinically relevant effect on susceptibility to oral diseases/disorders.

Stability of unstimulated and stimulated whole saliva flow rates in children

2015 ◽  
Vol 26 (5) ◽  
pp. 346-350 ◽  
Author(s):  
Leonor Sánchez-Pérez ◽  
Esther Irigoyen-Camacho ◽  
Laura Sáenz-Martínez ◽  
Marco Zepeda Zepeda ◽  
Enrique Acosta-Gío ◽  
...  
Keyword(s):  
Flow Rates ◽  
Whole Saliva ◽  
Saliva Flow

Preliminary Observations on the Effect of Mantle Field Radiotherapy on Salivary Flow Rates in Patients with Hodgkin's Disease

1988 ◽  
Vol 67 (2) ◽  
pp. 518-521 ◽  
Author(s):  
J.A. Bucher ◽  
T.J. Fleming ◽  
L.M. Fuller ◽  
H.J. Keene
Keyword(s):  
Flow Rate ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Salivary Flow ◽  
Mean Flow ◽  
Flow Rates ◽  
Whole Saliva ◽  
Preliminary Study ◽  
Saliva Flow ◽  
Therapeutic Doses

Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reductions of 54% for non-stimulated saliva and 55.7% for paraffin-stimulated saliva were observed post-radiotherapy. Flow rates had not returned to pre-irradiation levels in any of the patients who were observed for two to three months after completion of therapy. Results obtained from this preliminary study indicate that most patients who receive therapeutic doses of radiation to a mantle field experience a significant reduction in salivary output which is manifest during the period of treatment and persists for a period of at least two to three months post-radiotherapy.

scholarly journals Smoking Related Major- and Minor Salivary Gland Flow Rates, Xerostomia and Other Sicca Symptoms in Hungary

2020 ◽  
Vol 71 (4) ◽  
pp. 373-383
Author(s):  
Tamas Demeter ◽  
Melinda Penzes ◽  
Alexandra Kovacs ◽  
Katalin Karolyhazy ◽  
Csilla Erdei ◽  
...  
Keyword(s):  
Flow Rate ◽  
Smoking Status ◽  
Minor Salivary Gland ◽  
Age Groups ◽  
Heavy Smoker ◽  
Flow Rates ◽  
Saliva Flow Rate ◽  
Whole Saliva ◽  
Sicca Symptoms ◽  
Saliva Flow

Objectives of this study were to explore the prevalence of subjective and objective dryness symptoms by smoking status in different age groups, to measure whole and minor saliva flow rates, and to evaluate the possible associations between salivary parameters, oral symptoms and the intensity of smoking in a sample of Hungarian adults. Repeated cross-sectional studies were conducted in 2003 (n=600) and 2014�2018 (n=301) among Hungarian adults visiting regional outpatient dental clinics of their residence where dentist interviewed them about their subjective sicca symptoms and cigarette smoking habits (non-smoker � NS, light smoker � LIS, moderate or heavy smoker � MHS), and measured unstimulated whole saliva flow rate (UWS), palatal- and labial minor saliva flow rates to assess xerostomia objectively. The severity of xerostomia was significantly higher in among 30�39-year-old male smokers (44.8%; p=0.001), and among 18-29-year-old female smokers (52.9%; p=0.013), compared to their non-smoker counterparts (6.7% and 27.1%, respectively). UWS flow rate was significantly lower among 18-29-year-old MHS females compared to NS and LIS females in the same age group (p=0.019, p=0.015, respectively). Significantly increased palatal saliva flow rate was registered among 30�39-year-old MHS males compared to their NS counterparts (p=0.046). Our study highlighted that high intensity of smoking may cause xerostomia, a decrease in the UWS flow rate, and an increase in palatal saliva flow rate in some age groups, however, other sicca symptoms were mostly unrelated to the presence of dry mouth.

