Suppressed Serum TSH with Normal Free Thyroid Hormone Levels in Patients with No History of Thyroid Disorder

1989 ◽  
Vol 76 (s20) ◽  
pp. 45P-45P
Author(s):  
DJ Stott ◽  
J Finlayson ◽  
AR McLellan ◽  
P Chu ◽  
WD Alexander
2013 ◽  
Vol 5 (01) ◽  
pp. 26-29 ◽  
Author(s):  
Abiodun Mathias Emokpae ◽  
Aliyu Abdu ◽  
Humphrey Benedo Osadolor

ABSTRACT Background: High blood pressure (BP) is a major health problem in Nigeria and the involvement of thyroid hormones in this condition has not been evaluated in this center. Objective: The objective of this study was to evaluate the proportion of patients with an essential hypertension who had abnormal thyroid hormone levels and the type of thyroid disorders commonly observed in this group of patients. Materials and Methods: A retrospective study of 94 patients (30 males, aged 30.4 ± 2 years and 64 females, aged 43.4 ± 1.3 years) with essential hypertension was carried out between January 2005 and December 2007. Demographic and other medical information were obtained from the health records. Analysis of laboratory results of triiodothyronine (T3), Thyroxine (T4), and thyroid stimulating hormone (TSH) were made. Results: Of the 94 patients evaluated, 26 (27.7%) had abnormal thyroid hormone levels, with 23.4% having hyperthyroidism, 4.3% had sub-clinical hypothyroidism and none had overt hypothyroidism. Of the 26 subjects with abnormal thyroid hormone levels, 18 (69.2%) were females while 8 (30.8%) were males. Out of the 18 female subjects with abnormal thyroid hormone levels, 16 had hyperthyroid levels while 2 had sub-clinical hypothyroid levels. Out of the 8 male patients, 6 had hyperthyroid hormone levels while 2 had sub-clinical hypothyroid levels. Conclusion: Thyroid hormone abnormalities are common in patients with essential hypertension. Hyperthyroidism was the most common thyroid disorder observed. Young patients presenting with essential hypertension should be screened for thyroid hormone abnormalities since they can best be managed by treating the underlying causes.


Author(s):  
J H Parr

Serum concentration of free T3 and, in female patients, FT4, were found to be lower in 20 asymptomatic, moderately-poor or well controlled, diabetics treated with insulin than in a group of non-diabetic subjects. Over a mean 3-month period of the study a significant fall occurred in HbA1 concentration in both groups of diabetics without change in free thyroid hormone levels. The mean capillary blood glucose, fasting free insulin and fasting lipid concentrations, other than high density lipoprotein (HDL) cholesterol, did not change. No correlations were found between the changes in HbA1 and free thyroid hormone concentrations. Improvement in long term metabolic control did not influence free thyroid hormone levels in well controlled and moderately-poor controlled diabetics, taking insulin.


1967 ◽  
Vol 27 (8) ◽  
pp. 1219-1223 ◽  
Author(s):  
CHARLES S. HOLLANDER ◽  
ROBERT L. SCOTT ◽  
JOHN A. BURGESS ◽  
DAVID RABINOWITZ ◽  
THOMAS J. MERIMEE ◽  
...  

Nephron ◽  
1989 ◽  
Vol 52 (4) ◽  
pp. 360-362 ◽  
Author(s):  
Michael J. Hardy ◽  
Luiz Nascimento ◽  
Sati Ragbeer ◽  
Samia Bukhari ◽  
Abdulhamid Kashgari

1988 ◽  
Vol 118 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Gen Komaki ◽  
Hajime Tamai ◽  
Takahiro Mori ◽  
Tetsuya Nakagawa ◽  
Shu Mori

Abstract. We investigated changes in the serum angiotensin-converting enzyme, as an index of thyroid hormone action, before, during and after fasting in 15 non-obese, hospitalized patients. Serum angiotensinconverting enzyme decreased significantly from 14.6 ± 1.1 U/l before fasting to 13.2 ± 1.1 U/l on the 5th day (P < 0.05, N = 15) during fasting, and to 10.6 ± 1.0 U/l on the 10th day (P < 0.05, N = 8). The serum TSH and T3 levels decreased significantly to below the normal range, and the serum T4 level decreased gradually during fasting, whereas free T4 (Amerlex) changed slightly, but within normal range. Although re-feeding did not lead to any reduction in the serum TSH, T3, or T4 level, the serum angiotensin-converting enzyme further decreased to 8.7 ± 0.9 U/l on the 5th day of re-feeding compared with that on the 10th day of fasting (P < 0.01, N = 8). There was a delay in the re-elevation of serum angiotensin-converting enzyme following a rise in serum T3. No correlations were found between serum angiotensin-converting enzyme levels and thyroid hormone levels throughout the study period. It is concluded that a significant reduction in the serum angiotensin-converting enzyme level occurs under a 'low T3' state during acute starvation, although there is no clear association between serum angiotensinconverting enzyme and thyroid hormone levels.


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