Lipoic Acid Prevents Suppression of Connective Tissue Proliferation in the Rat Liver Induced by n–3 PUFAs

2000 ◽  
Vol 44 (5-6) ◽  
pp. 217-222 ◽  
Author(s):  
Andres Arend ◽  
Mihkel Zilmer ◽  
Tiiu Vihalemm ◽  
Gunnar Selstam ◽  
Ennu Sepp
Keyword(s):  
Connective Tissue ◽  
Rat Liver ◽  
Lipoic Acid ◽  
Tissue Proliferation

scholarly journals Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Anna Bilska-Wilkosz ◽  
Magdalena Kotańska ◽  
Magdalena Górny ◽  
Barbara Filipek ◽  
Małgorzata Iciek
Keyword(s):  
Blood Pressure ◽  
Rat Liver ◽  
Lipoic Acid ◽  
Aldh Activity ◽  
Dihydrolipoic Acid ◽  
Treatment Groups ◽  
Intracellular Compartments ◽  
Electrocardiogram Ecg ◽  
First Time ◽  
All Treatment

The exogenous lipoic acid (LA) is successfully used as a drug in the treatment of many diseases. It is assumed that after administration, LA is transported to the intracellular compartments and reduced to dihydrolipoic acid (DHLA) which is catalyzed by NAD(P)H-dependent enzymes. The purpose of this study was to investigate whether LA can attenuate cardiovascular disturbances induced by ethanol (EtOH) and disulfiram (DSF) administration separately or jointly in rats. For this purpose, we measured systolic and diastolic blood pressure, recorded electrocardiogram (ECG), and estimated mortality of rats. We also studied the activity of aldehyde dehydrogenase (ALDH) in the rat liver. It was shown for the first time that LA partially attenuated the cardiac arrhythmia (extrasystoles and atrioventricular blocks) induced by EtOH and reduced the EtOH-induced mortality of animals, which suggests that LA may have a potential for use in cardiac disturbance in conditions of acute EtOH intoxication. The administration of EtOH, LA, and DSF separately or jointly affected the ALDH activity in the rat liver since a significant decrease in the activity of the enzyme was observed in all treatment groups. The results indicating that LA is an inhibitor of ALDH activity are very surprising.

Fibroblasts and Phagocytic Cells in Phenytoin-induced Connective Tissue Proliferation

2012 ◽  
Vol 2 ◽  
pp. 113-120
Author(s):  
Rosaiah Kanaparthy ◽  
Aruna Kanaparthy ◽  
Kamala Devi
Keyword(s):  
Connective Tissue ◽  
Phagocytic Cells ◽  
Tissue Proliferation

Inhibition of glucose production and stimulation of bile flow by R (+)-α-lipoic acid enantiomer in rat liver

2002 ◽  
Vol 22 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Christian Anderwald ◽  
Georg Koca ◽  
Clemens Fürnsinn ◽  
Werner Waldhäusl ◽  
Michael Roden
Keyword(s):  
Rat Liver ◽  
Lipoic Acid ◽  
Bile Flow ◽  
Glucose Production ◽  
Stimulation Of

Myxobolid parasites (Myxozoa: Myxobolidae) infecting fishes of western Montana, with notes on histopathology, seasonality, and intraspecific variation

1989 ◽  
Vol 67 (8) ◽  
pp. 1915-1922 ◽  
Author(s):  
Lawrence G. Mitchell
Keyword(s):  
Connective Tissue ◽  
Western Montana ◽  
Infection Prevalence ◽  
Tissue Proliferation ◽  
Prosopium Williamsoni ◽  
Catostomus Macrocheilus ◽  
Redside Shiner ◽  
Richardsonius Balteatus ◽  
Cyst Rupture ◽  
Longnose Sucker

Cypriniform and salmonid fishes of the Columbia River drainage of western Montana harbor five members of the myxozoan family Myxobolidae. Myxobolus muelleri inhabits Ptychocheilus oregonensis (northern squawfish), Mylocheilus caurinus (peamouth), Richardsonius balteatus (redside shiner), and Catostomus macrocheilus (largescale sucker). Cysts appeared in gills, musculature, subcutis, and visceral mesenteries. Unencysted spores infiltrated mesenteries and viscera. Spore size and shape in the various tissues and hosts were highly varied. Muscle and subcutaneous cysts were associated with connective tissue proliferation and muscle degeneration; cyst rupture was associated with diffuse inflammation and rodlet cell proliferation. Infection prevalence in muscles and kidneys was high in adult and juvenile hosts (78–100%) throughout the year. Seasonal prevalence of gill and subcutaneous infections fluctuated markedly. Cysts of Myxobolus dujardini occurred in gills of the northern squawfish, peamouth, and redside shiner. Unicauda sp. was found in the eye capsule, gall bladder, mesenteries, and kidney of northern squawfish. Henneguya zschokkei occurred in intermuscular connective tissue of Prosopium coulteri (pygmy whitefish) and Prosopium williamsoni (mountain whitefish). Myxobolus sp. occurred in the gills of Catostomus catostomus (longnose sucker).

scholarly journals Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver

2015 ◽  
Vol 69 ◽  
pp. 270-276 ◽  
Author(s):  
Anna Goraca ◽  
Halina Huk-Kolega ◽  
Agata Kowalczyk ◽  
Beata Skibska
Keyword(s):  
Rat Liver ◽  
Lipoic Acid ◽  
Anti Inflammatory

scholarly journals Histological analysis of state of tissues in internal organs of black-backed shad Alosa kessleri kessleri

2017 ◽  
Vol 188 (1) ◽  
pp. 155-161
Author(s):  
Maria P. Grushko ◽  
Nadezhda N. Fedorova ◽  
Alina A. Aitimova
Keyword(s):  
Connective Tissue ◽  
Environmental Pollution ◽  
Histological Analysis ◽  
Internal Organs ◽  
Common Features ◽  
Tissue Proliferation ◽  
Wide Range ◽  
Negative Impacts

Internal organs of black-backed shad are examined by histological analysis. Wide range of pathologies is found, which are supposedly caused by chronic environmental pollution. The pathologies of tissue and cellular levels have common features but various symptoms, as edema, hemorrhage, necrosis, inflammation, connective tissue proliferation, proliferative changes in the epithelium. The gills, liver; kidney, and intestines are the most sensitive to negative impacts of environments.

α-Lipoic acid promotes preneoplastic growth in rat liver

2007 ◽  
Vol 45 (01) ◽  
Author(s):  
A Perra ◽  
M Pibiri ◽  
P Sulas ◽  
GM Ledda-Columbano ◽  
A Columbano
Keyword(s):  
Rat Liver ◽  
Lipoic Acid
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