Effect of Topical Betaxolol on the Acute Rise of Aqueous Flare Induced by Highly Selective Agonists for Prostaglandin E2 Receptor Subtypes in Pigmented Rabbits

2002 ◽  
Vol 34 (1) ◽  
pp. 48-50 ◽  
Author(s):  
Shuichiro Yanagisawa ◽  
Seiji Hayasaka ◽  
Xue-Yun Zhang ◽  
Yoriko Hayasaka ◽  
Yasunori Nagaki ◽  
...  
Keyword(s):  
Prostaglandin E ◽  
Receptor Subtypes ◽  
Aqueous Flare ◽  
Selective Agonists ◽  
Pigmented Rabbits

Novel four selective agonists for prostaglandin E receptor subtypes

1999 ◽  
Vol 59 (1-6) ◽  
pp. 150 ◽  
Author(s):  
Hiroshi Yamamoto ◽  
Takayuki Maruyama ◽  
Kiyoto Sakata ◽  
Masatoshi Koketsu ◽  
Michiyoshi Kobayashi ◽  
...  
Keyword(s):  
Prostaglandin E ◽  
Receptor Subtypes ◽  
Selective Agonists

Effects of Topical Mydriatics and Vasoconstrictors on Prostaglandin-E2-Induced Aqueous Flare Elevation in Pigmented Rabbits

2003 ◽  
Vol 35 (5) ◽  
pp. 256-260 ◽  
Author(s):  
Yoriko Hayasaka ◽  
Seiji Hayasaka ◽  
Xue-Yun Zhang ◽  
Yasunori Nagaki
Keyword(s):  
Prostaglandin E ◽  
Aqueous Flare ◽  
Pigmented Rabbits

Effects of Oral Administration of Gardeniae fructus Extract and Intravenous Injection of Crocetin on Lipopolysaccharide- and Prostaglandin E2-induced Elevation of Aqueous Flare in Pigmented Rabbits

2003 ◽  
Vol 31 (05) ◽  
pp. 729-738 ◽  
Author(s):  
Yasunori Nagaki ◽  
Seiji Hayasaka ◽  
Tomohiro Abe ◽  
Xue-Yun Zhang ◽  
Yoriko Hayasaka ◽  
...  
Keyword(s):  
Oral Administration ◽  
Intravenous Injection ◽  
Area Under The Curve ◽  
Prostaglandin E ◽  
Dependent Manner ◽  
Aqueous Flare ◽  
Laser Flare ◽  
Coptidis Rhizoma ◽  
Phellodendri Cortex ◽  
Pigmented Rabbits

The purpose of this study was to evaluate the effects of extracts of Coptidis rhizoma, Phellodendri cortex and Gardeniae fructus, which are medicinal herbs in Orengedoku-to (Huanglin-Jie-Du-Tang in Chinese), and crocetin (a major component of Gardeniae fructus) on experimental elevation of aqueous flare in pigmented rabbits. To produce aqueous flare elevation, 0.5 μg/kg lipopolysaccharide (LPS) was injected into the ear vein, or prostaglandin E2 (PGE2) 25 μg/ml, was applied to the cornea by means of a glass cylinder. Animals were pretreated by oral administration of 150 g/day of food containing 0.15% (w/w) extract powder of Coptidis rhizoma, 0.10% (w/w) extract powder of Phellodendri cortex or 0.15% (w/w) extract powder of Gardeniae fructus for 4 days, or by intravenous injection of crocetin, 0.3, 3, 30 or 300 μg/kg, 30 minutes before aqueous flare elevation. Aqueous flare was measured with a laser flare-cell meter. Aqueous flare intensity was expressed as the area under the curve (AUC) in arbitrary units. The AUC of LPS- and PGE2-induced aqueous flare elevation was 4685 and 1386 arbitrary units, respectively. Pretreatment by oral administration of 0.15% (w/w) extract of Coptidis rhizoma or 0.10% (w/w) extract of Phellodendri cortex did not inhibit LPS-induced aqueous flare elevation. Pretreatment by oral administration of 0.15% extract of Gardeniae fructus suppressed LPS-induced aqueous flare elevation (AUC: 1411 arbitrary units). Pretreatment by intravenous injection of 3, 30 or 300 μg/kg of crocetin-inhibited LPS-induced aqueous flare elevation in a dose-dependent manner. Pretreatment with 3 or 30 μg/kg of crocetin did not inhibit PGE2-induced aqueous flare elevation, but 300 μg/kg of crocetin inhibited PGE2-induced aqueous flare elevation (AUC: 918 arbitrary units).

Effect of Topical Iganidipine on Experimental Elevation of Aqueous Flare Induced by Prostaglandin E2 and EP Agonists in Pigmented Rabbits

2002 ◽  
Vol 34 (4) ◽  
pp. 195-199 ◽  
Author(s):  
Shuichiro Yanagisawa ◽  
Seiji Hayasaka ◽  
Xue-Yun Zhang ◽  
Yoriko Hayasaka ◽  
Yasunori Nagaki
Keyword(s):  
Prostaglandin E ◽  
Aqueous Flare ◽  
Pigmented Rabbits

Effects of Isopropyl Unoprostone, Latanoprost, and Prostaglandin E2 on Acute Rise of Aqueous Flare in Pigmented Rabbits

2002 ◽  
Vol 34 (2) ◽  
pp. 90-93 ◽  
Author(s):  
Xue-Yun Zhang ◽  
Seiji Hayasaka ◽  
Yoriko Hayasaka ◽  
Shuichiro Yanagisawa ◽  
Yasunori Nagaki
Keyword(s):  
Prostaglandin E ◽  
Aqueous Flare ◽  
Pigmented Rabbits

Effects of Topical Clonidine on Prostaglandin-E2-Induced Aqueous Flare Elevation in Pigmented Rabbits

2000 ◽  
Vol 32 (5) ◽  
pp. 210-214
Author(s):  
Kazuhiko Watanabe ◽  
Seiji Hayasaka ◽  
Shigeyoshi Hiraki ◽  
Masayuki Matsumoto ◽  
Chiharu Kadoi ◽  
...  
Keyword(s):  
Prostaglandin E ◽  
Aqueous Flare ◽  
Pigmented Rabbits ◽  
Topical Clonidine
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