The Protective Effect of Melatonin in Viral and Bacterial Infections

1997 ◽  
pp. 72-80 ◽  
Author(s):  
D. Ben-Nathan ◽  
G.J.M. Maestroni ◽  
A. Conti
Keyword(s):  
Protective Effect ◽  
Bacterial Infections

The protective effect of fish-derived cathelicidins on bacterial infections in zebrafish, Danio rerio

2019 ◽  
Vol 92 ◽  
pp. 519-527 ◽  
Author(s):  
Chen Chen ◽  
Aili Wang ◽  
Fen Zhang ◽  
Minghui Zhang ◽  
Huaixin Yang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Danio Rerio ◽  
Bacterial Infections

Mannose-binding Lectin Expression Genotype in Pediatric-onset Systemic Lupus Erythematosus: Associations with Susceptibility to Renal Disease and Protection Against Infections

2011 ◽  
Vol 38 (7) ◽  
pp. 1429-1435 ◽  
Author(s):  
YI-CHAN TSAI ◽  
KOU-WEI YEH ◽  
TSUNG-CHIEH YAO ◽  
YU-LIN HUANG ◽  
MING-LING KUO ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Protective Effect ◽  
Lupus Erythematosus ◽  
Bacterial Infections ◽  
Systemic Lupus ◽  
Renal Disorders ◽  
Mannose Binding ◽  
Serious Bacterial Infections ◽  
Binding Lectin ◽  
Pediatric Onset

Objective.To study possible associations between extended mannose-binding lectin (MBL) expression genotypes and clinical manifestations and infections in children with systemic lupus erythematosus (SLE).Methods.Clinical and laboratory variables for a cohort of 125 patients with pediatric-onset SLE were obtained by clinical examinations and chart reviews. Controls were 137 age-matched and sex-matched healthy children and adolescents. MBL gene polymorphisms were genotyped by polymerase chain reaction. Serum MBL concentrations were measured by ELISA.Results.The frequencies of extended MBL expression genotypes did not differ between patients and controls. There were 82 patients with SLE who had high MBL expression genotypes and 43 who had medium and low MBL expression genotypes. Patients with the high MBL expression genotype had renal disorders more frequently than patients in the group with medium and low MBL expression genotypes [54/82 (65.9%) vs 18/43 (41.9%), respectively; p = 0.013] and fewer serious bacterial infections [22/82 (26.8%) vs 20/43 (46.5%); p = 0.030]. Using logistic regression for patients with SLE, a high MBL expression genotype was independently associated with renal disorders (OR 2.49, 95% CI 1.15–5.39, p = 0.021) and had a protective effect against serious bacterial infections (OR 0.29, 95% CI 0.12–0.71, p = 0.007). MBL levels decreased significantly when patients with active SLE reached an inactive stage (1.56 ± 0.55 μg/ml vs 1.08 ± 0.65 μg/ml; p = 0.001), but these levels were still higher than those in controls.Conclusion.Our findings suggest that a high MBL expression genotype is a risk factor for renal disorder, while it has a protective effect against infections. Serum MBL levels reflect SLE activity.

scholarly journals Protective Effect of Human Gamma Globulin Preparations on Experimental Bacterial Infections in Mice

1982 ◽  
Vol 56 (12) ◽  
pp. 1164-1172
Author(s):  
Toshikazu ARIOKA ◽  
Takeshi HONDA ◽  
Yoshifumi TAKEDA ◽  
Toshio MIWATANI
Keyword(s):  
Protective Effect ◽  
Bacterial Infections ◽  
Gamma Globulin ◽  
Human Gamma Globulin

scholarly journals Protective Effect of κ-Carrageenan against Bacterial Infections in Carp Cyprinus carpio

10.5109/24198 ◽  
1997 ◽  
Vol 42 (1/2) ◽  
pp. 113-119
Author(s):  
Kazuhiro Fujiki ◽  
Dong-Ho Shin ◽  
Miki Nakao ◽  
Tomoki Yano
Keyword(s):  
Protective Effect ◽  
Cyprinus Carpio ◽  
Bacterial Infections ◽  
Carp Cyprinus Carpio

Lycopene Ameliorate the Gentamicin Induced Nephrotoxicity in White Mice Model

2020 ◽  
Author(s):  
Abdalla Abdalla Abdalla Sayed
Keyword(s):  
Protective Effect ◽  
Inflammatory Cytokines ◽  
Bacterial Infections ◽  
Aminoglycoside Antibiotic ◽  
Treated Group ◽  
Protective Role ◽  
Serum Glucose ◽  
Mice Model ◽  
Oxidative Markers ◽  
The Face

Gentamicin is an aminoglycoside antibiotic used against gram-negative bacterial infections. In the face of antibiotics, gentamicin also has a toxic effect on kidney. This study investigated the protective role of lycopene against gentamicin induced nephrotoxicity. Results of this works found that lycopene has a great protective effect on the oxidative status of the kidney challenged with gentamicin and significantly ameliorated (P £ 0.05) the level of oxidative markers MDA, GPx and SOD in kidney cells. Kidney function markers (serum urea and creatinine) were ameliorated by using lycopene in comparison with mice challenged by gentamicin. Results of this work showed that lycopene decreased the pro-inflammatory cytokines (IL-6 and TNF-á) and anti-inflammatory cytokines (IL-4 and IL-10). mRNA expression rate of different investigated cytokine markers were modified significantly (P £ 0.05) in lycopene treated group. Serum glucose also adjusted significantly using lycopene. Oxidative stress results were confirmed by histopathological investigations those showed a protective effect of lycopene of kidney tubules.

Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death

Protective effect of Trypanosoma rangeli against infections with a highly virulent strain of Trypanosoma cruzi

1997 ◽  
Vol 2 (5) ◽  
pp. 482-487 ◽  
Author(s):  
Claudio Zuniga ◽  
Teresa Palau ◽  
Pilar Penin ◽  
Carlos Gamallo ◽  
Jose Antonio de Diego
Keyword(s):  
Trypanosoma Cruzi ◽  
Protective Effect ◽  
Virulent Strain ◽  
Trypanosoma Rangeli ◽  
Highly Virulent
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