Role of Angiogenesis and Angiogenic Growth Factors in Mucosal Repair and Ulcer Healing

2002 ◽  
pp. 101-116 ◽  
Author(s):  
A.S. Tarnawski ◽  
M.K. Jones ◽  
D. Baatar ◽  
R. Pai
Keyword(s):  
Growth Factors ◽  
Ulcer Healing ◽  
Angiogenic Growth Factors ◽  
Mucosal Repair

Role of angiogenic growth factors in transplant coronary artery disease

2004 ◽  
Vol 36 (3) ◽  
pp. 184-193 ◽  
Author(s):  
Karl Lemström ◽  
Antti Nykänen ◽  
Jussi Tikkanen ◽  
Rainer Krebs ◽  
Roope Sihvola ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Growth Factors ◽  
Coronary Artery ◽  
Angiogenic Growth Factors ◽  
Artery Disease

scholarly journals Vasculogenesis and Angiogenesis: Molecular and Cellular Controls

2003 ◽  
Vol 9 (3) ◽  
pp. 239-248 ◽  
Author(s):  
N. Kubis ◽  
B.I. Levy
Keyword(s):  
Endothelial Cells ◽  
Growth Factors ◽  
Endothelial Cell Migration ◽  
Angiogenic Growth Factors ◽  
Blood Vessel Formation ◽  
Vasculogenesis And Angiogenesis ◽  
Cell Migration And Proliferation ◽  
Extracellular Proteolysis ◽  
Coagulation And Fibrinolysis

Angiogenesis, defined as a new blood vessel formation from a pre-existing vessel, is initiated by angiogenic growth factors and their receptors that induce endothelial cell migration and proliferation. Extracellular proteolysis is essential for deassembly and reassembly of endothelial cells to their environmental matrix. The aim of this review is to update data on the role of the coagulation and fibrinolysis system, metalloproteinases and adhesion molecules during this step of angiogenesis.

scholarly journals Immunology and Genetic of Preeclampsia

2006 ◽  
Vol 13 (2-4) ◽  
pp. 197-201 ◽  
Author(s):  
Norma C. Serrano
Keyword(s):  
Developing Countries ◽  
Growth Factors ◽  
Fetal Death ◽  
Preventive Strategies ◽  
Angiogenic Growth Factors ◽  
Third Trimester ◽  
Maternal Circulation ◽  
Familial Predisposition ◽  
The Third

Preeclampsia is a disease characterized by hypertension and proteinuria in the third trimester of pregnancy. Preeclampsia is a major cause of maternal mortality, and fetal death, especially in developing countries, but its aetiology remains unclear. Key findings support a causal role of superficial placentation driven by immune mal maladaptation, which then lead to reduced concentrations of angiogenic growth factors and to an increase in placental debris in the maternal circulation resulting in a maternal inflammatory response. Epidemiological research has consistently demonstrated a substantial familial predisposition to preeclampsia. Unfortunately, the conquest of the genes explaining such a individual susceptibility has been proved to be a hard task. However, genetics will also inform us about causality of environmental factors, and then serve as a tool to prioritize therapeutic targets for preventive strategies.

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing

2018 ◽  
Vol 24 (18) ◽  
pp. 1972-1989 ◽  
Author(s):  
Sven Seiwerth ◽  
Rudolf Rucman ◽  
Branko Turkovic ◽  
Marko Sever ◽  
Robert Klicek ◽  
...  
Keyword(s):  
Growth Factors ◽  
Gastrointestinal Tract ◽  
Bone Healing ◽  
Angiogenic Growth Factors ◽  
Chronic Injury ◽  
Bpc 157 ◽  
Beneficial Effects ◽  
Pathophysiological Role

Commonly, the angiogenic growth factors signify healing. However, gastrointestinal ulceration is still poorly understood particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemented in growth factors wound healing concept. Thereby, we focused on the stable gastric pentadecapeptide BPC 157, a peptide given always alone vs. standard peptidergic angiogenic growth factors (EGF, FGF, VEGF), and numerous carriers. Further, we reviewed how the gastrointestinal tract healing could be generally perceived (i) in terms of angiogenic growth factors, and/or (ii) through the healing of extragastrointestinal tissues healing, such as tendon, ligament, muscle and bone, and vice versa. Respected were the beneficial effects obtained with free peptides or peptides with different carriers; EGF, FGF, VEGF, and BPC 157, their presentation along with injuries, and a healing commonality, providing their implementation in both gastrointestinal ulcer healing and tendon, ligament, muscle and bone healing. Only BPC 157 was consistently effective in all of the models of acute/chronic injury of esophagus, stomach, duodenum and lower gastrointestinal tract, intraperitoneally, per-orally or locally. Unlike bFGF-, EGF-, VEGF-gastrointestinal tract studies demonstrating improved healing, most of the studies on tendon, muscle and bone injuries provide evidence of their (increased) presentation along with the various procedures used to produce beneficial effects, compared to fewer studies in vitro, while in vivo healing has a limited number of studies, commonly limited to local application, diverse healing evidence with diverse carriers and delivery systems. Contrary to this, BPC 157 - using same regimens like in gastrointestinal healing studies - improves tendon, ligament and bone healing, accurately implementing its own angiogenic effect in the healing. Thus, we claim that just BPC 157 represents in practice a pharmacological and pathophysiological role of various peptidergic growth factors.

Tissue Engineered Tumor Microvessels to Study the Role of Flow Shear Stress on Endothelial Barrier Function

2013 ◽  
Author(s):  
Cara F. Buchanan ◽  
Elizabeth Voigt ◽  
Pavlos P. Vlachos ◽  
Marissa Nichole Rylander
Keyword(s):  
Shear Stress ◽  
Growth Factors ◽  
Vascular Function ◽  
Fluid Pressure ◽  
Compressive Force ◽  
Lymphatic Drainage ◽  
Angiogenic Growth Factors ◽  
Flow Shear ◽  
Flow Shear Stress

As solid tumors develop, a variety of physical stresses arise including growth induced compressive force, matrix stiffening due to desmoplasia, and increased interstitial fluid pressure and altered flow patterns due to leaky vasculature and poor lymphatic drainage [1]. These microenvironmental stresses likely contribute to the abnormal cell behavior that drives tumor progression, and have become an increasingly significant area of cancer research. Of particular importance, is the role of flow shear stress on tumor-endothelial signaling, vascular function, and angiogenesis. Compared to normal vasculature, blood vessels in tumors are poorly functional due to dysregulated expression of angiogenic growth factors, such as vascular endothelial growth factor (VEGF) or the angiopoietins. Also, because of the abnormal vessel structure, blood velocities can be an order of magnitude lower than that of normal microvessels. Recently published work utilizing intravital microscopy to measure blood velocities in mouse mammary fat pad tumors, demonstrated for the first time that shear rate gradients in tumors may help guide branching and growth of new vessels [2]. However, much still remains unknown about how shear stress regulates endothelial organization, permeability, or expression of growth factors within the context of the tumor microenvironment.

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