The Impact of Residual Renal Function on the Adequacy of Peritoneal Dialysis

1998 ◽  
pp. 76-102 ◽  
Author(s):  
N.H. Lameire
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Residual Renal Function ◽  
The Impact

scholarly journals The Impact of Fluid Overload and Variation on Residual Renal Function in Peritoneal Dialysis Patient

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153115 ◽  
Author(s):  
Na Tian ◽  
Qunying Guo ◽  
Qian Zhou ◽  
Peiyi Cao ◽  
Lingyao Hong ◽  
...  
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Dialysis Patient ◽  
Fluid Overload ◽  
Peritoneal Dialysis Patient ◽  
Residual Renal Function ◽  
The Impact

The Impact of Peritoneal Permeability and Residual Renal Function on Pd Prescription

1996 ◽  
Vol 16 (1_suppl) ◽  
pp. 147-152 ◽  
Author(s):  
John Harty ◽  
Ram Gokal
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Creatinine Clearance ◽  
Model Simulation ◽  
High Volume ◽  
Residual Renal Function ◽  
Peritoneal Transport ◽  
Target Values ◽  
Peritoneal Permeability ◽  
The Impact

Our objective was to evaluate the impact of peritoneal transport characteristics and residual renal function on peritoneal clearance and to determine the dialysis volume required to achieve targets for KT/V and weekly creatinine clearance (WCC) in patients with differing weights, renal function, and transport status. Retrospective analysis and mathematical model simulation of urea and creatinine clearance were used. This review demonstrates the important contribution of both residual renal function and peritoneal transport in attaining target values for KT/V and WCC. The limitations of a standard 4 x 2 L dialysis prescription are highlighted in anuric patients and those with low peritoneal transport. In addition, the limitations of short dwell, rapid exchange dialysis modalities are emphasized, especially in patients with low and low average peritoneal transport where daily clearance is demonstrated to be considerably less than conventional continuous ambulatory peritoneal dialysis (CAPD). Attainment of proposed targets for KT/V (1.7) and WCC (50 L) is greatly dependent on residual renal function. In CAPD, peritoneal transport characteristics determine urea clearance through an effect on ultrafiltrate. Thus low transporters of identical weight will have greater values for peritoneal dialysis KT/V. Creatinine clearance is considerably influenced by transport status. The majority of low and low average groups will need some degree of renal function to achieve currently proposed targets. In these patients, conversion to high volume, short dwell modalities will further compromise small solute clearance unless daytime long dwells or tidal dialysis is instigated.

Therapeutic Options for Preservation of Residual Renal Function in Patients on Peritoneal Dialysis

2007 ◽  
Vol 27 (2_suppl) ◽  
pp. 158-163
Author(s):  
Philip KamTao Li ◽  
Yuk Lun Cheng
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Antihypertensive Agents ◽  
Cost Savings ◽  
Residual Renal Function ◽  
Phosphate Binders ◽  
Kidney Functions ◽  
The Impact ◽  
The Ideal

Dialysis is not the ideal renal replacement therapy because it does not fully restore all kidney functions. Increasing evidence suggests that preservation of residual renal function is associated with a survival benefit, a decrease in morbidity, better nutrition, a lower level of inflammatory markers, an improved quality of life, and cost savings by obviating the need for more peritoneal dialysis exchanges and possibly by reducing the requirement for antihypertensive agents, phosphate binders, and erythropoietin. In the present article, we review the impact of residual renal function on patient outcomes and the renoprotective strategies available in patients on peritoneal dialysis.

scholarly journals Residual Renal Function and Effect of Low-Sodium Solution on Blood Pressure in Peritoneal Dialysis Patients

2019 ◽  
Vol 39 (4) ◽  
pp. 335-343 ◽  
Author(s):  
Bolesław Rutkowski ◽  
Paul Tam ◽  
Frank M. van der Sande ◽  
Andreas Vychytil ◽  
Vedat Schwenger ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Peritoneal Dialysis ◽  
Antihypertensive Medication ◽  
Residual Renal Function ◽  
Double Blind ◽  
Low Sodium ◽  
Peritoneal Dialysis Fluid ◽  
Daily Dose ◽  
The Impact

