scholarly journals Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 749 ◽  
Author(s):  
Stine Hansen ◽  
Jane Jørgensen ◽  
Jens Nyengaard ◽  
Jens Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Synaptic Plasticity ◽  
Vitamin C ◽  
Guinea Pig ◽  
Early Life ◽  
Pyramidal Neurons ◽  
Pig Model ◽  
Vitamin C Deficiency ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Guinea Pig Model

scholarly journals Vitamin C Prevents Cigarette Smoke Induced Atherosclerosis in Guinea Pig Model

2010 ◽  
Vol 17 (8) ◽  
pp. 817-827 ◽  
Author(s):  
Tanusree Ray ◽  
Palash Chandra Maity ◽  
Sumana Banerjee ◽  
Suryyani Deb ◽  
Anjan Kumar Dasgupta ◽  
...  
Keyword(s):  
Vitamin C ◽  
Guinea Pig ◽  
Cigarette Smoke ◽  
Pig Model ◽  
Guinea Pig Model

Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model

2017 ◽  
Vol 8 (5) ◽  
pp. 584-596 ◽  
Author(s):  
A. L. Cumberland ◽  
H. K. Palliser ◽  
P. Rani ◽  
D. W. Walker ◽  
J. J. Hirst
Keyword(s):  
Guinea Pig ◽  
Prenatal Stress ◽  
Intrauterine Growth Restriction ◽  
Fetal Brain ◽  
Later Life ◽  
Growth Restriction ◽  
Pig Model ◽  
Flow Restriction ◽  
Hippocampal Ca1 ◽  
Guinea Pig Model

Intrauterine growth restriction (IUGR) and maternal stress during pregnancy are two compromises that negatively impact neurodevelopment and increase the risk of developing later life neuropsychiatric disorders such as schizophrenia, depression and behavioural disorders. Neurosteroids, particularly allopregnanolone, are important in protecting the developing brain and promoting many essential neurodevelopmental processes. Individually, IUGR and prenatal stress (PS) reduce myelination and neurogenesis within affected fetal brains, however less information is available on the combined effects of these two disorders on the term fetal brain. This study aimed to investigate how IUGR and PS impairs the neurosteroid pathway when combined using a guinea pig model, and how these then disrupt the neurodevelopment of the fetus. Uterine artery blood flow restriction was performed at GA30-35 to induce growth restriction, whilst PS was induced by exposure of the dam to a strobe light during gestation commencing GA40 and repeated every 5 days. Exposure in this model caused reductions in hippocampal CA1 MBP immunostaining of male fetuses in both IUGR alone and IUGR+PS paradigms but only by IUGR in the subcortical white mater, compared with control males. Plasma allopregnanolone was reduced by both stressors irrespective of sex, whereas GFAP or MAP2 expression were not affected by either stressor. Female neurodevelopment, as assessed by these markers, was unimpeded by these compromises. The addition of prenatal stress did not further compound these deficits.

scholarly journals Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10306 ◽  
Author(s):  
Jian-Yi Xu ◽  
Rongqing Chen ◽  
Jian Zhang ◽  
Chu Chen
Keyword(s):  
Synaptic Plasticity ◽  
Pyramidal Neurons ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1
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