Flow Rates of Resting Whole and Stimulated Parotid Saliva in Relation to Age and Gender

1994 ◽  
Vol 73 (8) ◽  
pp. 1416-1420 ◽  
Author(s):  
R.S. Percival ◽  
SJ Challacombe ◽  
P.D. Marsh
Keyword(s):  
Age Groups ◽  
The Elderly ◽  
Elderly Subjects ◽  
Parotid Saliva ◽  
Age And Gender ◽  
Flow Rates ◽  
Whole Saliva ◽  
And Gender ◽  
Saliva Flow ◽  
Unstimulated Whole Saliva

Dry mouth is a common feature in the elderly, but it is not clear what proportion of incidences are related to functional disturbances and whether age per se and gender play a role. The aim of this study was to determine the effects of age and gender on salivary flow rates. The effect of age on unstimulated (resting) whole and stimulated parotid saliva flow rates was determined in 116 unmedicated, healthy individuals. The subjects were divided into four age groups: 20-39 years (group A), 40-59 years (group B), 60-79 years (group C), and 80 years and over (group D). A significant decrease in the secretion rates of unstimulated whole saliva in relation to age was observed in the study population (p < 0.001). However, the flow rates of stimulated parotid saliva were not significantly different in the four age groups. Females had significantly lower mean flow rates than males for both unstimulated (resting) whole saliva (p < 0.005) and stimulated parotid saliva (p < 0.05). In the study as a whole, significant negative correlations were found between either the DMF index (decayed, missing, and filled teeth) or the DMFS index (decayed, missing, and filled tooth surfaces) and the flow rates of unstimulated whole saliva (p < 0.02), but no relationship to stimulated parotid saliva flow rates was apparent. The results suggest that elderly subjects have no impairment in their ability to respond to sialogogues but that resting saliva rates are significantly lower than in younger individuals and may contribute to the increase in oral mucosal diseases seen in the elderly.

Salivary slgA concentrations and stimulated whole saliva flow rates among women undergoing chemotherapy for breast cancer: an exploratory study

1998 ◽  
Vol 18 (3) ◽  
pp. 109-112 ◽  
Author(s):  
Tonya Harrison ◽  
Lenora Bigler ◽  
Michelle Tucci ◽  
Lillian Pratt ◽  
Fernando Malamud ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Exploratory Study ◽  
Flow Rates ◽  
Whole Saliva ◽  
Saliva Flow

scholarly journals A műfogsorragasztó hatása a nyugalmi kevert és a kis nyálmirigyek szekréciójára, valamint a szájszárazság érzetére teljes lemezes fogpótlást viselőkben

2018 ◽  
Vol 159 (40) ◽  
pp. 1637-1644
Author(s):  
Tamás Demeter ◽  
Ahmad Behbahani Houman ◽  
Laura Gótai ◽  
Katalin Károlyházy ◽  
Alexandra Kovács ◽  
...  
Keyword(s):  
Minor Salivary Gland ◽  
The Other ◽  
Subjective Feeling ◽  
Flow Rates ◽  
Whole Saliva ◽  
Denture Adhesives ◽  
Sicca Symptoms ◽  
Student’S T ◽  
Saliva Flow ◽  
Unstimulated Whole Saliva

Abstract: Introduction and aim: To determine whether the continuous use of gel-type denture adhesives influence the unstimulated whole saliva, the palatal and labial saliva flow rates, and to assess the possible changes of subjective orofacial sicca symptoms. Method: 28 maxillary complete denture wearing patients (average age: 70 ± 10 years) were investigated. A gel-type denture adhesive was administered to the patients for regular use during the 3 weeks of examination. A questionnaire of 16 questions was used to evaluate subjective orofacial sicca symptoms. Unstimulated whole saliva was determined by the spitting method, palatal and labial saliva flow rates were measured by the Periotron® device with filter paper discs at the initial, first, second and third weeks. Statistical analysis: The following tests were used: subjective values – χ2-test; flow rates – ANOVA, paired Student’s t-test. Results: According to the questionnaire, the ratio or severity of xerostomia did not change. A significant increase in the subjective feeling of “saliva thickness” could be detected (p = 0.027), but the other subjective parameters remained unchanged. Palatal saliva flow rates decreased significantly by week 3 (week 0: 4.21 ± 3.96 µl/cm2/min; week 3: 2.21 ± 2.30 µl/cm2/min; p = 0.024). On the other hand, there was no significant change in the unstimulated whole saliva (week 0: 0.37 ± 0.36 ml/min; week 3: 0.39 ± 0.35 ml/min) and labial saliva (week 0: 3.99 ± 3.75 µl/cm2/min; week 3: 2.58 ± 3.39 µl/cm2/min) flow rates. Conclusions: The regular use of denture adhesives did not influence xerostomia and the majority of subjective orofacial sicca symptoms, but may cause a subjective feeling of “increased saliva thickness” and reduce palatal minor salivary gland flow rates among complete maxillary denture wearers. Orv Hetil. 2018; 159(40): 1637–1644.

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