An in vivo CT Study of Blood-Brain Barrier Permeability and Vascular Volume in a Brain Tumor Model: Potential Applications to Stereotactic Radiosurgery

1999 ◽  
pp. 135-152
Author(s):  
L.L. Stevens ◽  
T.Y. Lee ◽  
R.F. Maestro ◽  
J. Taylor ◽  
D. Ramsay ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Model ◽  
Model Potential ◽  
Barrier Permeability ◽  
Vascular Volume ◽  
Blood Brain Barrier Permeability ◽  
Brain Barrier Permeability ◽  
Potential Applications ◽  
Brain Tumor Model

scholarly journals Analysis of Fluorescence Decay Kinetics of Indocyanine Green Monomers and Aggregates in Brain Tumor Model In Vivo

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3185
Author(s):  
Dina Farrakhova ◽  
Igor Romanishkin ◽  
Yuliya Maklygina ◽  
Lina Bezdetnaya ◽  
Victor Loschenov
Keyword(s):  
Brain Tumor ◽  
Indocyanine Green ◽  
Fluorescence Lifetime ◽  
Tumor Model ◽  
Fluorescence Decay ◽  
Decay Kinetics ◽  
Lifetime Analysis ◽  
Fluorescence Decay Kinetics ◽  
Brain Tumor Model

Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye’s fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.

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