Concentrations of Serum Albumin and Nonesterified Fatty Acids in Bovine Aqueous Humor with Regard to the Fatty Acid Sensitivity of Bovine Lens Epithelial Cells

2000 ◽  
Vol 32 (4) ◽  
pp. 151-156 ◽  
Author(s):  
Mike John ◽  
Dietmar Glaesser
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Epithelial Cells ◽  
Serum Albumin ◽  
Aqueous Humor ◽  
Lens Epithelial Cells ◽  
Nonesterified Fatty Acids ◽  
Acid Sensitivity ◽  
Bovine Lens

Effect of Rabbit Aqueous Humor Obtained after Cataract Surgery on Collagen Gel Contraction Induced by Bovine Lens Epithelial Cells

2000 ◽  
Vol 32 (2-3) ◽  
pp. 94-99 ◽  
Author(s):  
Daijiro Kurosaka ◽  
Katsuhiko Kato ◽  
Takeshi Oshima ◽  
Hiroyo Kurosaka ◽  
Mami Yoshino ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cataract Surgery ◽  
Aqueous Humor ◽  
Collagen Gel ◽  
Lens Epithelial Cells ◽  
Bovine Lens ◽  
Collagen Gel Contraction

scholarly journals Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ban-Hock Khor ◽  
◽  
Sharmela Sahathevan ◽  
Ayesha Sualeheen ◽  
Mohammad Syafiq Md Ali ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Nutritional Status ◽  
Serum Albumin ◽  
Saturated Fatty Acids ◽  
Maintenance Hemodialysis ◽  
Model Assessment ◽  
Cross Sectional ◽  
Markers Of Inflammation

AbstractThe metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r =  − 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r =  − 0.197) and serum albumin (r =  − 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r =  − 0.168) and interleukin-6 concentrations (r =  − 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r =  − 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters.

Seasonal Variation in Plasma Nonesterified Fatty Acids of Lake Sturgeon (Acipenser fulvescens) in the Vicinity of Hydroelectric Facilities

1993 ◽  
Vol 50 (11) ◽  
pp. 2440-2447 ◽  
Author(s):  
R. S. McKinley ◽  
T. D. Singer ◽  
J. S. Ballantyne ◽  
G. Power
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Lake Sturgeon ◽  
Acipenser Fulvescens ◽  
Total Plasma ◽  
Nefa Concentration ◽  
Plasma Nefa ◽  
Nonesterified Fatty Acids ◽  
Plasma Nefa Concentration ◽  
Fatty Acid Species

To establish the effects of hydroelectric generation on the health of lake sturgeon (Acipenser fulvescens), seasonal variations in plasma nonesterified fatty acids (NEFAs) upstream and downstream from hydroelectric stations were measured over a 2-yr period. Plasma NEFA profiles were also compared up- and downstream of the stations for differences in utilization of individual NEFA species as substrates for lipid oxidation. Significantly higher levels of total plasma NEFA were found in lake sturgeon upstream (2355 ± 395.9 nmol/mL) compared with those downstream (798 ± 133.5 nmol/mL) of the generating stations during the spring. The NEFA profiles for several key fatty acid species differed significantly among seasons up- and downstream of the facilities. In particular, during spring and summer, the levels of oleic acid (18:1n9) were highest upstream of the stations and levels of a polyunsaturated fatty acid, docosahexaenoic acid (22:6n3), were higher below rather than above the stations. The differences in plasma NEFA concentration may be attributed to altered nutritional status due to the varying flow regime located downstream of the hydroelectric stations.

