Epoetin Alfa in Low Hematocrit Patients to Facilitate Autologous Blood Donation in Total Hip Replacement: A Randomized, Double-Blind, Placebo- Controlled, Dose-Ranging Study

1998 ◽  
Vol 100 (2) ◽  
pp. 69-76 ◽  
Author(s):  
F. Mercuriali ◽  
G. Inghilleri ◽  
E. Biffi ◽  
M.T. Colotti ◽  
A. Vinci ◽  
...  
Keyword(s):  
Total Hip Replacement ◽  
Hip Replacement ◽  
Blood Donation ◽  
Autologous Blood ◽  
Autologous Blood Donation ◽  
Epoetin Alfa ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Hip ◽  
Dose Ranging

AUTOLOGOUS BLOOD DONATION IN TOTAL HIP REPLACEMENT

1995 ◽  
Vol 65 (6) ◽  
pp. 449-449
Author(s):  
P. D. Hughes ◽  
M. J. Gillespie ◽  
K. E. Downes ◽  
M. Done ◽  
J. Major ◽  
...  
Keyword(s):  
Total Hip Replacement ◽  
Hip Replacement ◽  
Blood Donation ◽  
Autologous Blood ◽  
Autologous Blood Donation ◽  
Total Hip

scholarly journals Nonanemic Patients Do Not Benefit from Autologous Blood Donation Before Total Hip Replacement

2009 ◽  
Vol 6 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Friedrich Boettner ◽  
Eric I. Altneu ◽  
Brendan A. Williams ◽  
Matthew Hepinstall ◽  
Thomas P. Sculco
Keyword(s):  
Total Hip Replacement ◽  
Hip Replacement ◽  
Blood Donation ◽  
Autologous Blood ◽  
Autologous Blood Donation ◽  
Total Hip

Effects on Coagulation and Fibrinolysis of Desmopressin in Patients Undergoing Total Hip Replacement

1991 ◽  
Vol 66 (06) ◽  
pp. 652-656 ◽  
Author(s):  
Per Anders Flordal ◽  
Karl-Gösta Ljungström ◽  
Jan Svensson ◽  
Brenda Ekman ◽  
Gustaf Neander
Keyword(s):  
Total Hip Replacement ◽  
Hip Replacement ◽  
Bleeding Time ◽  
Antithrombin Iii ◽  
Postoperative Bleeding ◽  
Double Blind ◽  
Total Hip ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Coagulation And Fibrinolysis

SummaryTwelve patients undergoing total hip replacement, with regional anaesthesia and with dextran infusion for plasma expansion and thromboprophylaxis, were given the vasopressin analogue desmopressin (DDAVP) or placebo in a randomized, double-blind prospective study. In controls (n = 6) we found a prolongation of the bleeding time, low factor VIII (FVIII) and von Willebrand factor (vWF) and a decrease in antithrombin III to levels known to be at risk for venous thrombosis. Desmopressin shortened postoperative bleeding time, gave an early FVIII/vWF complex increase, prevented antithrombin III from falling to critically low values and appeared to activate the fibrinolytic system, both by tPA increase and PAI-1 decrease.Thus in the controls we found changes in both coagulation and fibrinolysis indicating a haemorrhagic diathesis as well as a risk for thromboembolism. Desmopressin induced factor changes that possibly reduce both risks.

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