Coupled Plasma Filtration Adsorption in the Treatment of Septic Shock

2001 ◽  
pp. 383-390 ◽  
Author(s):  
A. Brendolan ◽  
R. Bellomo ◽  
C. Tetta ◽  
P. Piccinni ◽  
A. Digito ◽  
...  
Keyword(s):  
Septic Shock ◽  
Plasma Filtration

A pilot study of coupled plasma filtration with adsorption in septic shock*

2002 ◽  
Vol 30 (6) ◽  
pp. 1250-1255 ◽  
Author(s):  
Claudio Ronco ◽  
Alessandra Brendolan ◽  
Gerhard Lonnemann ◽  
Rinaldo Bellomo ◽  
Pasquale Piccinni ◽  
...  
Keyword(s):  
Septic Shock ◽  
Pilot Study ◽  
Plasma Filtration

scholarly journals Regional Citrate Anticoagulation During Coupled Plasma Filtration and Adsorption May Increase Survival in Septic Shock

2018 ◽  
Vol 47 (1-3) ◽  
pp. 111-112
Author(s):  
Giorgio Berlot ◽  
Stefano Falini ◽  
Virginia Negro ◽  
Antoinette Agbedjro ◽  
Ariella Tomasini ◽  
...  
Keyword(s):  
Septic Shock ◽  
Regional Citrate Anticoagulation ◽  
Citrate Anticoagulation ◽  
Plasma Filtration

scholarly journals Coupled-plasma filtration and adsorption for severe burn patients with septic shock and acute kidney injury treated with renal replacement therapy

Burns ◽  
2020 ◽  
Vol 46 (1) ◽  
pp. 190-198 ◽  
Author(s):  
Filippo Mariano ◽  
Zsuzsanna Hollo’ ◽  
Nadia Depetris ◽  
Valeria Malvasio ◽  
Alberto Mella ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Kidney Injury ◽  
Burn Patients ◽  
Severe Burn ◽  
Plasma Filtration

Influence of Timing of Initiation and Volume of Processed Plasma on the Outcome of Septic Shock Patients Treated with Coupled Plasma Filtration and Adsorption

2018 ◽  
Vol 46 (4) ◽  
pp. 274-278
Author(s):  
Giorgio Berlot ◽  
Stefano Falini ◽  
Virginia Negro ◽  
Antoinette Agbedjro ◽  
Ariella Tomasini ◽  
...  
Keyword(s):  
Septic Shock ◽  
First Episode ◽  
Time Interval ◽  
Multiple Logistic Regression ◽  
Treatment Results ◽  
Plasma Filtration ◽  
Timing Of Initiation ◽  
Extracorporeal Removal ◽  
Intensity Of Treatment

Background: The extracorporeal removal of mediators is a rescue strategy for septic shock patients, which is still under investigation. Several techniques are available: coupled plasma filtration and adsorption (CPFA) combines plasma processing with renal replacement therapy. Methods: The study aimed to elucidate the role of both timing of initiation and intensity of treatment on the outcome, for which we retrospectively studied 52 patients. We collected the overall pre-CPFA time interval, starting from the first episode of hypotension in the wards and the volume of processed plasma (Vp), which we used as a proxy for intensity of treatment. Results: Timing of initiation did not significantly differ between survivors and non-survivors (25 vs. 27 h), while the Vp did (0.25 vs. 0.17 L/kg/session, p < 0.05). The significance of Vp was confirmed by a multiple logistic regression model. Conclusion: Our study confirms that intensity of CPFA, but not its timing of initiation, correlates with survival of septic shock patients.

scholarly journals TO013ADSORPTION THERAPY AND SEPTIC SHOCK: A RETROSPECTIVE STUDY COMPARING COUPLED PLASMA FILTRATION-ADSORPTION AND CYTOSORB

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Vittorio Di Maso ◽  
Domenico Grecò ◽  
Martina Cozzi ◽  
Elisa Bedina ◽  
Ugo Gerini ◽  
...  
Keyword(s):  
Septic Shock ◽  
Observational Study ◽  
Kidney Function ◽  
Sofa Score ◽  
Pressure Ratio ◽  
Complete Recovery ◽  
Post Treatment ◽  
Retrospective Observational Study ◽  
Renal Outcome ◽  
Plasma Filtration

Abstract Background and Aims Septic shock is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Excessive release of cytokines and other inflammatory mediators is a key mechanism and cytokines adsorption therapies are applied in this context to restore a balanced immune homeostasis. Different adsorption techniques are available but there are no studies comparing these different adsorption approaches. The aim of this retrospective observational study was to compare Coupled Plasma Filtration Adsorption (CPFA) and CytoSorbTM in terms of hemodynamic and clinical response, mortality and renal function recovery. Method A retrospective observational study was designed enrolling all patients admitted to ICU with a diagnosis of septic shock treated with blood adsorption, either CPFA or CytoSorbTM, from January 2015 to December 2017. Primary endpoints of the study were the assessment of changes in NE dosage, MAP values, SOFA score and PCT levels before and after blood adsorption. Secondary endpoints ICU length of stay (LOS), mortality at 30, 60 and 90 days from adsorption initiation; renal outcome at 30 and 90 days from adsorption initiation. Results The study included 28 patients (14 CPFA, 14 CytosorbTM). Adsorption treatment was associated with a significant (p=0.03) improvement in hemodynamics with a Norepinephrine/Mean Arterial Pressure ratio (NE/MAP) of 0.64 (0.14-2.6) pre-treatment vs 0.11 (0.0-0.32) post-treatment regardless of the applied technique. Furthermore, a significant (p&lt;0.001) procalcitonin (PCT) post treatment reduction was demonstrated with a comparable effect in the two groups (p=0.32) (Fig.1). No difference has been found in SOFA score changes (p=0.06) and again without any difference between groups (p=0.17). Overall Survival (OS) rate at 30 days was comparable between groups being 64.3% in CPFA and 78.6% in CytoSorbTM group (p=0.34). Finally, a complete recovery of kidney function at 30 and 90 days has been obtained in respectively 90% and 100% of survived patients without any difference between groups (p=1.00) (Fig.2). Conclusion These data confirmed the effectiveness of adsorption in terms of short-term clinical improvement independently from the applied technique, supporting the role of both these adjunctive therapies in septic shock treatment. CPFA and CytosorbTM have comparable effects in terms of hemodynamic improvement, clinical outcome, mortality and recovery of kidney function from septic shock AKI.

scholarly journals Coupled plasma filtration adsorption in peritonitis-induced porcine hyperdynamic septic shock

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P460
Author(s):  
R Sykora ◽  
J Chvojka ◽  
A Krouzecky ◽  
J Radej ◽  
V Varnerova ◽  
...  
Keyword(s):  
Septic Shock ◽  
Plasma Filtration ◽  
Hyperdynamic Septic Shock
Sign in / Sign up

Export Citation Format

Share Document