Effect of Excitatory Amino Acids on Serum TSH and Thyroid Hormone Levels in Freely Moving Rats

2000 ◽  
Vol 54 (2) ◽  
pp. 78-83 ◽  
Author(s):  
M. Alfonso ◽  
R. Durán ◽  
M.C. Arufe
Keyword(s):  
Amino Acids ◽  
Thyroid Hormone ◽  
Excitatory Amino Acids ◽  
Hormone Levels ◽  
Freely Moving Rats ◽  
Freely Moving ◽  
Thyroid Hormone Levels ◽  
Serum Tsh

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

10.3791/58455 ◽  
2018 ◽  
Author(s):  
Marie Soukupová ◽  
Chiara Falcicchia ◽  
Francesca Lovisari ◽  
Selene Ingusci ◽  
Mario Barbieri ◽  
...  
Keyword(s):  
Amino Acids ◽  
Excitatory Amino Acids ◽  
Freely Moving Rats ◽  
Freely Moving ◽  
Eeg Recordings

Changes in serum angiotensin-converting enzyme in acutely starved non-obese patients

1988 ◽  
Vol 118 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Gen Komaki ◽  
Hajime Tamai ◽  
Takahiro Mori ◽  
Tetsuya Nakagawa ◽  
Shu Mori
Keyword(s):  
Thyroid Hormone ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Level ◽  
Converting Enzyme ◽  
Normal Range ◽  
Serum Angiotensin Converting Enzyme ◽  
Hormone Levels ◽  
Acute Starvation ◽  
Thyroid Hormone Levels ◽  
Serum Tsh

Abstract. We investigated changes in the serum angiotensin-converting enzyme, as an index of thyroid hormone action, before, during and after fasting in 15 non-obese, hospitalized patients. Serum angiotensinconverting enzyme decreased significantly from 14.6 ± 1.1 U/l before fasting to 13.2 ± 1.1 U/l on the 5th day (P < 0.05, N = 15) during fasting, and to 10.6 ± 1.0 U/l on the 10th day (P < 0.05, N = 8). The serum TSH and T3 levels decreased significantly to below the normal range, and the serum T4 level decreased gradually during fasting, whereas free T4 (Amerlex) changed slightly, but within normal range. Although re-feeding did not lead to any reduction in the serum TSH, T3, or T4 level, the serum angiotensin-converting enzyme further decreased to 8.7 ± 0.9 U/l on the 5th day of re-feeding compared with that on the 10th day of fasting (P < 0.01, N = 8). There was a delay in the re-elevation of serum angiotensin-converting enzyme following a rise in serum T3. No correlations were found between serum angiotensin-converting enzyme levels and thyroid hormone levels throughout the study period. It is concluded that a significant reduction in the serum angiotensin-converting enzyme level occurs under a 'low T3' state during acute starvation, although there is no clear association between serum angiotensinconverting enzyme and thyroid hormone levels.

Suppressed Serum TSH with Normal Free Thyroid Hormone Levels in Patients with No History of Thyroid Disorder

1989 ◽  
Vol 76 (s20) ◽  
pp. 45P-45P
Author(s):  
DJ Stott ◽  
J Finlayson ◽  
AR McLellan ◽  
P Chu ◽  
WD Alexander
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Disorder ◽  
Hormone Levels ◽  
Free Thyroid Hormone ◽  
History Of ◽  
Thyroid Hormone Levels ◽  
Serum Tsh

LOW SERUM TSH WITH NORMAL TOTAL THYROID HORMONE LEVELS: AN INDICATOR OF FREE T4 EXCESS

1989 ◽  
Vol 30 (6) ◽  
pp. 627-634 ◽  
Author(s):  
B. P. O'MALLEY ◽  
F. D. ROSENTHAL ◽  
A. EXLEY ◽  
J. F. FALCONER-SMITH ◽  
J. MAHABIR ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Free T4 ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Serum Tsh ◽  
Low Serum

Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population

2007 ◽  
Vol 292 (3) ◽  
pp. E765-E770 ◽  
Author(s):  
Pia Skov Hansen ◽  
Thomas Heiberg Brix ◽  
Ivan Iachine ◽  
Thorkild I. A. Sørensen ◽  
Kirsten Ohm Kyvik ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Free Triiodothyronine ◽  
Environmental Correlations ◽  
Serum Free ◽  
Hormone Levels ◽  
Opposite Sex ◽  
Thyroid Hormone Levels ◽  
Serum Tsh ◽  
Danish Twin

Serum thyrotropin (TSH), free thyroxine (T4), and free triiodothyronine (T3) levels illustrate the thyroid function set point, but the interrelations between these have never been characterized in detail. The aim of this study was to examine the associations between TSH and thyroid hormone levels in healthy euthyroid twins and to determine the extent to which the same genes influence more than one of these biochemical traits; 1,380 healthy euthyroid Danish twins (284 monozygotic, 286 dizygotic, 120 opposite-sex twin pairs) were recruited. Genetic and environmental associations between thyroid function measurements were examined using quantitative genetic modeling. In bivariate genetic models, the phenotypic relation between two measurements was divided into genetic and environmental correlations. Free T4 and free T3 levels were positively correlated ( r = 0.32, P < 0.0001). The genetic correlation between serum free T4 and free T3 levels was rg = 0.25 (95% CI 0.14–0.35), suggesting that a set of common genes affect both phenotypes (pleiotropy). The correlation between the environmental effects was re = 0.41 (0.32–0.50). From this we calculated that the proportion of the correlation between free T4 and free T3 levels mediated by common genetic factors was 48%. Only 7% of the genetic component of serum free T3 levels is shared with serum free T4. Serum TSH and thyroid hormone levels did not share any genetic influences. In conclusion, thyroid hormone levels are partly genetically correlated genes that affect free T4 levels and exert pleiotropic effects on free T3 levels, although most of the genetic variance for these measurements is trait specific.

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