BackgroundResidual renal function (RRF) affects sodium and fluid balance. The aim of this analysis was to examine the impact of RRF on the effect of a sodium-reduced peritoneal dialysis fluid (PDF) on blood pressure (BP).MethodsThis is a post-hoc analysis of a prospective, randomized, controlled double-blind clinical trial with 82 patients on continuous ambulatory PD (CAPD) treated with a low-sodium (125 mmol/L Na) or a standard-sodium (134 mmol/L Na) PDF. Subgroups according to glomerular filtration rate (GFR) at baseline (≤ / > 6 mL/min/1.73 m2) were analyzed for BP and antihypertensive medication.ResultsIn the low-GFR group on low-sodium PDF ( N = 26), systolic BP was reduced from 152 ± 24 mmHg at baseline to 137 ± 21 mmHg at week 12, diastolic BP from 90 ± 16 mmHg to 83 ± 11 mmHg. In the low-GFR group on standard-sodium PDF and in the high-GFR group on both PDF types, only minor changes were observed. For the low-GFR subgroup, the confounder-adjusted mean study group difference in systolic BP at week 12 between low-sodium and standard-sodium PDF was -16.9 (95% confidence interval [CI] -27.2 to -6.6) mmHg, for diastolic BP, it was -7.0 (95% CI -12.6 to -1.4) mmHg. In both GFR subgroups, more patients had a reduced daily dose of antihypertensive medication and fewer patients an increased daily dose in the low-sodium compared with the standard-sodium group at week 12.ConclusionsThe reduction of BP with a sodium-reduced PDF seems to be more effective in patients with no or low RRF than in patients with residual capacity of renal sodium and fluid control.

scholarly journals Effluent Free Radicals Are Associated with Residual Renal Function and Predict Technique Failure in Peritoneal Dialysis Patients

2012 ◽  
Vol 32 (4) ◽  
pp. 453-461 ◽  
Author(s):  
Hiroshi Morinaga ◽  
Hitoshi Sugiyama ◽  
Tatsuyuki Inoue ◽  
Keiichi Takiue ◽  
Yoko Kikumoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Peritoneal Dialysis ◽  
Free Radicals ◽  
Patient Survival ◽  
Urine Volume ◽  
Residual Renal Function ◽  
Significant Difference ◽  
The Impact ◽  
Technique Failure

ObjectiveResidual renal function (RRF) is associated with low oxidative stress in peritoneal dialysis (PD). In the present study, we investigated the relationship between the impact of oxidative stress on RRF and patient outcomes during PD.MethodsLevels of free radicals (FRs) in effluent from the overnight dwell in 45 outpatients were determined by electron spin resonance spectrometry. The FR levels, clinical parameters, and the level of 8-hydroxy-2′-deoxyguanosine were evaluated at study start. The effects of effluent FR level on technique and patient survival were analyzed in a prospective cohort followed for 24 months.ResultsLevels of effluent FRs showed significant negative correlations with daily urine volume and residual renal Kt/V, and positive correlations with plasma β2-microglobulin and effluent 8-hydroxy-2′-deoxyguanosine. A highly significant difference in technique survival ( p < 0.05), but not patient survival, was observed for patients grouped by effluent FR quartile. The effluent FR level was independently associated with technique failure after adjusting for patient age, history of cardiovascular disease, and presence of diabetes mellitus ( p < 0.001). The level of effluent FRs was associated with death-censored technique failure in both univariate ( p < 0.001) and multivariate ( p < 0.01) hazard models. Compared with patients remaining on PD, those withdrawn from the modality had significantly higher levels of effluent FRs ( p < 0.005).ConclusionsElevated effluent FRs are associated with RRF and technique failure in stable PD patients. These findings highlight the importance of oxidative stress as an unfavorable prognostic factor in PD and emphasize that steps should be taken to minimize oxidative stress in these patients.

The impact of residual renal function on quality of life in patients with peritoneal dialysis

2018 ◽  
Vol 90 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Wei Zhou ◽  
Weifeng Hu ◽  
Guofeng Han ◽  
Huiling Wang ◽  
Jinyuan Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Renal Function ◽  
Peritoneal Dialysis ◽  
Residual Renal Function ◽  
The Impact

RESIDUAL RENAL FUNCTION IN PERITONEAL DIALYSIS PATIENTS

2011 ◽  
pp. 30-34
Author(s):  
Hoang Bui Bao Hoang ◽  
Huu Loi Le ◽  
Tam Vo ◽  
Thi Anh Thu Tran
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Close Correlation ◽  
Residual Renal Function ◽  
Central Hospital ◽  
Dialysis Patients

Background: Peritoneal dialysis is used regularlly in treatment of ESRDs. Residual renal function (RRF) in these patients helps the adequacy of PD therapy very much. Objectives: 1. Study RRF of PD patients at Department of Nephro – Rheumatology, Hue Central Hospital. 2. Search the correlation between RRF and Kt/V. Patients and methods: 35 PD patients at Department of Nephro – Rheumatology, Hue Central Hospital. Measure RRF and Kt/V by formulars that depend on blood, urine and PD fluid samples. Results: Mean RRF of PD patients is 4.36 ± 13.8 ml/minute. There is a close correlation between RRF and Kt/V (r=0.79, p<0.01). Conclusion: RRF in PD patients correlates with Kt/V.

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