Elevated Nasal Mucosal G Protein Levels and Histamine Receptor Affinity in a Guinea Pig Model of Nasal Hyperresponsiveness

2002 ◽  
Vol 127 (4) ◽  
pp. 285-293 ◽  
Author(s):  
Yoshihiko Chiba ◽  
Nobuyuki Saitoh ◽  
Kensuke Matsuo ◽  
Miwa Misawa
Keyword(s):  
Guinea Pig ◽  
G Protein ◽  
Histamine Receptor ◽  
Pig Model ◽  
Receptor Affinity ◽  
Protein Levels ◽  
Guinea Pig Model

scholarly journals Endoplasmic Reticulum Stress Regulates Scleral Remodeling in a Guinea Pig Model of Form-Deprivation Myopia

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Chengcheng Zhu ◽  
Qingzhong Chen ◽  
Ying Yuan ◽  
Min Li ◽  
Bilian Ke
Keyword(s):  
Endoplasmic Reticulum ◽  
Guinea Pig ◽  
Er Stress ◽  
Western Blotting ◽  
Guinea Pigs ◽  
Pig Model ◽  
Ultrastructural Changes ◽  
Protein Levels ◽  
Guinea Pig Model

Purpose. This study aimed to investigate the role of endoplasmic reticulum (ER) stress in scleral remodeling in a guinea pig model of form-deprivation myopia (FDM). Methods. Guinea pigs were form deprived to induce myopia. ER ultrastructural changes in the sclera were examined by transmission electron microscopy (TEM). The protein levels of ER stress chaperones, including GRP78, CHOP, and calreticulin (CRT), were analyzed by western blotting at 24 hours, 1 week, and 4 weeks of FD. Scleral fibroblasts from guinea pigs were cultured and exposed to the ER stress inducer tunicamycin (TM) or the ER stress inhibitor 4-phenylbutyric acid (4-PBA). CRT was knocked down by lentivirus-mediated CRT shRNA transfection. The expression levels of GRP78, CHOP, TGF-β1, and COL1A1 were analyzed by qRT-PCR or western blotting. Results. The sclera of FDM eyes exhibited swollen and distended ER at 4 weeks, as well as significantly increased protein expression of GRP78 and CRT at 1 week and 4 weeks, compared to the sclera of the control eyes. In vitro, TM induced ER stress in scleral fibroblasts, which was suppressed by 4-PBA. The mRNA expression of TGF-β1 and COL1A1 was upregulated after TM stimulation for 24 hours, but downregulated for 48 hours. Additionally, change of TGF-β1 and COL1A1 transcription induced by TM was suppressed by CRT knockdown. Conclusions. ER stress was an important modulator which could influence the expression of the scleral collagen. CRT might be a new target for the intervention of the FDM scleral remodeling process.

In vivo activity of pyrimidine-dispirotripiperaziniumin in the male guinea pig model of genital herpes

2020 ◽  
Vol 09 (01) ◽  
Author(s):  
Novoselova EA ◽  
Alimbarova LM ◽  
Monakhova NS ◽  
Lepioshkin AY ◽  
Ekins S ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Genital Herpes ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Listeria adhesion protein-expressing bioengineered probiotics prevent fetoplacental transmission of Listeria monocytogenes in a pregnant Guinea pig model

2021 ◽  
Vol 151 ◽  
pp. 104752
Author(s):  
Valerie E. Ryan ◽  
Taylor W. Bailey ◽  
Dongqi Liu ◽  
Tracy Vemulapalli ◽  
Bruce Cooper ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Guinea Pig ◽  
Pig Model ◽  
Adhesion Protein ◽  
Listeria Adhesion Protein ◽  
Guinea Pig Model

scholarly journals Quantitative cartilage degeneration associated with spontaneous osteoarthritis in a guinea pig model

2011 ◽  
Vol 35 (4) ◽  
pp. 891-898 ◽  
Author(s):  
Matthew C. Fenty ◽  
George R. Dodge ◽  
Victor Babu Kassey ◽  
Walter R.T. Witschey ◽  
Arijitt Borthakur ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cartilage Degeneration ◽  
Pig Model ◽  
Guinea Pig Model

Suppression of Late Asthmatic Response by Low-Dose Oral Administration of Interferon-beta in the Guinea Pig Model of Asthma

1999 ◽  
Vol 19 (8) ◽  
pp. 887-894 ◽  
Author(s):  
Yu-Ichiro Satoh ◽  
Kyoko Kasama ◽  
Mikiko Kuwabara ◽  
Hong-Yan Diao ◽  
Hirofumi Nakajima ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Oral Administration ◽  
Low Dose ◽  
Interferon Beta ◽  
Pig Model ◽  
Asthmatic Response ◽  
Late Asthmatic Response ◽  
Dose Oral ◽  
Guinea Pig Model

scholarly journals Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 749 ◽  
Author(s):  
Stine Hansen ◽  
Jane Jørgensen ◽  
Jens Nyengaard ◽  
Jens Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Synaptic Plasticity ◽  
Vitamin C ◽  
Guinea Pig ◽  
Early Life ◽  
Pyramidal Neurons ◽  
Pig Model ◽  
Vitamin C Deficiency ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Guinea Pig Model
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