The Role of Integrins in Human Embryo Implantation

2001 ◽  
Vol 16 (6) ◽  
pp. 364-371 ◽  
Author(s):  
Philippe Merviel ◽  
Jean-Claude Challier ◽  
Lionel Carbillon ◽  
Jean-Michel Foidart ◽  
Serge Uzan
Keyword(s):  
Human Embryo ◽  
Embryo Implantation

scholarly journals The role of microRNAs in human embryo implantation: a review

2018 ◽  
Vol 36 (2) ◽  
pp. 179-187 ◽  
Author(s):  
Anthea B. M. Paul ◽  
Seifeldin T. Sadek ◽  
Arnold M. Mahesan
Keyword(s):  
Human Embryo ◽  
Embryo Implantation

The role of apoptosis in human embryo implantation

2015 ◽  
Vol 108 ◽  
pp. 114-122 ◽  
Author(s):  
Sarah J. Boeddeker ◽  
Alexandra P. Hess
Keyword(s):  
Human Embryo ◽  
Embryo Implantation

scholarly journals Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 253
Author(s):  
Xi Guo ◽  
Hong Yi ◽  
Tin Chiu Li ◽  
Yu Wang ◽  
Huilin Wang ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Recurrent Miscarriage ◽  
Embryo Implantation ◽  
Critical Role ◽  
Angiogenic Factor ◽  
Vascular Endothelial ◽  
Underlying Mechanisms ◽  
Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.

scholarly journals COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation

2013 ◽  
Vol 27 (12) ◽  
pp. 2041-2054 ◽  
Author(s):  
Xilong Li ◽  
Michael J. Large ◽  
Chad J. Creighton ◽  
Rainer B. Lanz ◽  
Jae-Wook Jeong ◽  
...  
Keyword(s):  
Cell Fate ◽  
Cell Biology ◽  
Embryo Implantation ◽  
Orphan Nuclear Receptor ◽  
Loss Of Function ◽  
Mouse Uterus ◽  
Endometrial Stromal Cells ◽  
Endometrial Stroma ◽  
Stroma Cell

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism. Ablation of COUP-TFII in the mouse uterus causes infertility due to defects in embryo attachment and impaired uterine stromal cell decidualization. Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown. We observed that, as in mice, COUP-TFII is robustly expressed in the endometrial stroma of healthy women, and its expression is reduced in the ectopic lesions of women with endometriosis. To interrogate the role of COUP-TFII in human endometrial function, we used a small interfering RNA-mediated loss of function approach in primary human endometrial stromal cells. Attenuation of COUP-TFII expression did not completely block decidualization; rather it had a selective effect on gene expression. To better elucidate the role of COUP-TFII in endometrial stroma cell biology, the COUP-TFII transcriptome was defined by pairing microarray comparison with chromatin immunoprecipitation followed by deep sequencing. Gene ontology analysis demonstrates that COUP-TFII regulates a subset of genes in endometrial stroma cell decidualization such as those involved in cell adhesion, angiogenesis, and inflammation. Importantly this analysis shows that COUP-TFII plays a role in controlling the expression of inflammatory cytokines. The determination that COUP-TFII plays a role in inflammation may add insight into the role of COUP-TFII in embryo implantation and in endometrial diseases such as endometriosis.

scholarly journals Ephrin A1 induces intercellular dissociation in Ishikawa cells: possible implication of the Eph-ephrin A system in human embryo implantation

2010 ◽  
Vol 26 (2) ◽  
pp. 299-306 ◽  
Author(s):  
H. Fujii ◽  
H. Fujiwara ◽  
A. Horie ◽  
Y. Sato ◽  
I. Konishi
Keyword(s):  
Human Embryo ◽  
Embryo Implantation ◽  
Ishikawa Cells

The role of the leukemia inhibitory factor receptor in embryo implantation and placentation

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 139
Author(s):  
Jumpei Terakawa ◽  
Kazuhiro Matsuo ◽  
Takafumi Namiki ◽  
Kana Ohtomo ◽  
Atsuko Kageyama ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Embryo Implantation ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor

Endometrial Receptivity and Human Embryo Implantation

2011 ◽  
Vol 66 ◽  
pp. 23-30 ◽  
Author(s):  
Najwa A. Rashid ◽  
Sujata Lalitkumar ◽  
Parameswaran G. Lalitkumar ◽  
Kristina Gemzell-Danielsson
Keyword(s):  
Human Embryo ◽  
Embryo Implantation ◽  
Endometrial Receptivity
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