Mutation and Methylation Status of p53 Gene Promoter in Human Breast Tumours

Tumor Biology ◽  
1999 ◽  
Vol 20 (6) ◽  
pp. 341-346 ◽  
Author(s):  
B.K. Nayak ◽  
B.R. Das
Keyword(s):  
Methylation Status ◽  
Gene Promoter ◽  
P53 Gene ◽  
Human Breast ◽  
Breast Tumours

Rearrangement of the P53 Gene in Human Breast Tumours

1998 ◽  
Vol 245 (2) ◽  
pp. 388-391 ◽  
Author(s):  
B.K. Nayak ◽  
S. Patnaik ◽  
B.R. Das
Keyword(s):  
P53 Gene ◽  
Human Breast ◽  
Breast Tumours

scholarly journals Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zijian Chen ◽  
Zenghong Huang ◽  
Yanxin Luo ◽  
Qi Zou ◽  
Liangliang Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Promoter Methylation ◽  
Expression Profiles ◽  
Methylation Status ◽  
Gene Promoter ◽  
Normal Mucosa ◽  
Suppressor Gene ◽  
Survival Outcome ◽  
Prognostic Models

Abstract Background Neurotrophic tropomyosin receptor kinases (NTRKs) are a gene family function as oncogene or tumor suppressor gene in distinct cancers. We aimed to investigate the methylation and expression profiles and prognostic value of NTRKs gene in colorectal cancer (CRC). Methods An analysis of DNA methylation and expression profiles in CRC patients was performed to explore the critical methylations within NTRKs genes. The methylation marker was validated in a retrospectively collected cohort of 229 CRC patients and tested in other tumor types from TCGA. DNA methylation status was determined by quantitative methylation-specific PCR (QMSP). Results The profiles in six CRC cohorts showed that NTRKs gene promoter was more frequently methylated in CRC compared to normal mucosa, which was associated with suppressed gene expression. We identified a specific methylated region within NTRK3 promoter targeted by cg27034819 and cg11525479 that best predicted survival outcome in CRC. NTRK3 promoter methylation showed independently predictive value for survival outcome in the validation cohort (P = 0.004, HR 2.688, 95% CI [1.355, 5.333]). Based on this, a nomogram predicting survival outcome was developed with a C-index of 0.705. Furthermore, the addition of NTRK3 promoter methylation improved the performance of currently-used prognostic model (AIC: 516.49 vs 513.91; LR: 39.06 vs 43.64, P = 0.032). Finally, NTRK3 promoter methylation also predicted survival in other tumors, including pancreatic cancer, glioblastoma and stomach adenocarcinoma. Conclusions This study highlights the essential value of NTRK3 methylation in prognostic evaluation and the potential to improve current prognostic models in CRC and other tumors.

The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

2001 ◽  
Vol 70 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Mumtaz Iscan ◽  
Tuula Klaavuniemi ◽  
Tulay Çoban ◽  
Nilgun Kapucuoğlu ◽  
Olavi Pelkonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Human Breast ◽  
Cytochrome P450 Enzymes ◽  
Breast Tumours

A cross-linking assay allows the detection of receptors for the somatostatin analogue, lanreotide in human breast tumours

1993 ◽  
Vol 29 (11) ◽  
pp. 1589-1592 ◽  
Author(s):  
Grégoire Prévost ◽  
Philippe Provost ◽  
Valérie Sallé ◽  
Monique Lanson ◽  
François Thomas
Keyword(s):  
Cross Linking ◽  
Somatostatin Analogue ◽  
Human Breast ◽  
Breast Tumours

scholarly journals Rapid assay for thein vitro chemosensitivity testing of human breast tumours

1989 ◽  
Vol 11 (6) ◽  
pp. 244-244
Author(s):  
R. F. M. Oude Elferink ◽  
H. M. J. Goldschmidt ◽  
H. J. Majoor ◽  
J. F. Leijten
Keyword(s):  
Human Breast ◽  
Breast Tumours ◽  
Chemosensitivity Testing ◽  
Rapid Assay

Significance of Ca antigen expression in human breast tumours

1985 ◽  
Vol 13 (2) ◽  
pp. 458-458
Author(s):  
DAKSHA P. TRIVEDI ◽  
HAROLD BAUM ◽  
MICHAEL BAUM
Keyword(s):  
Antigen Expression ◽  
Human Breast ◽  
Breast Tumours

scholarly journals Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
Eleanor Broadberry ◽  
James McConnell ◽  
Jack Williams ◽  
Nan Yang ◽  
Egor Zindy ◽  
...  
Keyword(s):  
Tissue Mechanics ◽  
Circadian Clocks ◽  
Human Breast ◽  
Breast Tumours ◽  
Primary Human Breast
Sign in / Sign up

Export Citation Format

Share Document