Intramuscular fatty acid metabolism evaluated with stable isotopic tracers

1998 ◽  
Vol 84 (5) ◽  
pp. 1674-1679 ◽  
Author(s):  
Zengkui Guo ◽  
Michael D. Jensen
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Isotope Ratio Mass Spectrometry ◽  
Isotopic Tracers ◽  
Nonesterified Fatty Acids ◽  
Stable Isotopic ◽  
Fractional Synthesis ◽  
Intramuscular Triglyceride

We evaluated the applicability of stable isotopic tracers to the study of intramuscular fatty acid metabolism by infusing both [U-13C]palmitate and [1-13C]oleate intravenously for 4 h into fasted conscious rats. Skeletal muscles were sequentially biopsied, and the concentration and13C enrichment of fatty acids were measured by gas chromatography/combustion/isotope ratio mass spectrometry. Throughout the study, the13C enrichment of plasma palmitate and oleate remained substantially greater than intramuscular nonesterified palmitate and oleate enrichment, which in turn was greater than intramuscular triglyceride palmitate and oleate enrichment. Fractional synthesis rates of intramuscular triglycerides in gastrocnemius and soleus were 0.267 ± 0.075 and 0.100 ± 0.030/h ( P = 0.04), respectively, as determined by using [U-13C]palmitate, and were 0.278 ± 0.049 and 0.075 ± 0.013/h ( P = 0.02), respectively, by using [1-13C]oleate. We conclude that plasma free fatty acids are a source for intramuscular triglycerides and nonesterified fatty acids; the latter are likely the synthetic precursors of the former. Uniformly and singly labeled [13C]fatty acid tracers will provide an important tool to study intramuscular fatty acid and triglyceride metabolism.

Improved energy homeostasis of the heart in the metabolic state of exercise

2000 ◽  
Vol 279 (4) ◽  
pp. H1490-H1501 ◽  
Author(s):  
Gary W. Goodwin ◽  
Heinrich Taegtmeyer ◽  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Energy Homeostasis ◽  
Acid Oxidation ◽  
High Fat ◽  
Nonesterified Fatty Acids ◽  
Malonyl Coa ◽  
Metabolic Conditions ◽  
High Lactate

We postulate that metabolic conditions that develop systemically during exercise (high blood lactate and high nonesterified fatty acids) are favorable for energy homeostasis of the heart during contractile stimulation. We used working rat hearts perfused at physiological workload and levels of the major energy substrates and compared the metabolic and contractile responses to an acute low-to-high work transition under resting versus exercising systemic metabolic conditions (low vs. high lactate and nonesterified fatty acids in the perfusate). Glycogen preservation, resulting from better maintenance of high-energy phosphates, was a consequence of improved energy homeostasis with high fat and lactate. We explained the result by tighter coupling between workload and total β-oxidation. Total fatty acid oxidation with high fat and lactate reflected increased availability of exogenous and endogenous fats for respiration, as evidenced by increased long-chain fatty acyl-CoA esters (LCFA-CoAs) and by an increased contribution of triglycerides to total β-oxidation. Triglyceride turnover (synthesis and degradation) also appeared to increase. Elevated LCFA-CoAs caused high total β-oxidation despite increased malonyl-CoA. The resulting bottleneck at mitochondrial uptake of LCFA-CoAs stimulated triglyceride synthesis. Our results suggest the following. First, both malonyl-CoA and LCFA-CoAs determine total fatty acid oxidation in heart. Second, concomitant stimulation of peripheral glycolysis and lipolysis should improve cardiac energy homeostasis during exercise. We speculate that high lactate contributes to the salutary effect by bypassing the glycolytic block imposed by fatty acids, acting as an anaplerotic substrate necessary for high tricarbocylic acid cycle flux from fatty acid-derived acetyl-CoA.

Evidence for ATP and ubiquitin dependent degradation of proteins in cultured bovine lens epithelial cells

1991 ◽  
Vol 52 (3) ◽  
pp. 341-347 ◽  
Author(s):  
Jessica Jahngen-Hodge ◽  
Eric Laxman ◽  
Antoinette Zuliani ◽  
Allen Taylor
Keyword(s):  
Epithelial Cells ◽  
Lens Epithelial Cells ◽  
Bovine Lens
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